Cited by 75Barrier Structure and Function StudiesCerebrospinal fluid and hydrocephalusNeuroinflammation and Neurodegeneration Mechanisms

Basal lamina changes in neurodegenerative disorders

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Nguyen, Benjamin, Bix, Gregory, Yao, Yao·2021·Molecular Neurodegeneration

Abstract

Background: Neurodegenerative disorders are a group of age-associated diseases characterized by progressive degeneration of the structure and function of the CNS. Two key pathological features of these disorders are blood-brain barrier (BBB) breakdown and protein aggregation. Main body: The BBB is composed of various cell types and a non-cellular component---the basal lamina (BL). Although how different cells affect the BBB is well studied, the roles of the BL in BBB maintenance and function remain largely unknown. In addition, located in the perivascular space, the BL is also speculated to regulate protein clearance via the meningeal lymphatic/glymphatic system. Recent studies from our laboratory and others have shown that the BL actively regulates BBB integrity and meningeal lymphatic/glymphatic function in both physiological and pathological conditions, suggesting that it may play an important role in the pathogenesis and/or progression of neurodegenerative disorders. In this review, we focus on changes of the BL and its major components during aging and in neurodegenerative disorders, including Alzheimer’s disease (AD), Parkinson’s disease (PD), and amyotrophic lateral sclerosis (ALS). First, we introduce the vascular and lymphatic systems in the CNS. Next, we discuss the BL and its major components under homeostatic conditions, and summarize their changes during aging and in AD, PD, and ALS in both rodents and humans. The functional significance of these alterations and potential therapeutic targets are also reviewed. Finally, key challenges in the field and future directions are discussed. Conclusions: Understanding BL changes and the functional significance of these changes in neurodegenerative disorders will fill the gap of knowledge in the field. Our goal is to provide a clear and concise review of the complex relationship between the BL and neurodegenerative disorders to stimulate new hypotheses and further research in this field.

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Authors
Nguyen, B., Bix, G., & Yao, Y.
Affiliations
  • University of Georgia (US)
  • Tulane University (US)
Corresponding author
Yao, Yao
Venue
Molecular Neurodegeneration
Published
2021-12-07
Volume
16
Issue
1
Pages
81-81
ISSN
1750-1326 (ISSN-L)
OpenAlex
W4200551731
Cited by
75
References
354
Citations by year
2026: 9 · 2025: 23 · 2024: 16 · 2023: 13 · 2022: 14
FWCI
1.27
Type
journal article
Language
en
Open access
Locations
  • Molecular Neurodegeneration (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • National Heart, Lung, and Blood Institute (R01HL146574)
  • National Institute on Aging (R21AG064422, R21AG073862, RF1AG065345)
  • American Heart Association (16SDG29320001)
Topics
  • Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Cerebrospinal fluid and hydrocephalus
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
basement membrane, neurodegenerative diseases, blood-brain barrier, Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, aging, meningeal lymphatic system, glymphatic system, protein clearance, protein aggregation, perivascular spaces, therapeutic target
MeSH terms
Glymphatic System, Alzheimer Disease, Basement Membrane, Blood-Brain Barrier, Humans, Neurodegenerative Diseases

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