The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
The effect of pore size on permeability and cell attachment in collagen scaffolds for tissue engineering
Open accessAbstract
The permeability of scaffolds and other three-dimensional constructs used for tissue engineering applications is important as it controls the diffusion of nutrients in and waste out of the scaffold as well as influencing the pressure fields within the construct. The objective of this study was to characterize the permeability/fluid mobility of collagen-GAG scaffolds as a function of pore size and compressive strain using both experimental and mathematical modeling techniques. Scaffolds containing four distinct mean pore sizes (151, 121, 110, 96 microns) were fabricated using a freeze-drying process. An experimental device was constructed to measure the permeability of the scaffold variants at different levels of compressive strain (0, 14, 29 and 40% while a low-density open-cell foam cellular solids model utilizing a tetrakaidecahedral unit cell was used to accurately model the permeability of each scaffold variant at all level of applied strain. The results of both the experimental and the mathematical analysis revealed that scaffold permeability increases with increasing pore size and decreases with increasing compressive strain. The excellent comparison between experimentally measured and predicted scaffold permeability suggests that cellular solids modelling techniques can be utilized to predict scaffold permeability under a variety of physiological loading conditions as well as to predict the permeability of future scaffolds with a wide variety of pore microstructures.
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Cites
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Self-citationThe effect of pore size on cell adhesion in collagen-GAG scaffolds
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Self-citationInfluence of freezing rate on pore structure in freeze-dried collagen-GAG scaffolds
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Self-citationDiffusion and Convection in Collagen Gels: Implications for Transport in the Tumor Interstitium
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THE PERMEABILITY OF ARTICULAR CARTILAGE
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Cited by
Biomaterials & scaffolds for tissue engineering
O'Brien, F. J. (2011) · Materials Today · doi:10.1016/s1369-7021(11)70058-x · Cited by 3,437
Self-citationBobbert, F. S. L., Lietaert, K., Eftekhari, A. A., Pouran, B., Ahmadi, S. M., Weinans, H., & Zadpoor, A. A. (2017) · Acta Biomaterialia · doi:10.1016/j.actbio.2017.02.024 · Cited by 873
Functional and Biomimetic Materials for Engineering of the Three-Dimensional Cell Microenvironment
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Mechanical characterization of collagen–glycosaminoglycan scaffolds
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Metadata
- Authors
- O'Brien, F. J., Harley, B. A., Waller, M. A., Yannas, I. V., Gibson, L. J., & Prendergast, P. J.
- Venue
- Technology and Health Care
- Publisher
- SAGE Publications
- Published
- 2006-12-21
- Volume
- 15
- Issue
- 1
- Pages
- 3-17
- ISSN
- 0928-7329 (ISSN-L)
- 1878-7401
- OpenAlex
- W1800455829
- Cited by
- 366
- References
- 20
- FWCI
- 9.66
- Type
- journal article
- Language
- en
- Open access
- green
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