Fucoidan-mediated anisotropic calcium carbonate nanorods of pH-responsive drug release for antitumor therapy
Open accessAbstract
The shape of nanoparticles can determine their physical properties and then greatly impact the physiological reactions on cells or tissues during treatment. Traditionally spherical nanoparticles are more widely applied in biomedicine but are not necessarily the best. The superiority of anisotropic nanoparticles has been realized in recent years. The synthesis of the distinct-shaped metal/metal oxide nanoparticles is easily controlled. However, their biotoxicity is still up for debate. Hence, we designed CaCO 3 nanorods for drug delivery prepared at mild condition by polysaccharide-regulated biomineralization in the presence of fucoidan with sulfate groups. The CaCO 3 nanorods with a pH sensitivity–loaded antitumor drug mitoxantrone hydrochloride (MTO) showed excellent antitumor efficacy for the HeLa cells and MCF-7 cells in vitro . We believe that anisotropic nanoparticles will bring forth an emblematic shift in nanotechnology for application in biomedicine.
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Due to its large number of negatively charged sulfonic acidic groups, fucoidan is considered to be pH sensitive.
“Due to its large number of negatively charged sulfonic acidic groups, fucoidan is considered to be pH sensitive (Wang et al., 2022; Haggag et al., 2023).”
From pH stimuli-responsive hydrogels from non-cellulosic biopolymers for drug delivery. (2023) · cites this paper as Wang et al., 2022
The Results and Discussion (§3.1; page unavailable) describe fucoidan’s sulfuric ester groups and their electrostatic attraction to Ca²⁺. But the Introduction and §3.2 attribute pH sensitivity to acid-triggered decomposition of the calcium carbonate nanorods, not to fucoidan or its sulfate groups. The cited paper therefore supports the group-related part of the claim, but not its proposed explanation of fucoidan’s pH sensitivity. (LLM, conf=0.86)
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- Authors
- Wang, P., Tong, F., Luo, J., Li, Z., Wei, J., & Liu, Y.
- Affiliations
- Nanchang University (CN)
- Huaqiao University (CN)
- Corresponding author
- Wei, Junchao
- Liu, Yuangang
- Venue
- Frontiers in Bioengineering and Biotechnology
- Publisher
- Frontiers Media SA
- Published
- 2022-04-13
- Volume
- 10
- Pages
- 845821-845821
- ISSN
- 2296-4185 (ISSN-L)
- PMC
- PMC9043484
- OpenAlex
- W4223896611
- Cited by
- 18
- References
- 51
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 7 · 2023: 5
- FWCI
- 1.00
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Bioengineering and Biotechnology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China (52163016 32171337 82060198)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Calcium Carbonate Crystallization and Inhibition
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Keywords
- fucoidan, anisotropic nanoparticles, pH-responsive drug release, anticancer drug delivery, HeLa cells, MCF-7 cells, biotoxicity
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