The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Minimal residual disease prior to allogeneic hematopoietic cell transplantation in acute myeloid leukemia: a meta-analysis
Open accessAbstract
Minimal residual disease prior to allogeneic hematopoietic cell transplantation has been associated with increased risk of relapse and death in patients with acute myeloid leukemia, but detection methodologies and results vary widely. We performed a systematic review and meta-analysis evaluating the prognostic role of minimal residual disease detected by polymerase chain reaction or multiparametric flow cytometry before transplant. We identified 19 articles published between January 2005 and June 2016 and extracted hazard ratios for leukemia-free survival, overall survival, and cumulative incidences of relapse and non-relapse mortality. Pre-transplant minimal residual disease was associated with worse leukemia-free survival (hazard ratio=2.76 [1.90–4.00]), overall survival (hazard ratio=2.36 [1.73–3.22]), and cumulative incidence of relapse (hazard ratio=3.65 [2.53–5.27]), but not non-relapse mortality (hazard ratio=1.12 [0.81–1.55]). These associations held regardless of detection method, conditioning intensity, and patient age. Adverse cytogenetics was not an independent risk factor for death or relapse. There was more heterogeneity among studies using flow cytometry-based than WT1 polymerase chain reaction-based detection (I2=75.1% vs.
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Cites
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Assessing Bias in Studies of Prognostic Factors
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Cited by
Measurable Residual Disease in High-Risk Acute Myeloid Leukemia
Cluzeau, T., Lemoli, R. M., McCloskey, J., & Cooper, T. (2022) · Cancers · doi:10.3390/cancers14051278 · Cited by 13
Metadata
- Authors
- Buckley, S. A., Wood, B. L., Othus, M., Hourigan, C. S., Ustun, C., Linden, M. A., DeFor, T. E., Malagola, M., Anthias, C., Valkova, V., Kanakry, C. G., Gruhn, B., Buccisano, F., Devine, B., & Walter, R. B.
- Venue
- Haematologica
- Published
- 2017-01-25
- Volume
- 102
- Issue
- 5
- Pages
- 865-873
- ISSN
- 0390-6078 (ISSN-L)
- 1592-8721
- OpenAlex
- W2582929611
- Cited by
- 283
- References
- 28
- FWCI
- 4.71
- Type
- journal article
- Language
- en
- Open access
- gold
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- Buckley, S. A., Wood, B. L., Othus, M., Hourigan, C. S., Ustun, C., Linden, M. A., DeFor, T. E., Malagola, M., Anthias, C., Valkova, V., Kanakry, C. G., Gruhn, B., Buccisano, F., Devine, B., & Walter, R. B. (2017). Minimal residual disease prior to allogeneic hematopoietic cell transplantation in acute myeloid leukemia: a meta-analysis. Haematologica. https://doi.org/10.3324/haematol.2016.159343
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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