The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Sepsis: Inflammation Is a Necessary Evil
Open accessAbstract
Sepsis is one of the leading causes of deaths world-wide and yet there are no therapies available other than ICU treatment. The patient outcome is determined by a complex interplay between the pro and anti-inflammatory responses of the body i.e., a homeostatic balance between these two competing events to be achieved for the patient's recovery. The initial attempts on drug development mainly focused on controlling inflammation, however, without any tangible outcome. This was despite most deaths occurring during the immune paralysis stage of this biphasic disease. Recently, the focus has been shifting to understand immune paralysis (caused by apoptosis and by anti-inflammatory cytokines) to develop therapeutic drugs. In this review we put forth an argument for a proper understanding of the molecular basis of inflammation as well as apoptosis for developing an effective therapy.
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Cites
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Cited by
Gan, B. H., Gaynord, J., Rowe, S. M., Deingruber, T., & Spring, D. R. (2021) · Chemical Society Reviews · doi:10.1039/d0cs00729c · Cited by 511
A flexible multiplexed immunosensor for point-of-care in situ wound monitoring
Gao, Y., Nguyen, D. T., Yeo, T., Lim, S. B., Tan, W. X., Madden, L. E., Jin, L., Long, J. Y. K., Aloweni, F. A. B., Liew, Y. J. A., et al. (2021) · Science Advances · doi:10.1126/sciadv.abg9614 · Cited by 283
Inflammation and Cell Death of the Innate and Adaptive Immune System during Sepsis
Nedeva, C. (2021) · Biomolecules · doi:10.3390/biom11071011 · Cited by 265
Self-citationSepsis-Associated Encephalopathy: from Pathophysiology to Progress in Experimental Studies
Catarina, A. V., Branchini, G., Bettoni, L., De Oliveira, J. R., & Nunes, F. B. (2021) · Molecular Neurobiology · doi:10.1007/s12035-021-02303-2 · Cited by 155
Diorio, C., Shaw, P. A., Pequignot, E., Orlenko, A., Chen, F., Aplenc, R., Barrett, D. M., Bassiri, H., Behrens, E., DiNofia, A. M., et al. (2020) · Blood Advances · doi:10.1182/bloodadvances.2020002592 · Cited by 61
Metadata
- Authors
- Nedeva, C., Menassa, J., & Puthalakath, H.
- Venue
- Frontiers in Cell and Developmental Biology
- Publisher
- Frontiers Media SA
- Published
- 2019-06-20
- Volume
- 7
- Pages
- 108-108
- ISSN
- 2296-634X (ISSN-L)
- OpenAlex
- W2952073233
- Cited by
- 301
- References
- 16
- FWCI
- 20.04
- Type
- journal article
- Language
- en
- Open access
- gold
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- Nedeva, C., Menassa, J., & Puthalakath, H. (2019). Sepsis: Inflammation Is a Necessary Evil. Frontiers in Cell and Developmental Biology. https://doi.org/10.3389/fcell.2019.00108
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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