Life style change and reverse cholesterol transport in obese women
Open accessAbstract
HDL cholesterol resp. apolipoprotein A1 concentrations are tools to estimate individual CVD risk, although only a part of HDL particles participate in reverse cholesterol transport (RCT). This discrepancy was analyzed in life style change based on increase of physical activity and dietary counseling. Efflux of cholesterol from pre-labeled macrophages to plasma acceptors of tested individuals was used as an RCT measure. Changes of lipoprotein parameters, glucose, fasting insulin concentrations and RCT were analyzed in 15 obese women after 9-week intervention consisted of 5 sessions of increased physical activity per week. Controlled increase in physical activity for 9 weeks induced a decrease of body weight averaging 9 kg (ranged from 2.3 to 15.5 kg). The intervention leads to significant decreases of triglycerides, apoprotein A1 and apoprotein B concentration, whereas total cholesterol, LDL cholesterol and HDL cholesterol did not change significantly. The increase of RCT was not significant, but there was highly significant negative correlation between individual decrease of body weight and an increase of RCT. Significant increase of RCT was found in 13 persons with a weight reduction more than 3.5 kg. Substantial weight loss is necessary to increase RCT.
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Králová Lesná et al. found that exercise could increase cholesterol efflux by 1.8% after 9 weeks of training.
“Králová Lesná et al. [34] found that exercise could increase cholesterol efflux by 1.8% after 9 weeks training.”
From Effects of aerobic exercise on lipids and lipoproteins (2017) · cites this paper as [34]
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Effects of aerobic exercise on lipids and lipoproteins
Wang, Y., & Xu, D. (2017) · Lipids in Health and Disease · doi:10.1186/s12944-017-0515-5 · Cited by 436 · see citing works
- Authors
- Králová Lesná, I., Suchánek, P., Kovář, J., & Poledne, R.
- Affiliations
- Institute of Clinical and Experimental Medicine (CZ)
- Czech Academy of Sciences (CZ)
- ORCID
- Venue
- Physiological Research
- Published
- 2009
- Volume
- 58 Suppl 1
- Pages
- S33-S38
- ISSN
- 0862-8408 (ISSN-L)
- 1802-9973
- OpenAlex
- W2405949054
- Cited by
- 19
- References
- 19
- Citations by year
- 2025: 2 · 2020: 1 · 2018: 3 · 2017: 3 · 2016: 2 · 2015: 2 · 2014: 1 · 2013: 1 · 2012: 1
- FWCI
- 1.35
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc
- Locations
- Physiological Research (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- reverse cholesterol transport, HDL cholesterol, apolipoprotein A-I, apolipoprotein B, obesity, obese women, physical activity, weight loss, nutrition counseling, macrophage cholesterol efflux, cardiovascular risk, triglycerides, fasting insulin
- MeSH terms
- Adult, Apolipoproteins B, Biological Transport, Cholesterol, Combined Modality Therapy, Counseling, Diet, Female, Humans, Macrophages, Obesity, Time Factors, Triglycerides, Biomarkers, Weight Loss, Exercise, Apolipoprotein A-I, Treatment Outcome, Risk Reduction Behavior, Waist Circumference
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