The DOI matches its Crossref record, with a small difference in title or year; 39 of the 39 references it cites were found in a registry or an index.
Inhibition of USP1, a new partner of Bcr-Abl, results in decrease of Bcr-Abl level in K562 cells
Open accessAbstract
AIM: To analyze interaction of ubiquitin specific peptidase 1 (USP1) with Bcr-Abl and to assess the relation between USP1 functional activity and Bcr-Abl expression in K562 chronic myeloid leukemia cells. MATERIALS AND METHODS: The interaction between USP1 and Bcr-Abl in K562 cells was analyzed by co-immunoprecipitation, Western blot analysis, and confocal microscopy. RESULTS: A direct interaction between Bcr-Abl oncoprotein and USP1 protein in K562 cells was established by co-immunoprecipitation. Immunofluorescence analysis and confocal microscopy revealed that Bcr-Abl/USP1 protein complex is formed in the cell nucleus. The inhibition of USP1 protein activity by ML323 reduced the level of Bcr-Abl oncoprotein in K562 cells. CONCLUSIONS: USP1 protein has been identified as a new protein partner of Bcr-Abl oncoprotein in chronic myeloid leukemia. The relationship between the functional activity of USP1 protein and the level of Bcr-Abl oncoprotein has been demonstrated, suggesting that the targeted inhibition of USP1 activity could be a challenging approach for reducing Bcr-Abl expression.
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“These stressed mice also exhibited a higher expression of SASP, CREB, NF-κB, and AP-1 genes.”
From Comprehensive review of chronic stress pathways and the efficacy of behavioral stress reduction programs (BSRPs) in managing diseases. (2024) · cites this paper as [53]
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“In a study involving male SCID mice subjected to 14 days of restraint stress, researchers observed an increased expression of aging markers such as p16INK4a and p21, alongside reduced DNA damage repair capabilities.”
From Comprehensive review of chronic stress pathways and the efficacy of behavioral stress reduction programs (BSRPs) in managing diseases. (2024) · cites this paper as [53]
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“The findings suggest that chronic stress can significantly affect biological aging pathways, particularly within bone marrow leukocytes, potentially mediated by sympathetic beta-adrenergic receptor activation.”
From Comprehensive review of chronic stress pathways and the efficacy of behavioral stress reduction programs (BSRPs) in managing diseases. (2024) · cites this paper as [53]
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A practical guide to evaluating colocalization in biological microscopy
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Shchaslyvyi, A. Y., Antonenko, S. V., & Telegeev, G. D. (2024) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph21081077 · Cited by 73
Self-citation
Metadata
- Authors
- Antonenko, S. V., & Telegeev, G. D.
- Affiliations
- Institute of Molecular Biology and Genetics (UA)
- Venue
- Experimental Oncology
- Published
- 2023-06-01
- Volume
- 42
- Issue
- 2
- Pages
- 109-114
- ISSN
- 0204-3564 (ISSN-L)
- 2312-8852
- 1812-9269
- OpenAlex
- W3038319487
- Cited by
- 19
- References
- 39
- Citations by year
- 2026: 5 · 2025: 2 · 2024: 4 · 2023: 4
- FWCI
- 1.26
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Experimental Oncology (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Chronic Myeloid Leukemia Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
- Keywords
- USP1, BCR-ABL, chronic myeloid leukemia, K562 cells, protein-protein interaction, nuclear protein complex, targeted therapy
- MeSH terms
- Cell Nucleus, Humans, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Fusion Proteins, bcr-abl, K562 Cells, Ubiquitin-Specific Proteases
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