Health Related Quality of Life in Common Variable Immunodeficiency
Open accessAbstract
PURPOSE: To quantify the health related quality of life in primary immunodeficiency patients. MATERIALS AND METHODS: We used generic health status and general psychological health questionnaires to determine the range of issues that needed to be considered in examining the burden of common variable immunodeficiency (CVID). RESULTS: The health status of patients with CVID was lower than that observed in normal subjects. Overall, Role-Physical and General Health scales correlated with a poorer clinical status. Surprisingly, the duration of disease did not influence health status. Being female, older, General Health Questionnaire-positive and alexithymic proved to be major risk factors associated with a poor health status. Patients with chronic lung disease and chronic diarrhea had the lowest values on the Medical Outcome Study, Short Form SF-36 (SF-36) scales. Disease severity perception was associated with the General Health Questionnaire and alexithymia status. Limitations in daily activities as a result of lower physical health were the major problems facing common variable immunodeficiency patients. CONCLUSION: Our data underlined the importance of conducting a periodical health related quality of life assessment on patients with primary antibody deficiencies and, moreover, stressed the necessity of providing psychological support to at risk patients.
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Other research and patient groups have highlighted the need for provision of psychological therapy as part of standard care for people with PAD.
“Other research and patient groups have also highlighted the need for the provision of psychological therapy as part of the standard care package for people with PAD 14-17 .”
From Investigating the Effectiveness, Acceptability and Impact on Healthcare Usage of Providing a Cognitive-Behavioural Based Psychological Therapy Service for Patients with Primary Antibody Deficiency (2018) · cites this paper as [16]
The Discussion recommends lifelong psychological support for at-risk patients with primary antibody deficiencies. It does not specifically call for psychological therapy as part of a standard care package for all people with PAD. (LLM, conf=0.86)
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- Authors
- Quinti, I., Di Pietro, C., Martini, H., Pesce, A. M., Lombardi, F., Baumghartner, M., Colantuono, S., Milito, C., & Tabolli, S.
- Affiliations
- Sapienza University of Rome (IT)
- Health Services Research Unit, Istituto Dermopatico Dell'Immacolata IDI-IRCCS, Rome, Italy.
- Department of Molecular Medicine, Sapienza University of Rome and Fondazione Eleonora Lorillard Spencer Cenci, Rome, Italy.
- Istituto Dermopatico dell'Immacolata (IT)
- Corresponding author
- Tabolli, Stefano
- Venue
- Yonsei Medical Journal
- Published
- 2012
- Volume
- 53
- Issue
- 3
- Pages
- 603
- ISSN
- 0513-5796 (ISSN-L)
- 1976-2437
- PMC
- PMC3343431
- OpenAlex
- W1976889032
- Cited by
- 52
- References
- 36
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 4 · 2023: 1 · 2022: 7 · 2021: 5 · 2020: 5 · 2019: 5 · 2018: 7 · 2017: 7 · 2016: 4 · 2015: 2 · 2014: 2 · 2012: 1
- FWCI
- 0.70
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Yonsei Medical Journal (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immunodeficiency and Autoimmune Disorders
- Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Health Systems, Economic Evaluations, Quality of Life
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cystic Fibrosis Research Advances
- Keywords
- common variable immunodeficiency, health-related quality of life, primary immunodeficiency, primary antibody deficiency, alexithymia, chronic lung disease, chronic diarrhea, disease severity perception, psychological support, SF-36, General Health Questionnaire
- MeSH terms
- Chronic Disease, Female, Health Status, Humans, Male, Quality of Life, Surveys and Questionnaires, Common Variable Immunodeficiency
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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