The effects of aerobic exercise on sleep quality measures and sleep-related biomarkers in individuals with Multiple Sclerosis: A pilot randomised controlled trial
Open accessAbstract
Background Sleep disturbances are highly prevalent in people with multiple sclerosis(MS), and are associated with pain, fatigue, depression, and reduced quality of life (QoL). Importantly, sleep has been considered a critical brain state for motor learning and memory consolidation. Therefore, interventions that target sleep managementin people with MS are needed. Objectives To explore the effects of a six weeks moderate-intensity aerobic exercise intervention on sleep characteristics and sleep-related biomarkers specifically serotonin, melatoninand cortisol in people with MS using a pilot randomized controlled trial. Methods Participants were randomly allocated to either a moderate-intensity aerobic exercise program (MAE, n = 20) or a home exercise program (HEP, n = 20). Participants were assessed at baseline and follow-up. Subjective and objective measures were used to assess sleep quality. The Pittsburgh Sleep Quality Index (PSQI) and Insomnia Severity Index (ISI) were used to subjectively assess sleep. While Actigraphy was used to objectivelyassess sleep. Blood samples were collected for measurement of cortisol, melatonin and serotonin from MS participants in both groups at 8:00 am±1 hour. Results Seventeen participants in the MAE and 13 in the HEP group completed the study. Compared to the HEP group, people with MS who participated in a moderate-intensity aerobic exercise experienced significant improvements (P Conclusions Exercise may be a non-pharmacological, inexpensiv…
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The effects of physical activity on cortisol and sleep: A systematic review and meta-analysis.
De Nys, L., Anderson, K., Ofosu, E. F., Ryde, G. C., Connelly, J., & Whittaker, A. C. (2022) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2022.105843 · Cited by 279 · see citing works
- Authors
- Al-Sharman, A., Khalil, H., El-Salem, K., Aldughmi, M., & Aburub, A.
- Affiliations
- Department of Rehabilitation Sciences, Jordan University of Science and Technology, Faculty of Applied Medical Sciences, Irbid, Jordan
- Jordan University of Science and Technology (JO)
- Department of Neurosciences, Jordan University of Science and Technology, Faculty of Medicine, Irbid, Jordan
- University of Jordan (JO)
- Keele University (GB)
- Venue
- NeuroRehabilitation
- Publisher
- SAGE Publications
- Published
- 2019-09-25
- Volume
- 45
- Issue
- 1
- Pages
- 107-115
- ISSN
- 1053-8135 (ISSN-L)
- 1878-6448
- OpenAlex
- W2969017509
- Cited by
- 71
- References
- 5
- Citations by year
- 2026: 10 · 2025: 11 · 2024: 8 · 2023: 10 · 2022: 15 · 2021: 11 · 2020: 4 · 2019: 1
- FWCI
- 8.63
- Type
- journal article
- Language
- en
- Open access
- green
- eprints.keele.ac.uk
- Licence
- cc-by
- Locations
- Neurorehabilitation (publishedVersion)
- PubMed (publishedVersion)
- Keele Research Repository (Keele University) (submittedVersion, cc-by)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Keywords
- multiple sclerosis, aerobic exercise, sleep quality, sleep disorders, serotonin, melatonin, cortisol, home exercise program, insomnia, actigraphy, non-pharmacological treatment
- MeSH terms
- Adult, Exercise Therapy, Female, Humans, Sleep Initiation and Maintenance Disorders, Male, Middle Aged, Multiple Sclerosis, Pilot Projects, Quality of Life, Sleep, Biomarkers, Exercise
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