Cited by 323Neural and Behavioral Psychology StudiesChild and Adolescent Psychosocial and Emotional DevelopmentAdolescent Health and Behaviors

Brain Development During Adolescence

Open access
Konrad, Kerstin, Firk, Christine, Uhlhaas, Peter J.·2013·Deutsches Ärzteblatt international

Abstract

BACKGROUND: Adolescence is the phase of life between late childhood and adulthood. Typically, adolescents seek diversion, new experiences, and strong emotions, sometimes putting their health at serious risk. In Germany, for example, 62% of all deaths among persons aged 15 to 20 are due to traumatic injuries. Neuroscientific explanations have been proposed for typical adolescent behavior; with these explanations in mind, one can derive appropriate ways of dealing with adolescents. METHOD: We selectively review pertinent articles retrieved from the PubMed database about the structural and functional development of the brain in adolescence. RESULTS: New findings in developmental psychology and neuroscience reveal that a fundamental reorganization of the brain takes place in adolescence. In postnatal brain development, the maximum density of gray matter is reached first in the primary sensorimotor cortex, and the prefrontal cortex matures last. Subcortical brain areas, especially the limbic system and the reward system, develop earlier, so that there is an imbalance during adolescence between the more mature subcortical areas and less mature prefrontal areas. This may account for typical adolescent behavior patterns, including risk-taking. CONCLUSION: The high plasticity of the adolescent brain permits environmental influences to exert particularly strong effects on cortical circuitry. While this makes intellectual and emotional development possible, it also opens the door to potentially harmful influences.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.3238/arztebl.2013.0425

Cites

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • In particularly emotionally charged situations, such as in the presence of other young people or when there is a possibility of reward, the probability increases that these factors influence adolescents' behaviors more than rationality.

    “Así, en situaciones que son particularmente cargadas emocionalmente (p.ej., en presencia de otros jóvenes o cuando existe posibilidad de una recompensa), aumenta la probabilidad de que estas influyan en sus conductas más que la racionalidad8,9,20 .”

    From Adolescent psychosocial development (2015) · cites this paper as [8]

  • The increased reward or sensation seeking in adolescence would be a product of earlier maturation of the socioemotional brain system than of the cognitive control system, with the result that under emotional arousal the former exceeds the regulatory capacity of the latter, which is still relatively immature.

    “Ello sería producto de la maduración más temprana del sistema cerebral socioemocional que del sistema de control cognitivo, con el resultado de que, en condiciones de excitación emocional, el primero sobrepasa la capacidad regulatoria del segundo (todavía relativamente inmaduro).”

    From Adolescent psychosocial development (2015) · cites this paper as [8]

  • In particularly emotionally charged situations, such as in the presence of other young people or when there is a possibility of reward, the probability increases that these factors influence adolescents' behaviors more than rationality.

    “Así, en situaciones que son particularmente cargadas emocionalmente (p.ej., en presencia de otros jóvenes o cuando existe posibilidad de una recompensa), aumenta la probabilidad de que estas influyan en sus conductas más que la racionalidad8,9,20 .”

    From Adolescent psychosocial development (2015) · cites this paper as [9]

  • In D.'s case, his parents' divorce occurred right at the start of adolescence (13), when the brain is at a permeable state and the sense of identity starts to consolidate.

    “in D.'s case it occurred right in at the start of adolescence (13), when the brain is at a permeable state and the sense of identity starts to consolidate (Konrad et al., 2013)”

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

The citation lists haven’t been fetched yet

References 58 · Cited by 323

Research works printed but not linked: 23

  1. [2]Steinberg L. Risk taking in adolescence: what changes, and why? Annals of the New York Academy of Sciences. 2004;1021:51–58. doi: 10.1196/annals.1308.005. [DOI] [PubMed] [Google Scholar] · DOI · Paper page
  2. [3]Steinberg L. A social neuroscience perspective on adolescent risk-taking. Developmental Review. 2008;28:78–106. doi: 10.1016/j.dr.2007.08.002. [DOI] [PMC free article] [PubMed] [Google Scholar] · DOI · Paper page
  3. [4]Eaton DK, Kann L, Kinchen S, et al. Youth risk behavior surveillance—United States, 2005. Morbidity and mortality weekly report. Surveillance Summaries. 2006;55:1–108. [PubMed] [Google Scholar]
  4. [6]Mason C. The development of developmental neuroscience. The Journal of Neuroscience: the official journal of the Society for Neuroscience. 2009;29:12735–12747. doi: 10.1523/JNEUROSCI.4648-09.2009. [DOI] [PMC free article] [PubMed] [Google Scholar] · DOI
  5. [7]Giedd JN, Blumenthal J, Jeffries NO, et al. Brain development during childhood and adolescence: a longitudinal MRI study. Nature Neuroscience. 1999;2:861–863. doi: 10.1038/13158. [DOI] [PubMed] [Google Scholar] · DOI · Paper page
  6. [8]Huttenlocher PR, Dabholkar AS. Regional differences in synaptogenesis in human cerebral cortex. J Comp Neurol. 1997;387:167–178. doi: 10.1002/(sici)1096-9861(19971020)387:2<167::aid-cne1>3.0.co;2-z. [DOI] [PubMed] [Google Scholar] · DOI
  7. [10]Yakovlev PA, Lecours IR. The myelogenetic cycles of regional maturation of the brain. In: Minkowski A, editor. Regional development of the brain in early life. Oxford: Blackwell; 1967. pp. 3–70. [Google Scholar]
  8. [11]Murrin LC, Sandersm JD, Bylund DB. Comparison of the maturation of the adrenergic and serotonergic neurotransmitter systems in the brain: implications for differential drug effects on juveniles and adults. Biochemical Pharmacology. 2007;73:1225–1236. doi: 10.1016/j.bcp.2007.01.028. [DOI] [PMC free article] [PubMed] [Google Scholar] · DOI
  9. [14]Singer W. Dynamic formation of functional networks by synchronization. Neuron. 2011;69:191–193. doi: 10.1016/j.neuron.2011.01.008. [DOI] [PubMed] [Google Scholar] · DOI
  10. [16]Konrad K. Strukturelle Hirnentwicklung in der Adoleszenz. In: Uhlhaas PJ, Konrad K, editors. Das adoleszente Gehirn. Stuttgart: Kohlhammer; 2011. pp. 124–138. [Google Scholar]
  11. [17]Huttenlocher PR. Synaptogenesis in human cerebral cortex. In: Dawson G, Fischer KW, editors. Human behavior and the developing brain. New York: Guilford Press; 1994. [Google Scholar]
  12. [18]Paus T, Keshavan M, Giedd JN. Why do many psychiatric disorders emerge during adolescence? Nature reviews. Neuroscience. 2008;9:947–957. doi: 10.1038/nrn2513. [DOI] [PMC free article] [PubMed] [Google Scholar] · DOI · Paper page
  13. [19]Reiss AL, Abrams MT, Singer HS, Ross JL, Denckla MB. Brain development, gender and IQ in children. A volumetric imaging study. Brain. 1996;119:1763–1774. doi: 10.1093/brain/119.5.1763. [DOI] [PubMed] [Google Scholar] · DOI
  14. [23]Galvan A, Hare TA, Parra CE, et al. Earlier development of the accumbens relative to orbitofrontal cortex might underlie risk-taking behavior in adolescents. J Neurosc. 2006;26:6885–6892. doi: 10.1523/JNEUROSCI.1062-06.2006. [DOI] [PMC free article] [PubMed] [Google Scholar] · DOI · Paper page
  15. [26]Nagy Z, Westerberg H, Klingberg T. Maturation of white matter is associated with the development of cognitive functions during childhood. Journal of Cognitive Neuroscience. 2004;16:1227–1233. doi: 10.1162/0898929041920441. [DOI] [PubMed] [Google Scholar] · DOI · Paper page
  16. [27]Whittle S, Yap MB, Yucel M, et al. Prefrontal and amygdala volumes are related to adolescents’ affective behaviors during parent-adolescent interactions. Proceedings of the National Academy of Sciences of the United States of America. 2008;105:3652–3657. doi: 10.1073/pnas.0709815105. [DOI] [PMC free article] [PubMed] [Google Scholar] · DOI · Paper page
  17. [30]Geier CF, Terwilliger R, Teslovich T, Velanova K, Luna B. Immaturities in reward processing and its influence on inhibitory control in adolescence. Cerebral Cortex. 2010;20:1613–1629. doi: 10.1093/cercor/bhp225. [DOI] [PMC free article] [PubMed] [Google Scholar] · DOI · Paper page
  18. [31]van Leijenhorst L, Zanolie K, Van Meel CS, Westenberg PM, Rombouts SA, Crone EA. What motivates the adolescent? Brain regions mediating reward sensitivity across adolescence. Cerebral Cortex. 2010;20:61–69. doi: 10.1093/cercor/bhp078. [DOI] [PubMed] [Google Scholar] · DOI · Paper page
  19. [34]Romer D. Reducing adolescent risk: toward an integrated approach 2003. Thousand Oaks: Sage Publications. 2003 [Google Scholar]
  20. [35]Spear LP. The adolescent brain and age-related behavioral manifestations. Neuroscience and Biobehavioral Reviews. 2000;24(4):417–463. doi: 10.1016/s0149-7634(00)00014-2. [DOI] [PubMed] [Google Scholar] · DOI · Paper page
  21. [37]Naninck EF, Lucassen PJ, Bakker J. Sex differences in adolescent depression: do sex hormones determine vulnerability? Journal of Neuroendocrinology. 2011;23:383–392. doi: 10.1111/j.1365-2826.2011.02125.x. [DOI] [PubMed] [Google Scholar] · DOI
  22. [38]Schneider M. Puberty as a highly vulnerable developmental period for the consequences of cannabis exposure. Addiction Biology. 2008;13:253–263. doi: 10.1111/j.1369-1600.2008.00110.x. [DOI] [PubMed] [Google Scholar] · DOI
  23. [39]Bühler A. Risikoverhalten in der Jugend. In: Uhlhaas PJ, Konrad K, editors. Strukturelle Hirnentwicklung in der Adoleszenz. Stuttgart: Kohlhammer; 2011. pp. 189–205. [Google Scholar]

Authors
Konrad, K., Firk, C., & Uhlhaas, P. J.
Affiliations
Forschungszentrum Jülich (DE)
Venue
Deutsches Ärzteblatt international
Published
2013-06-21
Volume
110
Issue
25
Pages
425-31
ISSN
1866-0452 (ISSN-L)
OpenAlex
W1579693295
Cited by
323
References
58
Citations by year
2026: 23 · 2025: 30 · 2024: 24 · 2023: 38 · 2022: 28 · 2021: 45 · 2020: 21 · 2019: 24 · 2018: 26 · 2017: 18 · 2016: 9 · 2015: 11 · 2014: 13 · 2013: 12 · 2012: 1
FWCI
1.27
Type
journal article
Language
de
Open access
Locations
  • Deutsches Ärzteblatt international (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
  • Health Sciences › Health Professions › General Health Professions › Adolescent Health and Behaviors
Keywords
adolescent brain development, prefrontal cortex maturation, gray matter density, limbic system, reward systems, risk-taking, adolescent behavior, neuroplasticity, cortical circuits
MeSH terms
Adolescent, Adolescent Behavior, Aging, Brain, Female, Humans, Male, Models, Neurological, Neuronal Plasticity, Reward, Risk-Taking

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review