MTOR: a pharmacologic target for autophagy regulation
Open accessAbstract
mTOR, a serine/threonine kinase, is a master regulator of cellular metabolism. mTOR regulates cell growth and proliferation in response to a wide range of cues, and its signaling pathway is deregulated in many human diseases. mTOR also plays a crucial role in regulating autophagy. This Review provides an overview of the mTOR signaling pathway, the mechanisms of mTOR in autophagy regulation, and the clinical implications of mTOR inhibitors in disease treatment.
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A family of molecules that are the mechanistic target of the rapamycin (mTOR) complex has been attributed a major role in the biology of cell metabolism, growth, longevity, and even preterm birth.
“A family of molecules that are the mechanistic target of the rapamycin (mTOR) complex has been attributed a major role in the biology of cell metabolism, growth, longevity, and even preterm birth(230–236).”
From Metformin, the Aspirin of the 21st Century: Its Role in Gestational Diabetes Mellitus, Prevention of Preeclampsia and Cancer, and the Promotion of Longevity (2017) · cites this paper as [233]
Rapamycin can prolong the life cycle of many species as diverse as worms and mice, and its signaling system has been implicated as the master regulator of cellular growth and metabolism.
“Rapamycin can also prolong the life cycle of many species as diverse as worms and mice, and its signaling system has been implicated as the master regulator of cellular growth and metabolism.”
From Metformin, the Aspirin of the 21st Century: Its Role in Gestational Diabetes Mellitus, Prevention of Preeclampsia and Cancer, and the Promotion of Longevity (2017) · cites this paper as [233]
Torin 1 showed a similar capacity to reduce iron accumulation.
“Torin 1, another inhibitor of mTOR with a different mode of action to rapamycin [70], showed a similar capacity to reduce iron accumulation (Fig. S4C).”
From Iron accumulation in senescent cells is coupled with impaired ferritinophagy and inhibition of ferroptosis (2018) · cites this paper as [70]
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Flagged first, then by citations
Research works printed but not linked: 3
- Reference information: J Clin Invest. 2015;125(1):25-32. doi:10.1172/JCI73939.
- Wander SA, Hennessy BT, Slingerland JM. Nex- t-generation mTOR inhibitors in clinical oncol- ogy: how pathway complexity informs therapeu- tic strategy. J Clin Invest. 2011;121(4):1231-1241.
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- Authors
- Kim, Y. C., & Guan, K.-L.
- Corresponding author
- Guan, Kun-Liang
- Venue
- Journal of Clinical Investigation
- Published
- 2015-01-02
- Volume
- 125
- Issue
- 1
- Pages
- 25-32
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC4382265
- OpenAlex
- W1979783084
- Cited by
- 2,126
- References
- 122
- Citations by year
- 2026: 157 · 2025: 250 · 2024: 286 · 2023: 269 · 2022: 243 · 2021: 203 · 2020: 214 · 2019: 155 · 2018: 131 · 2017: 97 · 2016: 91 · 2015: 27 · 2013: 1
- FWCI
- 11.06
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institutes of Health
- University of California, San Diego
- National Cancer Institute (R01CA108941, CA18941)
- National Institute of General Medical Sciences (GM-51586, R01GM051586)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- mTOR, autophagy regulation, mTOR signaling, mTOR inhibitors, cellular metabolism, cell growth and proliferation, serine/threonine kinase
- MeSH terms
- Animals, Autophagy, Humans, Metformin, Sirolimus, TOR Serine-Threonine Kinases
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