Cardiovascular regulation during body unweighting by lower body positive pressure
Abstract
BACKGROUND: We hypothesized that human cardiovascular responses to standing in reduced gravity environments, as on the Moon or Mars, could be modeled using a lower body positive pressure (LBPP) chamber. METHODS: Heart rate, blood pressure, body segment fluid shifts, ECG, indexes of sympathetic, parasympathetic balance, and baroreflex control of the heart and periphery plus echocardiographic measures of cardiac function were recorded from seven men and seven women supine and standing at 100% (Earth), 40% (-Mars), and 20% (-Moon) bodyweights (BW). RESULTS: The fluid shifted from the chest was greater when standing at 100% BW than at 20% and 40% BW, while fluid pooled in the abdomen was similar at all BWs. Compared to moving from supine to standing at 100% BW, moving to 20% and 40% BW resulted in smaller decreases in stroke volume and pulse pressure, smaller increases in heart rate and smaller decreases in parasympathetic control of heart rate, baroreflex slope, numbers of blood pressure ramps, and much reduced indexes of sympathetic drive to the heart and periphery. However, peripheral vascular resistance, systolic pressure, and baroreflex effectiveness were elevated during 20% and 40% BW, compared to supine and standing at 100% BW. DISCUSSION: Standing at reduced bodyweight suppressed indexes of sympathetic control of heart rate and peripheral vasomotion. Regulatory responses indicated a combination of arterial and cardiopulmonary baroreflex control: mean heart rate, vasomotion, and baroreflex sensitivity appeared to be more under cardiopulmonary control while baroreflex effectiveness appeared to be driven more by the arterial baroreflex.
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Evans et al. (2013) found different significant results in diastolic blood pressure for males and females.
“For example Evans et al. (2013) found different significant results in diastolic blood pressure for males and females;”
From Human Biomechanical and Cardiopulmonary Responses to Partial Gravity – A Systematic Review (2017) · cites this paper as Evans et al. (2013)
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Human Biomechanical and Cardiopulmonary Responses to Partial Gravity – A Systematic Review
Richter, C., Braunstein, B., Winnard, A., Nasser, M., & Weber, T. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00583 · Cited by 75 · see citing works
“Some studies reported increasing values (Cutuk et al., 2006; Evans et al., 2013; Kostas et al., 2014) and some other studies reported decreasing values (Cardus, 1996; Chang et al., 1996; Aerts et al., 2012; Kostas et al., 2014; Widjaja et al., 2015) or unchanged values (Schlabs et al., 2013) in…”
BackgroundResultBody Size Predicts Cardiac and Vascular Resistance Effects on Men's and Women's Blood Pressure
Evans, J. M., Wang, S., Greb, C., et al. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00561 · Cited by 34 · see citing works
“These original studies were designed to document cardiovascular effects of lower body positive pressure (LBPP) applied to subjects in a standing position (Evans et al., 2013; Kostas et al., 2014; Zhang et al., 2014).”
BackgroundSelf-citationCardiovascular and cardiorespiratory phase synchronization in normovolemic and hypovolemic humans
Zhang, Q., Patwardhan, A. R., Knapp, C. F., et al. (2014) · European Journal of Applied Physiology · doi:10.1007/s00421-014-3017-4 · Cited by 26 · see citing works
“Effects of several interventions to orthostatic intolerance, especially in the field of space medicine, such as lower body compression (Zhang et al. 2014; Evans et al. 2013) and artificial gravity (Evans et al. 2004), have been analyzed using conventional methods.”
Self-citationCardiovascular autonomic adaptation in lunar and martian gravity during parabolic flight
Widjaja, D., Vandeput, S., Van Huffel, S., & Aubert, A. E. (2015) · European Journal of Applied Physiology · doi:10.1007/s00421-015-3118-8 · Cited by 24 · see citing works
“In recent studies, Moon and Mars gravity fields were simulated using lower body positive pressure (Evans et al. 2013; Kostas et al. 2014).”
MethodDiaz‐Artiles, A., Tichell, P. N., & Perez, F. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00720 · Cited by 18 · see citing works
“Other studies conducted simulations on Earth that included the use of Lower Body Positive Pressure (LBPP) (Cutuk, 2006; Evans et al., 2013; Schlabs et al., 2013), parabolic flights (Pletser, 2004; Pletser et al., 2012; Widjaja et al., 2015), and head-down tilt (HDT) and head-up-tilt (HUT) paradigms (Lathers et al., 19…”
MethodSimulations of Gravitational Stress on Normovolemic and Hypovolemic Men and Women
Zhang, Q., Knapp, C. F., Stenger, M. B., Patwardhan, A. R., Elayi, C. S., Wang, S., Kostas, V. I., & Evans, J. M. (2014) · Aviation Space and Environmental Medicine · doi:10.3357/asem.3828.2014 · Cited by 9 · see citing works
“In the normovolemic condition, application of LBPP resulted in non-significant increases of standing SBP, DBP and MAP, which are consistent with our previous study (6) and others (3).”
BackgroundResultInfluentialSelf-citationAvadhani, S. A., Ihsan, M., Nunez, A., Kamran, H., Singh, S. B., Hasan, Z., Salciccioli, L. F., Kral, J. G., Godwin, E. M., & Lazar, J. (2018) · Dose-Response · doi:10.1177/1559325818811543 · Cited by 3 · see citing works
“Evans et al found that standing at reduced bodyweight suppressed indexes of sympathetic control of heart rate.(20) Less prominent LBPP induced HR lowering observed in the HF group was likely related to depressed baroreceptor function, which is well known to accompany HF.”
BackgroundResult
- Authors
- Evans, J. M., Mohney, L., Wang, S., Moore, R. K., Elayi, S.-C., Stenger, M. B., Moore, F. B., & Knapp, C. F.
- Affiliations
- University of Kentucky (US)
- Venue
- Aviation Space and Environmental Medicine
- Publisher
- Aerospace Medical Association
- Published
- 2013-11-01
- Volume
- 84
- Issue
- 11
- Pages
- 1140-1146
- ISSN
- 0001-9402 (ISSN-L)
- 0095-6562
- OpenAlex
- W2329455131
- Cited by
- 9
- References
- 0
- Citations by year
- 2019: 1 · 2018: 1 · 2017: 3 · 2015: 1 · 2014: 3
- FWCI
- 0.93
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Aviation Space and Environmental Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Johnson Space Center
- Office of Experimental Program to Stimulate Competitive Research
- Topics
- Health Sciences › Medicine › Physiology › Spaceflight effects on biology
- Health Sciences › Medicine › Surgery › Cardiovascular Syncope and Autonomic Disorders
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Keywords
- lower body positive pressure, reduced gravity, cardiovascular regulation, standing, fluid shifts, baroreflex sensitivity, sympathetic nervous system, parasympathetic modulation, heart rate, stroke volume, systemic vascular resistance, cardiopulmonary baroreflex, arterial baroreflex, spaceflight physiology, Moon
- MeSH terms
- Blood Pressure, Cardiovascular System, Female, Heart Rate, Humans, Male, Space Flight, Stroke Volume, Vascular Resistance, Baroreflex, Hypogravity
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