Alzheimer’s Disease: Key Insights from Two Decades of Clinical Trial Failures

Kim, C. Kwon, Lee, Yin Rui, Ong, Lynnett, Gold, Michael, Kalali, Amir, Sarkar, Joydeep·2022·Journal of Alzheimer s Disease

DOI 10.3233/jad-215699

Cited by (243)

Items 201–243 of 243

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Targeting Intrinsic Neuronal Defense Against Multiple Insults: The “One4More” Therapeutic Strategy for Alzheimer’s Disease
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Ambre Leleu · 2024 · theses.fr (ABES)
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Christian Behl · 2026 · Springer eBooks
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Rachid Abbas · 2024 · theses.fr (ABES)
Zweifel an der Amyloid-Kaskaden-Hypothese, Neubewertungen und Verfeinerungen
Christian Behl · 2026 · Springer eBooks
Electrochemical Detection of Neuronal Injury in Cell Culture Samples: A Cost-Effective Biosensor for Neurofilament Light Sensing
Anna Panteleeva, Sujey Palma-Florez, Ashlyne M. Smith, Sara Palma-Tortosa, Zaal Kokaia, Josep Samitier, Mònica Mir · 2026 · Biosensors
Recent Advances in Drug Development for the Management of Alzheimer’s Disease
Amit Upadhyay, Abhishek Kumar Singh, Nandani Jayaswal, Pooja Jaiswal, S. N. Singh, Shashank Tewari · 2026 · BENTHAM SCIENCE PUBLISHERS eBooks
Predicting future cognitive impairment in preclinical Alzheimer’s disease using amyloid PET and MRI: A multisite machine learning study
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Allosteric Activation of GDH/TCA Pathway Reduces Pathological Build-Up and Promotes Neuronal Survival in an In Vitro Model of Alzheimer’s Disease
Tiziano Serfilippi, Silvia Piccirillo, Alessandra Preziuso, Valentina Terenzi, Raffaella Ciancio, Simona Magi, Vincenzo Lariccia, Agnese Secondo · 2026 · Biomolecules
Early proteomic signatures of Alzheimer’s disease in the retina and brain of 3xTg-AD mice
Artjola Puja, Rachel McNeel, Rong Xu, Siyan Zhu, David Hansman, Jianhai Du · 2026 · Frontiers in Cell and Developmental Biology
Bibliometric analysis of nanomaterials in the diagnosis and treatment of neurological and psychiatric disorders (1997–2025): trends and future directions
Min Hua Luo, Fukun Zhao, Yuan-min Wang, Jiang Bian, Yong Luo · 2026 · Journal of Nanobiotechnology
Predicting future dementia from routine clinical MRI and linked healthcare data
Parminder Singh Reel, Salim Al‐Wasity, Craig Edwards, Smarti Reel, Esma Mansouri-Benssassi, Szabolcs Suveges, Muthu Rama Krishnan Mookiah, Susan Krueger, Emanuele Trucco, Emily Jefferson et al. · 2026 · Alzheimer s Research & Therapy
Chitosan-based nanocarriers in Alzheimer’s disease therapy: recent developments and future perspectives
Dinesh Kumar Sharma, Chandra Shekhar Prasad · 2026 · Journal of drug targeting
Therapeutic targeting of DNA repair pathway dysregulation in aging, cancer, and neurodegeneration
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Molecular mechanisms underlying amyloid lowering by aducanumab: differential and comparative effects of sex and IgG reveal the post-treatment disease brain
Kathryn A. Haynes, Ravi S. Pandey, Emma H. Doud, Zackary A. Cope, Gabriela J. Little, Sean-Paul Williams, Umesh Nepali, Sara K. Quinney, Ankit Nagar, Nitin Charbe et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
Trends in the Engineering of Adeno-Associated Virus (AAV) for Precision Gene Delivery to the Central Nervous System (CNS)
Ezekiel S. Oloruntimehin, Alexander S. Malogolovkin · 2026 · International Journal of Molecular Sciences
Memory Protectors: Leveraging Artificial Intelligence for Early Detection, Progression Prediction, and Personalized Care in Alzheimer's Disease Management
Revatthy Krishnamurthy, Mohd. Farman Ali, Sunena Rose MV, Ravi A.T, R Sujitha, Kanchan Israni · 2026 · International Conference on AI, Data Science, Cyber Security and Smart Manufacturing for Sustainable Development (ICADCS)
Genetic Associations with Temporal Modeling of Alzheimer’s Disease Progression Supports a Novel Paradigm for Disease Risk
Daniel M. Jordan, Eli Kritzer, Ryan C. Thompson, Anina N. Lund, Tulsi Patel, Ariela Buxbaum Grice, D John, Alzheimer’s Disease Neuroimaging Initiative, Alzheimer’s Disease Neuroimaging Initiative, Alison Goate et al. · 2026 · medRxiv
Microglial synaptic pruning in early Alzheimer’s disease: emerging roles of the IL-1β-NLRP3 axis
Arjun Singh Kaushik, Nitin Singh · 2026 · Inflammopharmacology
The Role of Primary Care Physicians in Early Diagnosis and Management of Dementia: A Narrative Review for Clinical Practice
Kaitlyn Alessi, Charles Sarria, Nehabahen Chauhan, Naushira Pandya, Mayur S. Parmar · 2026 · SN Comprehensive Clinical Medicine
Early treatment with naproxen alters hippocampal metabolites in the TgF344-AD rat model of Alzheimer's disease
Caitlin Fowler, Elena Osipyan, Gabriel A. Devenyi, Dan Madularu, John C.S. Breitner, Jamie Near · 2026 · Neurochemistry International
Chemical probes for Alzheimer’s disease targets
Sheenagh Aiken, Tryfon Zarganes‐Tzitzikas, Paul E. Brennan · 2026 · Essays in Biochemistry
Cell Death in Neurodegenerative Diseases: Molecular Mechanisms and Therapeutic Targets
Tianjiao Li, Qian Zhang, Yichen Wu, Ruixue Huang · 2026 · MedComm
Contribution of G4 Structure to Alzheimer’s Disease and Tau Pathology
Lena M. Kallweit · 2026 · Digital Commons - DU (University of Denver)
Intranasal delivery of nanocarriers for haloperidol: QbD development and pharmacodynamic evaluation in sporadic Alzheimer's disease rat model
Supriya Nikam, Shubham V. Khot, Chandrakant Kokare · 2026 · Journal of Drug Delivery Science and Technology
Ethics of Scientific Research
David B. Resnik · 2026 · Elsevier eBooks
Unlocking the blood–brain barrier: Can low-intensity focused ultrasound enable effective delivery of anti-amyloid and anti-tau antibodies in Alzheimer’s disease?
Desale, Sakshee Hemant, Doshi, Pratik Prashant, Khutale, Aarti Ashok, Suresh, Swathi · 2026 · Ageing Research Reviews
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Adrian Mark Owen · 2026 · Journal of Neurology
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Sam de Leve, Xiangdong Wang, Helia Alavifard, Lily Dara, Laurie D. DeLeve · 2026 · Journal of Biological Chemistry
Repurposing Antidiabetic Drugs in Neurodegenerative Disorders: From Preclinical Mechanisms to Clinical Evidence
Davindra Devi, Ankita Rani, Jiten Singh, Mohammed Nazish Quasmi, Ashok Jangra, Dinesh Kumar · 2026 · SN Comprehensive Clinical Medicine
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Amos D. Korczyn · 2026 · Journal of Alzheimer s Disease
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BindingDB Entry 50018794: Discovery of potent indazole-based human glutaminyl cyclase (QC) inhibitors as Anti-Alzheimer's disease agents.
BindingDB · 2024 · UC San Diego
BindingDB Entry 50022831: A review on synthetic inhibitors of dual-specific tyrosine phosphorylation-regulated kinase 1A (DYRK1A) for the treatment of Alzheimer's disease (AD).
BindingDB · 2026 · UC San Diego
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Xinzhong Li, Illana Gozes · 2026 · Frontiers in Pharmacology
Analysis of New Phase III Therapies, Currently in Clinical Trials, Targeting Alzheimer’s Disease, Various Forms of Dementia and Their Neuropsychiatric Symptoms—A Review of the Specialized Literature
Mihai Grecu, Claudia Simona Ștefan, Lăcrămioara Luminița Apescaritei Apostol, Simona Moldovanu, Alina Pleșea-Condratovici, Andreea Veronica Stavăr, Aurelia Romila · 2026 · Life