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Cited by 831

The DOI matches its Crossref record; 112 of the 112 references it cites were found in a registry or an index.

Treatment of renal cell carcinoma: Current status and future directions

Open access
Barata, Pedro C., Rini, Brian I.·2017·CA: A Cancer Journal for Clinicians

Abstract

Answer questions and earn CME/CNE Over the past 12 years, medical treatment for renal cell carcinoma (RCC) has transitioned from a nonspecific immune approach (in the cytokine era), to targeted therapy against vascular endothelial growth factor (VEGF), and now to novel immunotherapy agents. Multiple agents—including molecules against vascular endothelial growth factor, platelet‐derived growth factor, and related receptors; inhibitors of other targets, such as the mammalian target of rapamycin and the MET and AXL tyrosine‐protein kinase receptors; and an immune‐checkpoint inhibitor—have been approved based on significant activity in patients with advanced RCC. Despite these advances, important questions remain regarding biomarkers of efficacy, patient selection, and the optimal combination and sequencing of agents. The purpose of this review is to summarize present management and future directions in the treatment of metastatic RCC. CA Cancer J Clin 2017;67:507‐524. © 2017 American Cancer Society.

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Metadata

Authors
Barata, P. C., & Rini, B. I.
Venue
CA: A Cancer Journal for Clinicians
Publisher
Wiley
Published
2017-09-29
Volume
67
Issue
6
Pages
507-524
ISSN
  • 0007-9235 (ISSN-L)
  • 1542-4863
OpenAlex
W2757487320
Cited by
831
References
112
FWCI
38.88
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: Treatment of renal cell carcinoma: Current status and future directions. https://app.cochat.ai/papers/10.3322/caac.21411
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Barata, P. C., & Rini, B. I. (2017). Treatment of renal cell carcinoma: Current status and future directions. CA: A Cancer Journal for Clinicians. https://doi.org/10.3322/caac.21411

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.