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Cited by 4Diabetes Treatment and ManagementDiabetes Management and ResearchDiabetes, Cardiovascular Risks, and Lipoproteins

Comparative efficacy of insulin, biguanides and sulfonylureas in the glycemic control of newly diagnosed diabetes mellitus patients in Rajshahi, Bangladesh

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Zaman, Md Saif Zaman, Hassan, Parvez Hassan, Islam, S M Shahinul Islam, Ullah, Md Anayet Ullah, Rabbani, Md Golam Rabbani·2023·Journal of Bio-Science
DOI 10.3329/jbs.v31i1.69533
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Abstract

The goal of the present study was to examine how well three distinct kinds of anti-diabetic drugs- insulin, biguanides and sulfonylureas performed in Bangladeshi patients who had recently been diagnosed with diabetes mellitus. This was an observational study and carried out on 102 patients admitted in different hospitals in Rajshahi, Bangladesh during the study period. Majority (32.02%) respondents belonged to 51-60 years age group, followed by 41-50 years and the least >60 years age group viz. 7.19%. Female preponderance was noticed in the study population where 59.80% were females; whereas 40.20% males. Results of distribution of respondents based on residence and class of anti-diabetic medication use showed in insulin receiving group 66.67% were urban people and 33.33% were rural resident; biguanides receiving groups 64.71% were urban resident and 35.29% were rural resident; sulfonylureas receiving groups 58.82% were urban resident and 41.18% were rural residents. Data on participant’s lifestyle and smoking habit showed lifestyle of 65.70% patients were sedentary and 34.30% were active and according to smoking habit of the patients 14% were smokers while 86% were non-smokers. Family history of DM among the patients showed 17% had familial history and 83% did not have. Data showed that the patients taken insulin, biguanides and sulfonylurea as with BMI were mostly in 18.50 - 24.99 with p-value 0.621. Although no statistically significant difference was noticed among the groups regarding treatment response of three drugs (p = 0.252, 0.284, 0.675 for HbA1c, FBS and PPBS respectively) after 3 months follow-up of medication use and (p = 0.284, 0.323, 0.817 for HbA1c, FBS and PPBS respectively) after 6 months follow-up. However, p-value was not significant but insulin receiving patients had relatively better treatment response than biguanide receiving group than sulfonylurea receiving group at 3rd and 6th month. In insulin receiving group 90.19 % had desired glycemic control. In biguanide receiving group 76.47 % had desired glycemic control. In sulfonylurea receiving group 84.31 % had desired glycemic control. So it appears that insulin provides the best glycemic control followed by sulfonylurea and the biguanides are relativity less potent in glycemic control of newly diagnosed patients in our study area. In this study, the sample size was quite small, which may not represent the whole population and the research used purposeful sampling, which may have skewed the results. J. Bio-Sci. 31(1): 39-49, 2023

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  • Sulfonylureas act by directly obstructing ATP-sensitive K+ channels on islet cells, which increases the generation of insulin.

    “Their mechanism action is by directly obstructing ATP-sensitive K+ channels on islet cells, which increases the generation of insulin.”

    From A critical review on diabetes mellitus type 1 and type 2 management approaches: from lifestyle modification to current and novel targets and therapeutic agents. (2024) · cites this paper as [59]

    The Introduction (page not provided) says sulfonylureas promote insulin release from pancreatic beta cells. It does not describe obstruction of ATP-sensitive K+ channels or increased insulin generation; release is not the same as generation. (LLM, conf=0.88)

    Experimental — accuracy not yet measured

  • Sulfonylureas' primary acute side effect is a higher incidence of hypoglycemia, particularly in elderly patients with impaired renal function, hepatic dysfunction, poor oral intake, calorie restriction, alcohol abuse, and other disorders.

    “Sulfonylureas’ primary acute side effect, is a higher incidence of hypoglycemia, particularly in elderly patients with impaired renal function, hepatic dysfunction, poor oral intake, calorie restriction, alcohol abuse, and other disorders (56, 59).”

    From A critical review on diabetes mellitus type 1 and type 2 management approaches: from lifestyle modification to current and novel targets and therapeutic agents. (2024) · cites this paper as [59]

    The Introduction (page unavailable) calls hypoglycemia the most common serious side effect of sulfonylureas, and the Conclusion says they can cause severe hypoglycemia. The paper does not identify elderly patients or those with renal impairment, hepatic dysfunction, poor intake, calorie restriction, or alcohol abuse as being at particular risk; a search for those factors found no supporting passage. (LLM, conf=0.88)

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Research works printed but not linked: 24

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Authors
Zaman, M. S. Z., Hassan, P. H., Islam, S. M. S. I., Ullah, M. A. U., & Rabbani, M. G. R.
Affiliations
  • University of Rajshahi (BD)
  • Rajshahi Medical College (BD)
ORCID
Venue
Journal of Bio-Science
Publisher
Bangladesh Academy of Sciences
Published
2023-11-05
Volume
31
Issue
1
Pages
39-49
ISSN
  • 1023-8654 (ISSN-L)
  • 2408-8595
DOI
10.3329/jbs.v31i1.69533
OpenAlex
W4388383247
Cited by
4
References
1
Citations by year
2026: 1 · 2025: 1 · 2024: 2
FWCI
0.82
Type
journal article
Language
en
Open access
Licence
Locations
Journal of Bio-Science (publishedVersion, cc-by)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords
insulin, biguanides, sulfonylureas, newly diagnosed diabetes, glycemic control, HbA1c, fasting blood glucose, postprandial blood glucose, treatment response, urban-rural distribution, sedentary lifestyle, smoking, family history of diabetes, body mass index, Bangladesh

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