CoChat
Sign Up
Cited by 97Intracerebral and Subarachnoid Hemorrhage ResearchDementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

High Prevalence of Cerebral Microbleeds at 7Tesla MRI in Patients with Early Alzheimer's Disease

Brundel, Manon, Heringa, Sophie M., de Bresser, Jeroen, Koek, Huiberdina L., Zwanenburg, Jaco J.M., Kappelle, L. Jaap, Luijten, Peter R., Biessels, Geert Jan·2012·Journal of Alzheimer's Disease
DOI 10.3233/jad-2012-120364
Open this paper in CoChat — free account

Abstract

The prevalence of microbleeds on magnetic resonance imaging (MRI) in patients with Alzheimer's disease (AD) is lower than that of its presumed pathological correlate, cerebral amyloid angiopathy. We examined 18 patients with early AD or mild cognitive impairment (MCI) and 18 non-demented controls with ultra-high field strength 7Tesla MRI, to assess if the actual prevalence of microbleeds could be higher than is currently reported. One or more microbleeds were visualized in 78% of the MCI/AD patients and in 44% of the controls (p = 0.04). 7Tesla MRI shows that presence of microbleeds may be the rule, rather than exception in patients with MCI/AD.

Integrity signals

Registry

Crossref · 10.3233/jad-2012-120364

Cites

3 of 3 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • The broad range of detection of microbleeds could likely be attributed to the magnet field strength, with clinical strength 1.5 and 3T magnets likely underestimating the incidence of microbleeds compared with the research-grade 7T magnet.

    “This broad range of detection could likely be attributed to the magnet field strength, with clinical strength 1.5 and 3T magnets likely underestimating the incidence of microbleeds compared with the research-grade 7T magnet (83, 246, 452, 530, 604, 669).”

    From Blood-Brain Barrier: From Physiology to Disease and Back (2019) · cites this paper as [83]

  • CNS microbleeds reflect loss of cerebrovascular integrity and are found in 25% of individuals with MCI and 45-78% of individuals with early AD without dementia.

    “CNS microbleeds reflect loss of cerebrovascular integrity and are found in 25% of individuals with MCI (669) and 45-78% of individuals with early AD without dementia (83, 208, 246, 452, 476, 529, 604, 702).”

    From Blood-Brain Barrier: From Physiology to Disease and Back (2019) · cites this paper as [83]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Brundel, M., Heringa, S. M., de Bresser, J., Koek, H. L., Zwanenburg, J. J. M., Kappelle, L. J., Luijten, P. R., & Biessels, G. J.
Affiliations
  • University Medical Center Utrecht (NL)
  • Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, the Netherlands
Corresponding author
Brundel, Manon
ORCID
Venue
Journal of Alzheimer's Disease
Publisher
SAGE Publications
Published
2012-07-31
Volume
31
Issue
2
Pages
259-263
ISSN
  • 1387-2877 (ISSN-L)
  • 1875-8908
DOI
10.3233/jad-2012-120364
OpenAlex
W1599725265
Cited by
97
References
3
Citations by year
2025: 9 · 2024: 5 · 2023: 7 · 2022: 8 · 2021: 8 · 2020: 10 · 2019: 3 · 2018: 9 · 2017: 5 · 2016: 4 · 2015: 13 · 2014: 10 · 2013: 4 · 2012: 2
FWCI
6.05
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Alzheimer s Disease (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Neurology › Intracerebral and Subarachnoid Hemorrhage Research
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Keywords
cerebral microbleeds, Alzheimer's disease
MeSH terms
Aged, Aged, 80 and over, Alzheimer Disease, Cerebral Hemorrhage, Female, Humans, Male, Microcirculation, Prevalence, Echo-Planar Imaging, Early Diagnosis

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review