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Erythropoietin administration in humans causes a marked and prolonged reduction in circulating hepcidin
Open accessAbstract
Expression of hepcidin, the key hormone governing iron transport, is reduced by anemia in a manner which appears dependent on increased bone marrow activity. The temporal associations between plasma hepcidin and other iron parameters were examined in healthy humans after erythropoietin administration and venesection. Profound hepcidin suppression appeared abruptly 24 hours after subcutaneous erythropoietin (P=0.003), and was near maximal at onset, with peak (mid-afternoon) levels reduced by 73.2%, gradually recovering over the following two weeks. Minor changes in circulating iron, soluble transferrin receptor and growth differentiation factor-15 were observed after the reduction in hepcidin. Similar but more gradual changes in these parameters were observed after reducing hematocrit by removal of 250 mL blood. These human studies confirm the importance of a rapidly responsive marrow-hepcidin axis in regulating iron supply in vivo, and suggest that this axis is regulated by factors other than circulating iron, soluble transferrin receptor or growth differentiation factor-15.
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“studies in humans receiving recombinant EPO have not yet shown a significant inverse relationship between serum hepcidin and GDF15 levels”
From Regulation of erythropoiesis by hypoxia-inducible factors (2013) · cites this paper as [222]
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Wagner, M., & Ashby, D. R. (2013) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gft330 · Cited by 12
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Hu, R., Li, G., Hu, P., Niu, H., Li, W., Jiang, S., Guan, G., Xu, Q., Liu, M., & Chen, L. (2024) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/j.jgg.2024.10.003 · Cited by 7
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Metadata
- Authors
- Ashby, D. R., Gale, D. P., Busbridge, M., Murphy, K. G., Duncan, N. D., Cairns, T. D., Taube, D. H., Bloom, S. R., Tam, F. W. K., Chapman, R., Maxwell, P. H., & Choi, P.
- Affiliations
- Hammersmith Hospital (GB)
- University College London (GB)
- Imperial College London (GB)
- Venue
- Haematologica
- Published
- 2009-10-14
- Volume
- 95
- Issue
- 3
- Pages
- 505-508
- ISSN
- 0390-6078 (ISSN-L)
- 1592-8721
- PMC
- PMC2833083
- OpenAlex
- W2034565548
- Cited by
- 191
- References
- 26
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 9 · 2023: 7 · 2022: 8 · 2021: 6 · 2020: 8 · 2019: 10 · 2018: 8 · 2017: 14 · 2016: 11 · 2015: 16 · 2014: 21 · 2013: 21 · 2012: 16
- FWCI
- 10.44
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Haematologica (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Wellcome Trust
- National Institute for Health and Care Research (NF-SI-0507-10315)
- Medical Research Council
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Health Sciences › Medicine › Hematology › Erythropoietin and Anemia Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Hemoglobin structure and function
- Keywords
- erythropoietin, hepcidin, iron metabolism, anemia, bone marrow, phlebotomy, soluble transferrin receptor, growth differentiation factor 15, hematocrit
- MeSH terms
- Adult, Bone Marrow, Erythropoietin, Humans, Injections, Subcutaneous, Iron, Male, Receptors, Transferrin, Transferrin, Antimicrobial Cationic Peptides, Growth Differentiation Factor 15, Hepcidins
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