The Senolytic Drug Navitoclax (ABT-263) Causes Trabecular Bone Loss and Impaired Osteoprogenitor Function in Aged Mice
Sharma, Anuj K., Roberts, Rachel L., Benson, Reginald D., Pierce, Jessica L., Yu, Kanglun, Hamrick, Mark W., McGee-Lawrence, Meghan E.·2020·Frontiers in Cell and Developmental Biology
Cited by (130)
Items 101–130 of 130
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- Assessing the Complexities of Utilizing BH3 Mimetics for a Senolytic Strategy in Combination with Ionizing RadiationMuruj A. Alshehri, Tareq Saleh, Mitchell Steven Anscher, Rowan A. Boyd, Hisashi Harada, David A. Gewirtz · 2026 · Radiation Research
- Dual-targeting Bcl-2-mediated apoptosis and synergistic pathways: Combinatorial strategies to overcome therapeutic resistance in cancerJiongjia Cheng, Haiying Wang, Yuchi Zhang, Guangxiang Liu · 2026 · Biochemical Pharmacology
- Slowing intervertebral disc aging in mice through long-term systemic treatment with the senolytic BCL-2/BCL-xL proteolysis targeting chimera (PROTAC) 753bPeter Geoffrey Alexander, Bowen Yan, Karen L. Clark, Qing D. Dong, D Wang, Yang Yang, Ting Zhang, Peiyi Zhang, Guangrong Zheng, Paul D. Robbins et al. · 2026 · Aging
- Interventional Strategies to Delay Aging-Related Dysfunctions of the Musculoskeletal SystemNaomasa Fukase, Ingrid Kvello Stake, Yoichi Murata, William S. Hambright, Sudheer K. Ravuri, Marc J. Philippon, Johnny Huard · 2021 · IntechOpen eBooks
- A geroscience approach for osteosarcopenia: Autophagy and senescence as therapeutic targetsNatanael Perez Cordero, Patricia Veronica Schoenlein, Sadanand Fulzele, William Hill · 2022 · Elsevier eBooks
- Stem cells, fitness, and agingKristina Viktorovna Kitaeva, Andrey Pavlovich Kiyasov, Albert Anatolyevich Rizvanov, Catrin Sian Rutland, Valeriya V. Solovyeva · 2022 · Elsevier eBooks
- Epigenetic Signatures of Aging: A Comprehensive Study of Biomarker DiscoveryMin Seob Lee, Hyukjung Kwon, Yonjung Kim, Na Young Min, So Young Lee, Isaac Kise Lee · 2023 · Advances in Aging Research
- Mild Uncoupling of Mitochondria Synergistically Enhances Senolytic Specificity and Sensitivity of Bh3 MimeticsEdward Fielder, Abbas Ishaq, Evon Low, Joseph Laws, Aisha Calista, Jemma Castle, Thomas von Zglinicki, Satomi Miwa · 2023 · SSRN Electronic Journal
- Clearance of senescent cells with ABT-263 improves biological functions of synovial mesenchymal stem cells from osteoarthritis patientsKentaro Endo, Yugo Miura, Keiichiro Komori, Ichiro Sekiya · 2022 · Research Square
- Preclinical evaluation of senescence-based strategies to improve cancer therapyAlejandra Estepa‐Fernández · 2022
- Therapy induced tumor cell senescence: mechanisms and ways to overcomeMaria A. Zamkova, Персиянцева Надежда Александровна, Victor Vyacheslavovich Tatarskiy, Alexander Albertovich Shtil · 2023 · Biochemistry (Moscow)
- Aktuelle und zukünftige pharmakologische Therapieoptionen zur Behandlung der Osteoporose und deren Wirkmechanismen – ein ÜberblickInes Fößl, Barbara Maria Obermayer-Pietsch · 2024 · Osteologie/Osteology
- Senescence And The Senescence Associated Secretory Phenotype In Salivary HypofunctionQuetsia Jean-Baptiste · 2024
- Stem cell-based strategies in osteoporosis: Pathophysiological insights and therapeutic perspectivesChao Xu · 2025 · New cell
- Senolytic Therapy as a Preventive Strategy for Low Back PainSaber Ghazizadeh Darband, Hosni Cherif, Matthew Mannarino, Juiena Sagir, Magali Millecamps, Jean Albert Ouellet, Laura S. Stone, Lisbet Haglund · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- Autofluorescence and cell size-based sorting eliminates senescent cells in synovial mesenchymal stem cells from patients with osteoarthritisKurea Sakuma, Kentaro Endo, Nobutake Ozeki, Hideyuki Koga, Ichiro Sekiya · 2026 · Tissue and Cell
- Exercise, Cellular Senescence, and Cancer: Novel Perspectives on Functional Aging Through Block Strength Training in Older Adults—A Narrative ReviewRodrigo L. Castillo, Emilio Jofré‐Saldía, Daniela Cáceres-Vergara, Georgina M. Renard, Esteban G. Figueroa · 2026 · Biomedicines
- Delivery timing determines senomorphic efficacy: delayed local ruxolitinib restores macrophage polarization and rescues age-impaired bone repairYamin Liu, Erin M. O’Brien, Christy Lottinger, Govindaraj Perumal, Kara L. Spiller, Liisa T. Kuhn · 2026 · Research Square
- Senolytic Therapy as a Preventive Strategy for Spine Degeneration and PainSaber Ghazizadeh Darband, Hosni Cherif, Matthew Mannarino, Juiena Sagir, Magali Millecamps, Jean Albert Ouellet, Laura S. Stone, Lisbet Haglund · 2026 · Advanced Science
- SENOLÍTICOS E A MODULAÇÃO DA SENESCÊNCIA CELULAR: IMPACTOS POTENCIAIS NA PREVENÇÃO DE DOENÇAS CARDIOVASCULARES E METABÓLICASRosiclerk Ottilo Cavassani Neto, Irlane Silva Veras, Leonardo Lucio Martins Teixeira, Gotardo Duarte Dumaresq Filho, Fernando Malachias de Andrade Bergamo, Chrystianne Ferreira da Silva Braz Cunha, Paulo Sérgio Silva Rocha, Clara Luquetti Paiva, BIANCA DA SILVA AMARANTE GOMES, Filipe Otavio Pimentel Gaspar · 2026 · RECIMA21 - Revista Científica Multidisciplinar
- Progress on novel compounds for the treatment of bone metabolism-related disorders: focus on osteoporosis and beyondYeqiong Song, Ruixing Zhang, Xinyue Zhang, Jingkai Wang, Jinyang Chen, Li Li · 2026 · Frontiers in Chemistry
- Senescent immune cells, inflammaging, and bone loss: therapeutic potential and translational challenges of senolytics in osteoporosisMinshun Zhu, Jie Zhang, Houshan Fang, Kuo Cai, Qing Wu, Changping Gao, Yueling Wang, Jiaping Chen · 2026 · Frontiers in Endocrinology
- A Mechanism‐Based Framework for Anti‐Aging Strategies: From Metabolic Regulation to Senotherapy and Stem Cell‐Based InterventionsFeifei Li, Yankai Wang, Gelin Wang, Jack Chen, Song Huang · 2026 · Aging Cell
- Targeting Cellular Senescence and the Extracellular Matrix for Tissue Regeneration: Mechanistic Evidence and a Proposed Therapeutic FrameworkJun‐Hyeog Jang · 2026 · Targets
- The aging secretome as a candidate driver of bone remodeling imbalance: myokines, adipokines, and senescence-associated secretory factorsHanhong Fang, Xianglong Zhou, Yang Liu, Weicheng Chen, Fulin Zhou, Haoran Zhou, Jianhui Xiang, Liming Xiong · 2026 · Frontiers in Endocrinology