Oxidative Stress and Huntington’s Disease: The Good, The Bad, and The Ugly

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Items 101–200 of 236

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2. Cross talk about the role of Neuropeptide Y in CNS disorders and diseases
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3. Baicalein-mediated regulation of Nrf2/ARE, NFĸB, and MAPK signaling in Huntington’s disease: a promising strategy against neuroinflammation and neurodegeneration
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4. Ellagic acid rescues motor and cognitive deficits in the R6/2 mouse model of Huntington's disease by lowering mutant huntingtin protein
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5. The interplay between mitochondrial functionality and genome integrity in the prevention of human neurologic diseases
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6. An antioxidant boehmite amino-nanozyme able to disaggregate Huntington's inclusion bodies
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7. An enquiry to the role of CB1 receptors in neurodegeneration
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8. Reactive Oxygen Species in Neurodegenerative Diseases: Implications in Pathogenesis and Treatment Strategies
   Johnson Olaleye Oladele, Adenike Temidayo Oladiji, Oluwaseun Titilope Oladele, Oyedotun M. Oyeleke · 2021 · Biochemistry
9. In Vivo Nanodiamond Quantum Sensing of Free Radicals in Caenorhabditis elegans Models
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10. Reactive oxygen species in cell signaling and cell death: A redox perspective on metabolic and inflammatory disorders
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11. Preventing Axonal Sodium Overload or Mitochondrial Calcium Uptake Protects Axonal Mitochondria from Oxidative Stress‐Induced Alterations
    Rebecca Ulshöfer, Helena Bros, Anja Erika Hauser, Raluca Aura Niesner, Friedemann Paul, Bimala Malla, Carmen Infante‐Duarte · 2022 · Oxidative Medicine and Cellular Longevity
12. The Possible Roles of β-alanine and L-carnosine in Anti-aging
    Amin Gasmi, Pavan Kumar Mujawdiya, Roman Lysiuk, Mariia Shanaida, Massimiliano Peana, Salva Piscopo, N. M. Beley, S. V. Dzyha, Kateryna Smetanina, Volodymyr Shanaida et al. · 2024 · Current Medicinal Chemistry
13. Neuroprotectant Effects of Hibiscetin in 3-Nitropropionic Acid-Induced Huntington’s Disease via Subsiding Oxidative Stress and Modulating Monoamine Neurotransmitters in Rats Brain
    Wael Ali Mahdi, Shareefa Abdullah AlGhamdi, Amira M. Alghamdi, Syed Sarim Imam, Sultan Alshehri, Mohammad A. Almaniea, Baraa Mohammed Hajjar, Fahad Ahmed Al-Abbasi, Nadeem Sayyed, Imran Ahmed Kazmi · 2023 · Molecules
14. DNA polymerase θ promotes CAG•CTG repeat expansions in Huntington’s disease via insertion sequences of its catalytic domain
    Kara Y. Chan, Xueying Li, Janice Ortega, Liya Gu, Guo‐Min Li · 2021 · Journal of Biological Chemistry
15. An overview about neurological diseases in India – A theranostics approach
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16. 6-shogaol against 3-Nitropropionic acid-induced Huntington’s disease in rodents: Based on molecular docking/targeting pro-inflammatory cytokines/NF-κB-BDNF-Nrf2 pathway
    Ebtihaj Jamaluddin Jambi, Abdulaziz Mohammed Alamri, Muhammad Afzal, Fahad Ahmed Al-Abbasi, Salwa D. Al-Qahtani, Naif A. R. Almalki, Azizah Salim Bawadood, Sami Ibrahim Alzarea, Nadeem Sayyed, Imran Ahmed Kazmi · 2024 · PLoS ONE
17. Study protocol of IMAGINE-HD: Imaging iron accumulation and neuroinflammation with 7T-MRI + CSF in Huntington’s disease
    Nadine A van de Zande, Marjolein Bulk, Chloé Najac, Louise van der Weerd, Jeroen de Bresser, Jan Lewerenz, Itamar Ronen, Susanne Tamara de Bot · 2023 · NeuroImage Clinical
18. Exploring the Therapeutic Potential of BBB ‐Penetrating Phytochemicals With p38 MAPK Modulatory Activity in Addressing Oxidative Stress‐Induced Neurodegenerative Disorders, With a Focus on Alzheimer's Disease
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19. Serum/glucocorticoid regulated kinase 1 (SGK1) in neurological disorders: pain or gain
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20. Protective Effect of Fustin against Huntington’s Disease in 3-Nitropropionic Treated Rats via Downregulation of Oxidative Stress and Alteration in Neurotransmitters and Brain-Derived Neurotrophic Factor Activity
    May Nasser Bin-Jumah, Sadaf Jamal Gilani, Abdulaziz F. Alabbasi, Fahad Ahmed Al-Abbasi, Shareefa Abdullah AlGhamdi, Ohoud Y. Alshehri, Amira M. Alghamdi, Nadeem Sayyed, Imran Ahmed Kazmi · 2022 · Biomedicines
21. Increase in brain glycogen levels ameliorates Huntington's disease phenotype and rescues neurodegeneration in Drosophila
    Akanksha Onkar, S. Deepashree, Anupama Rai, Arjit Gupta, Nitin Gupta, Subramaniam Ganesh · 2023 · Disease Models & Mechanisms
22. Widespread selenium deficiency in the brain of cases with Huntington's disease presents a new potential therapeutic target
    Melissa Scholefield, Stefano Patassini, Jingshu Xu, Garth J. S. Cooper · 2023 · EBioMedicine
23. A step forward in the development of superoxide dismutase mimetic nanozymes: the effect of the charge of the surface on antioxidant activity
    Álvaro Martínez‐Camarena, José Miguel Llinares, Antonio Doménech‐Carbó, Javier Alarcón, Enrique García‐España · 2019 · RSC Advances
24. Investigating Crosstalk Among PTMs Provides Novel Insight Into the Structural Basis Underlying the Differential Effects of Nt17 PTMs on Mutant Httex1 Aggregation
    Anass Chiki, Zhidian Zhang, Kolla Rajasekhar, Luciano A. Abriata, Iman Rostami, Lucien F. Krapp, Driss Boudeffa, Matteo Dal Peraro, Hilal Ahmed Lashuel · 2021 · Frontiers in Molecular Biosciences
25. Mendelian randomization study of coffee consumption and age at onset of Huntington's disease
    Mengmeng Wang, Marilyn C. Cornelis, Zhizhong Zhang, Dandan Liu, Xuegan Lian · 2021 · Clinical Nutrition
26. Fibroblast growth factor 9 reduces TBHP-induced oxidative stress in chondrocytes and diminishes mouse osteoarthritis by activating ERK/Nrf2 signaling pathway.
    Yi Pan, Chao Jia, Jia-Pei Yu, Zhou-wei Wu, Guo-chao Xu, Yi-xing Huang · 2023 · International Immunopharmacology
27. Effect of luteolin on the transgenic Drosophila model of Huntington’s disease
    Yasir Hasan Siddique, Rahul, Himanshi Varshney, I. Mantasha, M. Shahid · 2020 · Computational Toxicology
28. Anti-Huntington’s Effect of Rosiridin via Oxidative Stress/AchE Inhibition and Modulation of Succinate Dehydrogenase, Nitrite, and BDNF Levels against 3-Nitropropionic Acid in Rodents
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29. Rosiglitazone Ameliorates Cardiac and Skeletal Muscle Dysfunction by Correction of Energetics in Huntington’s Disease
    Marta Tomczyk, Alicja Braczko, Paulina Mierzejewska, Magdalena Podlacha, Oliwia Król, Patrycja Jabłońska, Agata Jędrzejewska, Karolina Pierzynowska, Grzegorz Węgrzyn, Ewa Maria Slominska et al. · 2022 · Cells
30. Mutant Huntingtin Derails Cysteine Metabolism in Huntington’s Disease at Both Transcriptional and Post-Translational Levels
    Bindu Diana Paul, Juan I. Sbodio, Solomon H. Snyder · 2022 · Antioxidants
31. Striatal Induction and Spread of the Huntington’s Disease Protein: A Novel Rhes Route
    Srinivasa Subramaniam · 2022 · Journal of Huntington s Disease
32. Xanthine Oxidoreductase: A Double-Edged Sword in Neurological Diseases
    Massimo Bortolotti, Letizia Polito, Maria Giulia Battelli, Andrea Bolognesi · 2025 · Antioxidants
33. Cytotoxicity models of Huntington’s disease and relevance of hormetic mechanisms: A critical assessment of experimental approaches and strategies
    Edward J. Calabrese, Tarun N. Bhatia, Vittorio Calabrese, Gaurav Dhawan, James Giordano, Yannic N. Hanekamp, Rachna Kapoor, Walter J. Kozumbo, Rehana K. Leak · 2019 · Pharmacological Research
34. Neuroprotective Properties of Quinone Reductase 2 Inhibitor M-11, a 2-Mercaptobenzimidazole Derivative
    Михаил Владимирович Воронин, Кадников Илья Андреевич, Лиана Фанзилевна Зайнуллина, Илья Олегович Логвинов, Ekaterina R. Verbovaya, Т. А. Антипова, Yulia V. Vakhitova, С. Б. Середенин · 2021 · International Journal of Molecular Sciences
35. Peripheral Levels of Renin-Angiotensin System Components Are Associated With Cognitive Performance in Huntington’s Disease
    Natália Pessoa Rocha, Courtney Cleary, Gabriela Delevati Colpo, Erin E. Furr-Stimming, Antônio Lúcio Teixeira · 2020 · Frontiers in Neuroscience
36. Bacillus calmette gaurine vaccine ameliorates the neurotoxicity of quinolinic acid in rats via the modulation of antioxidant, inflammatory and apoptotic markers
    Narhari Gangaram Yedke, Richmond Arthur, Puneet Kumar · 2023 · Journal of Chemical Neuroanatomy
37. Small-molecules against Oxidative stress mediated Neurodegenerative diseases
    Chinmay Pal · 2023 · Chemical Biology Letters
38. Impaired Restoration of Global Protein Synthesis Contributes to Increased Vulnerability to Acute ER Stress Recovery in Huntington’s Disease
    Hongyuan Xu, Johanna Bensalel, Enrico Capobianco, Michael L. Lu, Jianning Wei · 2021 · Cellular and Molecular Neurobiology
39. Therapeutic potential of thymoquinone and its nanoformulations in neuropsychological disorders: a comprehensive review on molecular mechanisms in preclinical studies
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40. Emerging role and mechanism of HACE1 in the pathogenesis of neurodegenerative diseases: A promising target
    Caixia Zang, Hui Liu, Jingwen Ning, Qiuzhu Chen, Yueqi Jiang, Meiyu Shang, Yang Yang, Jingwei Ma, Yirong Dong, JinRong Wang et al. · 2024 · Biomedicine & Pharmacotherapy
41. APOBEC3A deaminates CTG hairpin loops to promote fragility and instability of expanded CAG/CTG repeats
    Rebecca E. Brown, Margo Coxon, Benjamin B. Larsen, Maxwell J. Allison, Ariana Chadha, Isabelle Mittelstadt, Tony M. Mertz, Steven A. Roberts, C. Freudenreich · 2025 · Proceedings of the National Academy of Sciences of the United States of America
42. Integrated Bioinformatics Analysis of Shared Genes, miRNA, Biological Pathways and Their Potential Role as Therapeutic Targets in Huntington’s Disease Stages
    Christiana C. Christodoulou, Eleni Zamba Papanicolaou · 2023 · International Journal of Molecular Sciences
43. Potential Role of Oxidative Stress in the Pathophysiology of Neurodegenerative Disorders
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44. The Renin-Angiotensin System in Huntington’s Disease: Villain or Hero?
    Thatiane C. G. Machado, Cristina Guatimosim, Lucas Miranda Kangussu · 2020 · Protein and Peptide Letters
45. The therapeutic potential of (R)-carvedilol in Huntington's disease through enhancement of autophagy-lysosomal pathway via GSK-3β inhibition
    Chih‐Yuan Cheng, Kai-Po Chen, Tien‐Sheng Tseng, Kuo‐Feng Hua, Tz‐Chuen Ju · 2025 · Neurotherapeutics
46. Emerging drivers of DNA repeat expansions
    Liangzi Li, W. Shem Scott, Sergei M. Mirkin · 2025 · Biochemical Society Transactions
47. Brain–Periphery Interactions in Huntington’s Disease: Mediators and Lifestyle Interventions
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48. Intravenous immunoglobulin ameliorates motor and cognitive deficits and neuropathology in R6/2 mouse model of Huntington’s disease by decreasing mutant huntingtin protein level and normalizing NF-κB signaling pathway
    Shuying Liu, Xiaolin Yu, Jie Zhu, Xiang‐meng Liu, Yue Zhang, Quan-xiu Dong, Shan Ma, Rui‐tian Liu · 2018 · Brain Research
49. Single nuclei RNA-seq reveals a medium spiny neuron glutamate excitotoxicity signature prior to the onset of neuronal death in an ovine Huntington’s disease model
    Andrew Jiang, Linya You, Renée R. Handley, Victoria Hawkins, Suzanne J. Reid, Jessie C. Jacobsen, Stefano Patassini, Skye R. Rudiger, Clive J. McLaughlan, Jennifer M. Kelly et al. · 2024 · Human Molecular Genetics
50. Age-Related Oxidative Changes in Primary Porcine Fibroblasts Expressing Mutated Huntingtin
    Petra Šmatlíková, Georgina Askeland, Michaela Vaškovičová, Jiřı́ Klı́ma, Jan Motlík, Lars Eide, Zdeňka Ellederová · 2019 · Neurodegenerative Diseases
51. Advances in Molecular Docking Techniques for Targeting Protein Misfolding in Neurodegenerative Diseases
    Kuldeep Singh, Jeetendra Kumar Gupta, Shiv Narayan, Ketki Rani, Divya Jain, Prateek Porwal, Mukesh Chandra Sharma, Shivendra Kumar · 2025 · Current Pharmaceutical Biotechnology
52. The role of Poly-ADP ribose polymerase (PARP) enzymes in chemotherapy-induced cognitive impairments – parallels with other neurodegenerative disorders
    Dahlia A. Ordaz, Kalpna Gupta, Daniela Annenelie Bota · 2025 · Frontiers in Pharmacology
53. Pathophysiological Mechanisms of Huntington’s Disease
    Zuleide Maria Ignácio, João Quevedo, Gislaine Z. Réus · 2018 · Springer eBooks
54. Characterization of huntingtin interactomes and their dynamic responses in living cells by proximity proteomics
    Hongyuan Xu, Johanna Bensalel, Sunil Raju, Enrico Capobianco, Michael L. Lu, Jianning Wei · 2022 · Journal of Neurochemistry
55. Biological properties and methods for determination of carnosine
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56. Coenzyme Q10: Role in Less Common Age-Related Disorders
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57. Reduction in PA28αβ activation in HD mouse brain correlates to increased mHTT aggregation in cell models
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58. The prospective therapeutic benefits of sesamol: neuroprotection in neurological diseases
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59. Mechanistic Interplay of Gut Microbiota and Blood–Brain Barrier Integrity in Neurodegenerative Diseases
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60. Ferroptosis in microglial activation: a systematic review and multidata comparison
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61. Implicación del estrés oxidativo en las enfermedades neurodegenerativas y posibles terapias antioxidantes
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62. Sesamol: A Phenolic Compound of Health Benefits and Therapeutic Promise in Neurodegenerative Diseases
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63. Emerging Selenium Nanoparticles for CNS Intervention
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64. Small Molecule Pytren-4QMn Metal Complex Slows down Huntington’s Disease Progression in Male zQ175 Transgenic Mice
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65. Oxidative Stress and Cellular Dysfunction in Neurodegenerative Disease
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66. Metabolic deregulation associated with aging modulates protein aggregation in the yeast model of Huntington’s disease
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67. Selective activation of antioxidant resources and energy deficiency in Marinesco–Sjögren syndrome fibroblasts as an adaptive biological response to Sil1 loss
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68. Silymarin ameliorates motor function and averts neuroinflammation-induced cell death in the rat model of Huntington’s disease
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69. Myelinosome organelles in pathological retinas: ubiquitous presence and dual role in ocular proteostasis maintenance
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70. Integrative Analysis Unveils the Correlation of Aminoacyl-tRNA Biosynthesis Metabolites with the Methylation of the SEPSECS Gene in Huntington’s Disease Brain Tissue
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71. Frontiers in neurodegeneration: Biomolecular triggers, diagnostic biomarkers, and smart nanotherapeutics
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72. Insulin resistance and SIRT1 dysregulation in neurodegenerative diseases
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73. 3-Nitropropionic Acid–Induced Huntington’s Disease in Preclinical Models: Mechanisms, Peripheral Toxicities, Model Gaps, and Future Directions
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74. Investigating Holistic Natural Strategies for The Management of Huntington's Disease
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75. Glutathione peroxidase 3 is a potential biomarker for konzo
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76. Apolipoprotein-decorated drug loaded liposomes mitigating copper intoxication: an in vitro and in vivo evidence-based study intervening Wilson disease
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77. Antioxidant Activity of Radix Cyathula officinalis Kuan Polysaccharides and Their Modulatory Effects on the Gut Microbiota of Caenorhabditis elegans
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79. Synthesis, Anticholinesterase and Antioxidant Activity of Thiosemicarbazone Derivatives
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84. Contribution of neuroinflammation, resolution, and neuroprotection in neuropsychiatric diseases
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85. Chief Role of Neuroinflammation and Oxidative Stress in Brain Disorders
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86. Repetitive Transcranial Magnetic Stimulation for Major Depressive Disorder in Huntington Disease Patient with Improvement in Neuropsychiatric and Movement Symptoms: A Case Report
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88. AI-Enhanced Transcriptomic Discovery of Druggable Targets and Repurposed Therapies for Huntington’s Disease
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89. Contribution of neuroinflammation, resolution, and neuroprotection in neurodegenerative diseases
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90. Twist1 Plays an Anti-apoptotic Role in Mutant Huntingtin Expression Striatal Progenitor Cells
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91. Nrf2 as a Potential Therapeutic Target for Treatment of Huntington’s Disease
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92. Antioxidant Gene Expression in Vocal Hindbrain of a Teleost Fish
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96. Mitochondria “Shackled” by Mutant Huntingtin: Analysis of Morphological Alterations and Disruptions of Intracellular Transport
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97. Oxidative stress and inflammation in neurodegenerative disorders
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98. Clinical Use of Antioxidants for the Treatment of Brain Disorders
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99. Biofluid Biomarkers of Amyotrophic Lateral Sclerosis
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100. Huntingtin aggregation at interfaces associated with membranes and organelles
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