The Senolytic Drug Navitoclax (ABT-263) Causes Trabecular Bone Loss and Impaired Osteoprogenitor Function in Aged Mice

Sharma, Anuj K., Roberts, Rachel L., Benson, Reginald D., Pierce, Jessica L., Yu, Kanglun, Hamrick, Mark W., McGee-Lawrence, Meghan E.·2020·Frontiers in Cell and Developmental Biology

Cited by (130)

Items 101–130 of 130

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  3. DNA damage response & senescence-associated secretory phenotype pathway: Emerging targets for anti-aging
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  5. Aging‐Derived Alterations in Genomic, Immune, and Metabolic Networks: Implications for Cancer Development and Therapy
    Qi Wang, Xue Sun, Xinhao Han, Xingda Zhang, Wenzheng Wang, Hongbin Wang, He Ren, Lina Gu · 2026 · MedComm – Oncology
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  7. Dual-targeting Bcl-2-mediated apoptosis and synergistic pathways: Combinatorial strategies to overcome therapeutic resistance in cancer
    Jiongjia Cheng, Haiying Wang, Yuchi Zhang, Guangxiang Liu · 2026 · Biochemical Pharmacology
  8. Slowing intervertebral disc aging in mice through long-term systemic treatment with the senolytic BCL-2/BCL-xL proteolysis targeting chimera (PROTAC) 753b
    Peter Geoffrey Alexander, Bowen Yan, Karen L. Clark, Qing D. Dong, D Wang, Yang Yang, Ting Zhang, Peiyi Zhang, Guangrong Zheng, Paul D. Robbins et al. · 2026 · Aging
  9. Interventional Strategies to Delay Aging-Related Dysfunctions of the Musculoskeletal System
    Naomasa Fukase, Ingrid Kvello Stake, Yoichi Murata, William S. Hambright, Sudheer K. Ravuri, Marc J. Philippon, Johnny Huard · 2021 · IntechOpen eBooks
  10. A geroscience approach for osteosarcopenia: Autophagy and senescence as therapeutic targets
    Natanael Perez Cordero, Patricia Veronica Schoenlein, Sadanand Fulzele, William Hill · 2022 · Elsevier eBooks
  11. Stem cells, fitness, and aging
    Kristina Viktorovna Kitaeva, Andrey Pavlovich Kiyasov, Albert Anatolyevich Rizvanov, Catrin Sian Rutland, Valeriya V. Solovyeva · 2022 · Elsevier eBooks
  12. Epigenetic Signatures of Aging: A Comprehensive Study of Biomarker Discovery
    Min Seob Lee, Hyukjung Kwon, Yonjung Kim, Na Young Min, So Young Lee, Isaac Kise Lee · 2023 · Advances in Aging Research
  13. Mild Uncoupling of Mitochondria Synergistically Enhances Senolytic Specificity and Sensitivity of Bh3 Mimetics
    Edward Fielder, Abbas Ishaq, Evon Low, Joseph Laws, Aisha Calista, Jemma Castle, Thomas von Zglinicki, Satomi Miwa · 2023 · SSRN Electronic Journal
  14. Clearance of senescent cells with ABT-263 improves biological functions of synovial mesenchymal stem cells from osteoarthritis patients
    Kentaro Endo, Yugo Miura, Keiichiro Komori, Ichiro Sekiya · 2022 · Research Square
  15. Preclinical evaluation of senescence-based strategies to improve cancer therapy
    Alejandra Estepa‐Fernández · 2022
  16. Therapy induced tumor cell senescence: mechanisms and ways to overcome
    Maria A. Zamkova, Персиянцева Надежда Александровна, Victor Vyacheslavovich Tatarskiy, Alexander Albertovich Shtil · 2023 · Biochemistry (Moscow)
  17. Aktuelle und zukünftige pharmakologische Therapieoptionen zur Behandlung der Osteoporose und deren Wirkmechanismen – ein Überblick
    Ines Fößl, Barbara Maria Obermayer-Pietsch · 2024 · Osteologie/Osteology
  18. Senescence And The Senescence Associated Secretory Phenotype In Salivary Hypofunction
    Quetsia Jean-Baptiste · 2024
  19. Stem cell-based strategies in osteoporosis: Pathophysiological insights and therapeutic perspectives
    Chao Xu · 2025 · New cell
  20. Senolytic Therapy as a Preventive Strategy for Low Back Pain
    Saber Ghazizadeh Darband, Hosni Cherif, Matthew Mannarino, Juiena Sagir, Magali Millecamps, Jean Albert Ouellet, Laura S. Stone, Lisbet Haglund · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  21. Autofluorescence and cell size-based sorting eliminates senescent cells in synovial mesenchymal stem cells from patients with osteoarthritis
    Kurea Sakuma, Kentaro Endo, Nobutake Ozeki, Hideyuki Koga, Ichiro Sekiya · 2026 · Tissue and Cell
  22. Exercise, Cellular Senescence, and Cancer: Novel Perspectives on Functional Aging Through Block Strength Training in Older Adults—A Narrative Review
    Rodrigo L. Castillo, Emilio Jofré‐Saldía, Daniela Cáceres-Vergara, Georgina M. Renard, Esteban G. Figueroa · 2026 · Biomedicines
  23. Delivery timing determines senomorphic efficacy: delayed local ruxolitinib restores macrophage polarization and rescues age-impaired bone repair
    Yamin Liu, Erin M. O’Brien, Christy Lottinger, Govindaraj Perumal, Kara L. Spiller, Liisa T. Kuhn · 2026 · Research Square
  24. Senolytic Therapy as a Preventive Strategy for Spine Degeneration and Pain
    Saber Ghazizadeh Darband, Hosni Cherif, Matthew Mannarino, Juiena Sagir, Magali Millecamps, Jean Albert Ouellet, Laura S. Stone, Lisbet Haglund · 2026 · Advanced Science
  25. SENOLÍTICOS E A MODULAÇÃO DA SENESCÊNCIA CELULAR: IMPACTOS POTENCIAIS NA PREVENÇÃO DE DOENÇAS CARDIOVASCULARES E METABÓLICAS
    Rosiclerk Ottilo Cavassani Neto, Irlane Silva Veras, Leonardo Lucio Martins Teixeira, Gotardo Duarte Dumaresq Filho, Fernando Malachias de Andrade Bergamo, Chrystianne Ferreira da Silva Braz Cunha, Paulo Sérgio Silva Rocha, Clara Luquetti Paiva, BIANCA DA SILVA AMARANTE GOMES, Filipe Otavio Pimentel Gaspar · 2026 · RECIMA21 - Revista Científica Multidisciplinar
  26. Progress on novel compounds for the treatment of bone metabolism-related disorders: focus on osteoporosis and beyond
    Yeqiong Song, Ruixing Zhang, Xinyue Zhang, Jingkai Wang, Jinyang Chen, Li Li · 2026 · Frontiers in Chemistry
  27. Senescent immune cells, inflammaging, and bone loss: therapeutic potential and translational challenges of senolytics in osteoporosis
    Minshun Zhu, Jie Zhang, Houshan Fang, Kuo Cai, Qing Wu, Changping Gao, Yueling Wang, Jiaping Chen · 2026 · Frontiers in Endocrinology
  28. A Mechanism‐Based Framework for Anti‐Aging Strategies: From Metabolic Regulation to Senotherapy and Stem Cell‐Based Interventions
    Feifei Li, Yankai Wang, Gelin Wang, Jack Chen, Song Huang · 2026 · Aging Cell
  29. Targeting Cellular Senescence and the Extracellular Matrix for Tissue Regeneration: Mechanistic Evidence and a Proposed Therapeutic Framework
    Jun‐Hyeog Jang · 2026 · Targets
  30. The aging secretome as a candidate driver of bone remodeling imbalance: myokines, adipokines, and senescence-associated secretory factors
    Hanhong Fang, Xianglong Zhou, Yang Liu, Weicheng Chen, Fulin Zhou, Haoran Zhou, Jianhui Xiang, Liming Xiong · 2026 · Frontiers in Endocrinology