The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
SOX11 expression is highly specific for mantle cell lymphoma and identifies the cyclin D1-negative subtype
Open accessAbstract
BACKGROUND: Cyclin D1-negative mantle cell lymphoma is difficult to distinguish from other small B-cell lymphomas. The clinical and pathological characteristics of patients with this form of lymphoma have not been well defined. Overexpression of the transcription factor SOX11 has been observed in conventional mantle cell lymphoma. The aim of this study was to determine whether this gene is expressed in cyclin D1-negative mantle cell lymphoma and whether its detection may be useful to identify these tumors. DESIGN AND METHODS: The microarray database of 238 mature B-cell neoplasms was re-examined. SOX11 protein expression was investigated immunohistochemically in 12 cases of cyclin D1-negative mantle cell lymphoma, 54 cases of conventional mantle cell lymphoma, and 209 additional lymphoid neoplasms. RESULTS: SOX11 mRNA was highly expressed in conventional and cyclin D1-negative mantle cell lymphoma and in 33% of the cases of Burkitt's lymphoma but not in any other mature lymphoid neoplasm. SOX11 nuclear protein was detected in 50 cases (93%) of conventional mantle cell lymphoma and also in the 12 cyclin D1-negative cases of mantle cell lymphoma, the six cases of lymphoblastic lymphomas, in two of eight cases of Burkitt's lymphoma, and in two of three T-prolymphocytic leukemias but was negative in the remaining lymphoid neoplasms. Cyclin D2 and D3 mRNA levels were significantly higher in cyclin D1-negative mantle cell lymphoma than in conventional mantle cell lymphoma but the protein expression was not discriminative. The clinico-pathological features and outcomes of the patients with cyclin D1-negative mantle cell lymphoma identified by SOX11 expression were similar to those of patients with conventional mantle cell lymphoma. CONCLUSIONS: SOX11 mRNA and nuclear protein expression is a highly specific marker for both cyclin D1-positive and negative mantle cell lymphoma.
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Rosenwald, A., Wright, G., Wiestner, A., Chan, W. C., Connors, J. M., Campo, E., Gascoyne, R. D., Grogan, T. M., Muller-Hermelink, H. K., Smeland, E. B., et al. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00028-x · Cited by 914
Self-citationJares, P., Colomer, D., & Campo, E. (2007) · Nature Reviews Cancer · doi:10.1038/nrc2230 · Cited by 466
Self-citationFu, K. (2005) · Blood · doi:10.1182/blood-2005-04-1753 · Cited by 346
Self-citationBeà, S., Ribas, M., Hernández‐Rivas, J. M., Bosch, F., Pinyol, M., Hernández, L., Garcı́a, J. L., Flores, T., González, M., López‐Guillermo, A., et al. (1999) · PubMed · doi:10.1182/blood.v93.12.4365 · Cited by 284
Self-citationHomozygous deletions localize novel tumor suppressor genes in B-cell lymphomas
Mestre-Escorihuela, C., Rubio-Moscardo, F., Richter, J. A., Siebert, R., Climent, J., Fresquet, V., Beltran, E., Agirre, X., Marugan, I., Marín, M., et al. (2007) · Blood · doi:10.1182/blood-2006-06-026500 · Cited by 246
Self-citationEk, S., Dictor, M., Jerkeman, M., Jirström, K., & Borrebaeck, C. A. K. (2008) · Blood · doi:10.1182/blood-2007-06-093401 · Cited by 204
Salaverria, I., Zettl, A., Beà, S., Moreno, V., Valls, J., Hartmann, E., Ott, G., Wright, G., Lopez-Guillermo, A., Chan, W. C., et al. (2007) · Journal of Clinical Oncology · doi:10.1200/jco.2006.08.4251 · Cited by 181
Self-citationRizzatti, E. G., Falcão, R. P., Panepucci, R. A., Proto‐Siqueira, R., Anselmo‐Lima, W. T., Okamoto, O. K., & Zago, M. A. (2005) · British Journal of Haematology · doi:10.1111/j.1365-2141.2005.05630.x · Cited by 164
Cyclin D3 is a target gene of t(6;14)(p21.1;q32.3) of mature B-cell malignancies
Sonoki, T., Harder, L., Horsman, D. E., et al. (2001) · Blood · doi:10.1182/blood.v98.9.2837 · Cited by 132
Translocations targeting CCND2, CCND3, and MYCN do occur in t(11;14)-negative mantle cell lymphomas
Włodarska, I., Dierickx, D., Vanhentenrijk, V., Roosbroeck, K. V., Pospíšilová, H., Minnei, F., Verhoef, G. E. G., Thomas, J., Vandenberghe, P., & Wolf‐Peeters, C. D. (2008) · Blood · doi:10.1182/blood-2007-10-118794 · Cited by 129
Cited by
Cheah, C. Y., Seymour, J. F., & Wang, M. L. (2016) · Journal of Clinical Oncology · doi:10.1200/jco.2015.63.5904 · Cited by 264
Navarro, A., Clot, G., Royo, C., Jares, P., Hadzidimitriou, A., Agathangelidis, A., Bikos, V., Darzentas, N., Papadaki, T., Salaverria, I., et al. (2012) · Cancer Research · doi:10.1158/0008-5472.can-12-1615 · Cited by 256
Self-citationCao, Y.-J., Zheng, Y.-H., Li, Q., Zheng, J., Ma, L.-T., Zhao, C.-J., & Li, T. (2022) · Journal of Oncology · doi:10.1155/2022/4705654 · Cited by 10
Metadata
- Authors
- Mozos, A., Royo, C., Hartmann, E., De Jong, D., Baro, C., Valera, A., Fu, K., Weisenburger, D. D., Delabie, J., Chuang, S.-S., Jaffe, E. S., Ruiz-Marcellan, C., Dave, S., Rimsza, L., Braziel, R., Gascoyne, R. D., Sole, F., Lopez-Guillermo, A., Colomer, D., Staudt, L. M., Rosenwald, A., Ott, G., Jares, P., & Campo, E.
- Venue
- Haematologica
- Published
- 2009-10-30
- Volume
- 94
- Issue
- 11
- Pages
- 1555-1562
- ISSN
- 0390-6078 (ISSN-L)
- 1592-8721
- OpenAlex
- W2147758514
- Cited by
- 398
- References
- 13
- FWCI
- 18.09
- Type
- journal article
- Language
- en
- Open access
- gold
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- Mozos, A., Royo, C., Hartmann, E., De Jong, D., Baro, C., Valera, A., Fu, K., Weisenburger, D. D., Delabie, J., Chuang, S.-S., Jaffe, E. S., Ruiz-Marcellan, C., Dave, S., Rimsza, L., Braziel, R., Gascoyne, R. D., Sole, F., Lopez-Guillermo, A., Colomer, D., . . . Campo, E. (2009). SOX11 expression is highly specific for mantle cell lymphoma and identifies the cyclin D1-negative subtype. Haematologica. https://doi.org/10.3324/haematol.2009.010264
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