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Cited by 16Ion channel regulation and functionNeuroscience and Neuropharmacology ResearchCardiac electrophysiology and arrhythmias

Profound Alterations in the Intrinsic Excitability of Cerebellar Purkinje Neurons Following Neurotoxin 3-Acetylpyridine (3-AP)-Induced Ataxia in Rat: New Insights Into the Role of Small Conductance K+ Channels

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KAFFASHIAN, M., SHABANI, M., GOUDARZI, I., BEHZADI, G., ZALI, A., JANAHMADI, M.·2011·Physiological Research
DOI 10.33549/physiolres.932032
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Abstract

Alterations in the intrinsic properties of Purkinje cells (PCs) may contribute to the abnormal motor performance observed in ataxic rats. To investigate whether such changes in the intrinsic neuronal excitability could be attributed to the role of Ca2+-activated K+ channels (KCa), whole cell current clamp recordings were made from PCs in cerebellar slices of control and ataxic rats. 3-AP induced profound alterations in the intrinsic properties of PCs, as evidenced by a significant increase in both the membrane input resistance and the initial discharge frequency, along with the disruption of the firing regularity. In control PCs, the blockade of small conductance KCa channels by UCL1684 resulted in a significant increase in the membrane input resistance, action potential (AP) half-width, time to peak of the AP and initial discharge frequency. SK channel blockade also significantly decreased the neuronal discharge regularity, the peak amplitude of the AP, the amplitude of the after- hyperpolarization and the spike frequency adaptation ratio. In contrast, in ataxic rats, both the firing regularity and the initial firing frequency were significantly increased by the blockade of SK channels. In conclusion, ataxia may arise from alterations in the functional contribution of SK channels, to the intrinsic properties of PCs.

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  • Irregular neuronal firing may be caused by intrinsic cellular mechanisms through the stochastic gating of ion channels in the membrane, such as potassium ion channels.

    “Second, irregular neuronal firing may be caused by intrinsic cellular mechanisms through the stochastic gating of ion channels in the membrane, such as potassium ion channels [70–73].”

    From Chronic unpredictable stress induces depression-related behaviors by suppressing AgRP neuron activity (2021) · cites this paper as [70]

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Authors
KAFFASHIAN, M., SHABANI, M., GOUDARZI, I., BEHZADI, G., ZALI, A., & JANAHMADI, M.
Affiliations
  • Medical University of Ilam (IR)
  • Kerman University of Medical Sciences (IR)
  • Damghan University (IR)
  • Shahid Beheshti University of Medical Sciences (IR)
Corresponding author
JANAHMADI, M.
ORCID
Venue
Physiological Research
Publisher
Institute of Physiology of the Czech Academy of Sciences
Published
2011-04-16
Volume
60
Issue
2
Pages
355-365
ISSN
  • 0862-8408 (ISSN-L)
  • 1802-9973
DOI
10.33549/physiolres.932032
OpenAlex
W2113734421
Cited by
16
References
61
Citations by year
2025: 1 · 2024: 1 · 2023: 2 · 2021: 3 · 2020: 1 · 2016: 3 · 2014: 2 · 2013: 2 · 2012: 1
FWCI
0.65
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Physiological Research (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Research Repository Portal (Ilam University of Medical Sciences) (submittedVersion)
Funders
  • National Science Foundation
  • Iran National Science Foundation
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
Keywords
Purkinje cells, cerebellum, 3-acetylpyridine, small conductance calcium-activated potassium channels, neuronal excitability, membrane input resistance, spike frequency adaptation, afterhyperpolarization, action potential
MeSH terms
Action Potentials, Alkanes, Animals, Cerebellar Ataxia, Neurotoxins, Purkinje Cells, Pyridines, Quinolinium Compounds, Patch-Clamp Techniques, Rats, Small-Conductance Calcium-Activated Potassium Channels

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