Cited by 472Iron Metabolism and DisordersErythropoietin and Anemia TreatmentHemoglobin structure and function

Suppression of hepcidin during anemia requires erythropoietic activity

Open access
Pak, Mihwa, Lopez, Miguel A., Gabayan, Victroia, Ganz, Tomas, Rivera, Seth·2006·Blood

Abstract

Hepcidin, the principal iron regulatory hormone, regulates the absorption of iron from the diet and the mobilization of iron from stores. Previous studies indicated that hepcidin is suppressed during anemia, a response that would appropriately increase the absorption of iron and its release from stores. Indeed, in the mouse model, hepcidin-1 was suppressed after phlebotomy or erythropoietin administration but the suppression was reversed by inhibitors of erythropoiesis. The suppression of hepcidin necessary to match iron supply to erythropoietic demand thus requires increased erythropoiesis and is not directly mediated by anemia, tissue hypoxia, or erythropoietin.

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Crossref · 10.1182/blood-2006-06-028787

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Research works printed but not linked: 6

  1. Finch C. Regulators of iron balance in humans. Blood. 1994;84:1697-1702.
  2. Mosby's Drug Consult. Stat!Ref Online Electronic Medical Library (15). http://www.mosbydrugs. com. Accessed June 10, 2005.
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  5. Neumann CA, Krause DS, Carman CV, et al. Es- sential role for the peroxiredoxin Prdx1 in erythro- cyte antioxidant defence and tumour suppres- sion. Nature. 2003;424:561-565.
  6. Rund D, Rachmilewitz E. Beta-thalassemia. N Engl J Med. 2005;353:1135-1146.

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Authors
Pak, M., Lopez, M. A., Gabayan, V., Ganz, T., & Rivera, S.
Affiliations
University of California, Los Angeles (US)
Venue
Blood
Published
2006-12-01
Volume
108
Issue
12
Pages
3730-3735
ISSN
  • 0006-4971 (ISSN-L)
  • 1528-0020
OpenAlex
W1973313690
Cited by
472
References
40
Citations by year
2026: 3 · 2025: 2 · 2024: 10 · 2023: 16 · 2022: 10 · 2021: 22 · 2020: 18 · 2019: 16 · 2018: 21 · 2017: 38 · 2016: 15 · 2015: 27 · 2014: 37 · 2013: 37 · 2012: 35
FWCI
16.48
Type
journal article
Language
en
Open access
Locations
  • Blood (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (K08 DK)
  • National Institute of Diabetes and Digestive and Kidney Diseases (R01DK065029, K08 DK 07284-01)
Topics
  • Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
  • Health Sciences › Medicine › Hematology › Erythropoietin and Anemia Treatment
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Hemoglobin structure and function
Keywords
hepcidin, anemia, erythropoiesis, erythropoietin, iron regulation, iron absorption, iron mobilization, phlebotomy, hypoxia
MeSH terms
Anemia, Animals, Hypoxia, Erythropoiesis, Erythropoietin, Female, Iron, Male, Iron, Dietary, Antimicrobial Cationic Peptides, Mice, Hepcidins

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