A heterologous virus-vectored vaccine for prevention of Middle East respiratory syndrome induces long protective immune response against MERS-CoV

Kovyrshina, A.V.; Federal Research Centre of Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, Ministry of Healthcare of the Russian Federation; Dolzhikova, I.V.; Federal Research Centre of Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, Ministry of Healthcare of the Russian Federation; Grousova, D.M.; Federal Research Centre of Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, Ministry of Healthcare of the Russian Federation; Balyasin, M.V.; Federal Research Centre of Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, Ministry of Healthcare of the Russian Federation; Botikov, A.G.; Federal Research Centre of Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, Ministry of Healthcare of the Russian Federation; Panina, L.V.; Federal Research Centre of Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, Ministry of Healthcare of the Russian Federation; Gordeychuk, I.V.; Federal Research Centre of Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, Ministry of Healthcare of the Russian Federation; I.M. Sechenov First Moscow State Medical University of Ministry of Healthcare of the Russian Federation (Sechenov University); Chumakov Federal Scientifi c Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences; Gulyaev, S.A.; Chumakov Federal Scientifi c Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences; Zubkova, O.V.; Federal Research Centre of Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, Ministry of Healthcare of the Russian Federation; Ozharovskaya, T.A.; Federal Research Centre of Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, Ministry of Healthcare of the Russian Federation; Popova, O.; Federal Research Centre of Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, Ministry of Healthcare of the Russian Federation; Tukhvatulin, A.I.; Federal Research Centre of Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, Ministry of Healthcare of the Russian Federation; Tokarskaya, E.A.; Federal Research Centre of Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, Ministry of Healthcare of the Russian Federation; Simakova, Ya.V.; Federal Research Centre of Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, Ministry of Healthcare of the Russian Federation; Esmagambetov, I.B.; Federal Research Centre of Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, Ministry of Healthcare of the Russian Federation; Shcheblyakov, D.V.; Federal Research Centre of Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, Ministry of Healthcare of the Russian Federation; Evgrafova, I.M.; Federal Research Centre of Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, Ministry of Healthcare of the Russian Federation; Deryabin, P.G.; Federal Research Centre of Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, Ministry of Healthcare of the Russian Federation; Borisevich, S.V.; 48 Central Research Institute, Ministry of Defense of the Russian Federation; Naroditsky, B.S.; Federal Research Centre of Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, Ministry of Healthcare of the Russian Federation; I.M. Sechenov First Moscow State Medical University of Ministry of Healthcare of the Russian Federation (Sechenov University); Logunov, D.Yu.; Federal Research Centre of Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, Ministry of Healthcare of the Russian Federation; Gintsburg, A.L.; Federal Research Centre of Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, Ministry of Healthcare of the Russian Federation; I.M. Sechenov First Moscow State Medical University of Ministry of Healthcare of the Russian Federation (Sechenov University)

doi:10.33029/0206-4952-2020-41-2-135-143

Cited by 13SARS-CoV-2 and COVID-19 ResearchAnimal Virus Infections StudiesPoxvirus research and outbreaks

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A heterologous virus-vectored vaccine for prevention of Middle East respiratory syndrome induces long protective immune response against MERS-CoV

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Kovyrshina, A.V., Federal Research Centre of Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, Ministry of Healthcare of the Russian Federation, Dolzhikova, I.V., Federal Research Centre of Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, Ministry of Healthcare of the Russian Federation, Grousova, D.M., Federal Research Centre of Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, Ministry of Healthcare of the Russian Federation, Balyasin, M.V., Federal Research Centre of Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, Ministry of Healthcare of the Russian Federation, Botikov, A.G., Federal Research Centre of Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, Ministry of Healthcare of the Russian Federation, Panina, L.V., Federal Research Centre of Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, Ministry of Healthcare of the Russian Federation, Gordeychuk, I.V., Federal Research Centre of Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, Ministry of Healthcare of the Russian Federation, I.M. Sechenov First Moscow State Medical University of Ministry of Healthcare of the Russian Federation (Sechenov University), Chumakov Federal Scientifi c Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences, Gulyaev, S.A., Chumakov Federal Scientifi c Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences, Zubkova, O.V., Federal Research Centre of Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, Ministry of Healthcare of the Russian Federation, Ozharovskaya, T.A., Federal Research Centre of Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, Ministry of Healthcare of the Russian Federation, Popova, O., Federal Research Centre of Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, Ministry of Healthcare of the Russian Federation, Tukhvatulin, A.I., Federal Research Centre of Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, Ministry of Healthcare of the Russian Federation, Tokarskaya, E.A., Federal Research Centre of Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, Ministry of Healthcare of the Russian Federation, Simakova, Ya.V., Federal Research Centre of Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, Ministry of Healthcare of the Russian Federation, Esmagambetov, I.B., Federal Research Centre of Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, Ministry of Healthcare of the Russian Federation, Shcheblyakov, D.V., Federal Research Centre of Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, Ministry of Healthcare of the Russian Federation, Evgrafova, I.M., Federal Research Centre of Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, Ministry of Healthcare of the Russian Federation, Deryabin, P.G., Federal Research Centre of Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, Ministry of Healthcare of the Russian Federation, Borisevich, S.V., 48 Central Research Institute, Ministry of Defense of the Russian Federation, Naroditsky, B.S., Federal Research Centre of Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, Ministry of Healthcare of the Russian Federation, I.M. Sechenov First Moscow State Medical University of Ministry of Healthcare of the Russian Federation (Sechenov University), Logunov, D.Yu., Federal Research Centre of Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, Ministry of Healthcare of the Russian Federation, Gintsburg, A.L., Federal Research Centre of Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, Ministry of Healthcare of the Russian Federation, I.M. Sechenov First Moscow State Medical University of Ministry of Healthcare of the Russian Federation (Sechenov University)·2020·Immunologiya

DOI 10.33029/0206-4952-2020-41-2-135-143

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Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia
Zaki, A. M., van Boheemen, S., Bestebroer, T. M., Osterhaus, A. D. M. E., & Fouchier, R. A. M. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1211721 · Cited by 5,677
Correlates of protection induced by vaccination
Plotkin, S. A. (2010) · Clinical and Vaccine Immunology · doi:10.1128/cvi.00131-10 · Cited by 1,745
Commentary: Middle East Respiratory Syndrome Coronavirus (MERS-CoV): Announcement of the Coronavirus Study Group
de Groot, R. J., Baker, S. C., Baric, R. S., Brown, C. S., Drosten, C., Enjuanes, L., Fouchier, R. A. M., Galiano, M., Gorbalenya, A. E., Memish, Z. A., et al. (2013) · Journal of Virology · doi:10.1128/jvi.01244-13 · Cited by 1,238
Imported chikungunya cases in an area newly colonised by Aedes albopictus: mathematical assessment of the best public health strategy
Sochacki, T., Jourdain, F., Perrin, Y., Noël, H., Paty, M.-C., de Valk, H., Septfons, A., Simard, F., Fontenille, D., & Roche, B. (2016) · Eurosurveillance · doi:10.2807/1560-7917.es.2016.21.18.30221 · Cited by 750
Heterologous prime-boost vaccination
Lu, S. (2009) · Current Opinion in Immunology · doi:10.1016/j.coi.2009.05.016 · Cited by 481
Middle East Respiratory Syndrome Coronavirus (MERS-CoV)
Jolly, G. (2016) · Texila international journal of public health · doi:10.21522/tijph.2013.04.04.art033 · Cited by 452
Human Infection with MERS Coronavirus after Exposure to Infected Camels, Saudi Arabia, 2013
Memish, Z. A., Cotten, M. L., Meyer, B., Watson, S. J., Alsahafi, A. J., Rabeeah, A. A. A., Corman, V. M., Sieberg, A., Makhdoom, H. Q., Assiri, A. M., et al. (2014) · Emerging infectious diseases · doi:10.3201/eid2006.140402 · Cited by 360
Middle East respiratory syndrome coronavirus (MERS-CoV) RNA and neutralising antibodies in milk collected according to local customs from dromedary camels, Qatar, April 2014
Reusken, C. B. E. M., Farag, E., Jonges, M., Godeke, G.-J., Elsayed, A. M. A., Pas, S. D., Raj, V. S., Mohran, K. A., MOUSSA, H. A. A., Ghobashy, H. M., et al. (2014) · Eurosurveillance · doi:10.2807/1560-7917.es2014.19.23.20829 · Cited by 173
Safety and immunogenicity of GamEvac-Combi, a heterologous VSV- and Ad5-vectored Ebola vaccine: an open phase I/II trial in healthy adults in Russia
Dolzhikova, I. V., Zubkova, O. V., Tukhvatulin, A. I., Dzharullaeva, A. S., Tukhvatulina, N. M., Shcheblyakov, D. V., Shmarov, M. M., Tokarskaya, E. A., Simakova, Y. V., Egorova, D. A., et al. (2017) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2016.1238535 · Cited by 132
Self-citation
Single intranasal immunization with chimpanzee adenovirus-based vaccine induces sustained and protective immunity against MERS-CoV infection
Jia, W., Channappanavar, R., Zhang, C., Li, M., Zhou, H., Zhang, S., Zhou, P.-P., Xu, J., Shan, S., Shi, X., et al. (2019) · Emerging Microbes & Infections · doi:10.1080/22221751.2019.1620083 · Cited by 45

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Show all 11 references

Research works printed but not linked: 15

Zaki A.M., van Boheemen., Bestebroer T.M., Osterhaus A.D., Fouchier R.A. Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia [published correction appears in N. Engl. J. Med. 2013; 369 (4): 394].
World Health Organisation. WHO Research and Develop- ment Blueprint: 2017 Annual review of diseases prioritized under the Research and Development Blueprint. 2017. URL: http://www.who. int/blueprint/what/research-development/2017-Prioritization-Long- Report.pdf. (дата обращения: 19.03.20)
Медуницын Н.В. Проблемы коррекции иммунитета при вакцинации. Иммунология. 2017; 38 (3): 148-54. DOI: 10.18821/ 0206-4952-2017-38-3-148-154. · DOI
de Groot R.J., Baker S.C., Baric R.S., Brown C.S., Drosten C., Enjuanes L., et al. Middle East respiratory syndrome coronavirus (MERS-CoV): announcement of the Coronavirus Study Group. J. Vi- rol. 2013; 87 (14): 7790-2. DOI: 10.1128/JVI.01244-13. · DOI
Zaki A.M., van Boheemen., Bestebroer T.M., Osterhaus A.D., Fouchier R.A. Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia [published correction appears in N. Engl. J. Med. 2013; 369 (4): 394].
N. Engl. J. Med. 2012; 367 (19): 1814-20. DOI: 10.1056/NEJMoa1211721. · DOI
Memish Z.A., Cotten M., Meyer B., Watson S.J., Alsahafi A.J., Al Rabeeah A.A., et al. Human infection with MERS coronavirus after exposure to infected camels, Saudi Arabia, 2013. Emerg. Infect. Dis. 2014; 20 (6): 1012-5. DOI: 10.3201/eid2006.140402. · DOI
Reusken C.B., Farag E.A., Jonges M., Godeke G.J., El-Sayed A.M., Pas S.D., et al. Middle East respiratory syndrome coronavirus (MERS-CoV) RNA and neutralising antibodies in milk collected ac- cording to local customs from dromedary camels, Qatar, April 2014. Euro Surveill. 2014; 19 (23): 208-29. DOI: 10.2807/1560-7917. ES2014.19.23.20829. · DOI
Cho H., Excler J.L., Kim J.H., Yoon I.K. Development of Middle East Respiratory Syndrome Coronavirus vaccines -advances and challenges. Hum. Vaccines Immunother. 2018; 14 (2): 304-13. DOI: 10.1080/21645515.2017.1389362. · DOI
Lu S. Heterologous prime-boost vaccination. Curr. Opin. Im- munol. 2009; 21 (3): 346-51. DOI: 10.1016/j.coi.2009.05.016. · DOI · Paper page
Dolzhikova I.V., Zubkova O.V., Tukhvatulin A.I., Dzharul- laeva A.S., Tukhvatulina N.M., Shcheblyakov D.V., et al. Safety and immunogenicity of GamEvac-Combi, a heterologous VSV-and Ad5-vectored Ebola vaccine: An open phase I/II trial in healthy adults in Russia. Hum. Vaccines Immunother. 2017; 13 (3): 613-20. DOI: 10.1080/21645515.2016.1238535. · DOI · Paper page
Leonova V.P. (ed.). Moscow: GEOTAR-Media, 2015. (in Russian)
Plotkin S.A. Correlates of protection induced by vaccina- tion. Clin. Vaccine Immunol. 2010; 17 (7): 1055-65. DOI: 10.1128/ CVI.00131-10. · DOI · Paper page
Medunitsyn N.V. The problem of correction of immunity in vac- cination center of expertise of medical application. Immunologiya. 2017; 38 (3): 148-54. DOI: 10.18821/0206-4952-2017-38-3-148-154. (in Russian) · DOI
Jia W., Channappanavar R., Zhang C., Li M., Zhou H., Zhang S., et al. Single intranasal immunization with chimpanzee adenovirus- based vaccine induces sustained and protective immunity against MERS-CoV infection. Emerg. Microbes Infect. 2019; 8 (1): 760-72. DOI: 10.1080/22221751.2019.1620083. · DOI

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Logunov, D. Y., Dolzhikova, I. V., Shcheblyakov, D. V., Tukhvatulin, A. I., Zubkova, O. V., Dzharullaeva, A. S., Kovyrshina, A. V., Lubenets, N. L., Grousova, D. M., Erokhova, A. S., et al. (2021) · The Lancet · doi:10.1016/s0140-6736(21)00234-8 · Cited by 1,747
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Authors: Kovyrshina, A. V., Federal Research Centre of Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, M. O. H. O. T. R. F., Dolzhikova, I. V., Federal Research Centre of Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, M. O. H. O. T. R. F., Grousova, D. M., Federal Research Centre of Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, M. O. H. O. T. R. F., Balyasin, M. V., Federal Research Centre of Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, M. O. H. O. T. R. F., Botikov, A. G., Federal Research Centre of Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, M. O. H. O. T. R. F., Panina, L. V., Federal Research Centre of Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, M. O. H. O. T. R. F., Gordeychuk, I. V., Federal Research Centre of Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, M. O. H. O. T. R. F., I.M. Sechenov First Moscow State Medical University of Ministry of Healthcare of the Russian Federation (Sechenov University), Chumakov Federal Scientifi c Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences, Gulyaev, S. A., Chumakov Federal Scientifi c Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences, Zubkova, O. V., Federal Research Centre of Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, M. O. H. O. T. R. F., Ozharovskaya, T. A., Federal Research Centre of Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, M. O. H. O. T. R. F., Popova, O., Federal Research Centre of Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, M. O. H. O. T. R. F., Tukhvatulin, A. I., Federal Research Centre of Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, M. O. H. O. T. R. F., Tokarskaya, E. A., Federal Research Centre of Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, M. O. H. O. T. R. F., Simakova, Y. V., Federal Research Centre of Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, M. O. H. O. T. R. F., Esmagambetov, I. B., Federal Research Centre of Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, M. O. H. O. T. R. F., Shcheblyakov, D. V., Federal Research Centre of Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, M. O. H. O. T. R. F., Evgrafova, I. M., Federal Research Centre of Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, M. O. H. O. T. R. F., Deryabin, P. G., Federal Research Centre of Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, M. O. H. O. T. R. F., Borisevich, S. V., 48 Central Research Institute, M. O. D. O. T. R. F., Naroditsky, B. S., Federal Research Centre of Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, M. O. H. O. T. R. F., I.M. Sechenov First Moscow State Medical University of Ministry of Healthcare of the Russian Federation (Sechenov University), Logunov, D. Y., Federal Research Centre of Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, M. O. H. O. T. R. F., Gintsburg, A. L., Federal Research Centre of Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, M. O. H. O. T. R. F., & I.M. Sechenov First Moscow State Medical University of Ministry of Healthcare of the Russian Federation (Sechenov University)
Affiliations: Russian Academy of Sciences (RU)
Gamalei Institute of Epidemiology and Microbiology (RU)
Corresponding author: Gulyaev, S.A.
Naroditsky, B.S.
ORCID: Dolzhikova, I.V.
Grousova, D.M.
Balyasin, M.V.
Botikov, A.G.
Panina, L.V.
Gordeychuk, I.V.
Gulyaev, S.A.
Zubkova, O.V.
Popova, O.
Esmagambetov, I.B.
Shcheblyakov, D.V.
Deryabin, P.G.
Borisevich, S.V.
Naroditsky, B.S.
Logunov, D.Yu.
Venue: Immunologiya
Publisher: Geotar-Media Publishing Group
Published: 2020
Volume: 41
Issue: 2
Pages: 135-143
ISSN: 0206-4952 (ISSN-L)
2412-1312
DOI: 10.33029/0206-4952-2020-41-2-135-143
OpenAlex: W3075666614
Cited by: 13
References: 11
Citations by year: 2025: 1 · 2022: 2 · 2021: 8 · 2020: 2
FWCI: 0.43
Type: journal article
Language: en
Open access: diamond
doi.org
Licence: cc-by
Locations: Immunologiya (publishedVersion, cc-by)
Funders: Ministry of Health of the Russian Federation
Topics: Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Virus Infections Studies
Life Sciences › Immunology and Microbiology › Virology › Poxvirus research and outbreaks
Keywords: heterologous vaccine, MERS, MERS-CoV, vaccine-induced immunity, protective immune response, vaccine development

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A heterologous virus-vectored vaccine for prevention of Middle East respiratory syndrome induces long protective immune response against MERS-CoV

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