The DOI matches its Crossref record; 336 of the 336 references it cites were found in a registry or an index.
Mitochondrial calcium cycling in neuronal function and neurodegeneration
Open accessAbstract
Mitochondria are essential for proper cellular function through their critical roles in ATP synthesis, reactive oxygen species production, calcium (Ca 2+ ) buffering, and apoptotic signaling. In neurons, Ca 2+ buffering is particularly important as it helps to shape Ca 2+ signals and to regulate numerous Ca 2+ -dependent functions including neuronal excitability, synaptic transmission, gene expression, and neuronal toxicity. Over the past decade, identification of the mitochondrial Ca 2+ uniporter (MCU) and other molecular components of mitochondrial Ca 2+ transport has provided insight into the roles that mitochondrial Ca 2+ regulation plays in neuronal function in health and disease. In this review, we discuss the many roles of mitochondrial Ca 2+ uptake and release mechanisms in normal neuronal function and highlight new insights into the Ca 2+ -dependent mechanisms that drive mitochondrial dysfunction in neurologic diseases including epilepsy, Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis. We also consider how targeting Ca 2+ uptake and release mechanisms could facilitate the development of novel therapeutic strategies for neurological diseases.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“excessive or prolonged activation of CaV channels leads to calcium overload in mitochondria, disrupting their normal function at multiple levels and significantly impacting cellular development and homeostasis101,102.”
From CYFIP1 governs the development of cortical axons by modulating calcium availability (2025) · cites this paper as [102]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Staging of brain pathology related to sporadic Parkinson’s disease
Braak, H., Tredici, K. D., Rüb, U., de Vos, R. A. I., Jansen Steur, E. N. H., & Braak, E. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00065-9 · Cited by 10,777
Down-Regulation of Na+/K+ATPase Activity by Human Parvovirus B19 Capsid Protein VP1
Almilaji, A., Szteyn, K., Fein, E., Pakladok, T., Muñoz, C., Elvira, B., Towhid, S. T., Alesutan, I., Shumilina, E. V., Bock, C. –., et al. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350083 · Cited by 8,700
Rosen, D. R., Siddique, T., Patterson, D., Figlewicz, D. A., Sapp, P., Hentati, A., Donaldson, D., Goto, J., O'Regan, J. P., Deng, H.-X., et al. (1993) · Nature · doi:10.1038/362059a0 · Cited by 7,062
The amyloid hypothesis of Alzheimer's disease at 25 years
Selkoe, D. J., & Hardy, J. (2016) · EMBO Molecular Medicine · doi:10.15252/emmm.201606210 · Cited by 6,164
Early Identification of Refractory Epilepsy
Kwan, P., & Brodie, M. J. (2000) · New England Journal of Medicine · doi:10.1056/nejm200002033420503 · Cited by 5,204 · cited 1×
“Unfortunately, 30% of patients have epilepsy that is poorly controlled by current pharmaceuticals, a condition referred to as refractory epilepsy (Kwan and Brodie, 2000).”
BackgroundShort-Term Synaptic Plasticity
Zucker, R. S., & Regehr, W. G. (2002) · Annual Review of Physiology · doi:10.1146/annurev.physiol.64.092501.114547 · Cited by 5,068
Querfurth, H. W., & LaFerla, F. M. (2010) · New England Journal of Medicine · doi:10.1056/nejmra0909142 · Cited by 4,569
Berg, A. T., Berkovic, S. F., Brodie, M. J., Buchhalter, J., Cross, J. H., Van Emde Boas, W., Engel, J., French, J., Glauser, T. A., Mathern, G. W., et al. (2010) · Epilepsia · doi:10.1111/j.1528-1167.2010.02522.x · Cited by 4,363
Motor Neuron Degeneration in Mice that Express a Human Cu,Zn Superoxide Dismutase Mutation
Gurney, M. E., Pu, H., Chiu, A. Y., Dal Canto, M. C., Polchow, C. Y., Alexander, D. D., Caliendo, J., Hentati, A., Kwon, Y. W., Deng, H.-X., et al. (1994) · Science · doi:10.1126/science.8209258 · Cited by 4,143
Interplay between Cortical Spreading Depolarization and Seizures
Kramer, D. R., Fujii, T., Ohiorhenuan, I. E., & Liu, C. Y. (2017) · Stereotactic and Functional Neurosurgery · doi:10.1159/000452841 · Cited by 3,721
Flagged first, then by citations
Research works printed but not linked: 1
- De Camilli, 2001, The structure of synapses, 89
Cited by
Sorted by citations
Items 101–105 of 105
Mohan, M., Mannan, A., Mondal, D., Chabara, C., Aneja, S., Subramaniyan, V., & Singh, T. G. (2026) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2026.104114
Woodbury, L. S., Angsutararux, P., Marras, M., Wagner, E., Abella, C., Li, A., & Silva, J. R. (2026) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2026.113565
Oxidant–antioxidant system alterations in LPS-induced sepsis: Modulatory effects of pregabalin
Çevik, D., Gümral, N., Aslankoç, R., Karanfil, E. S., Coşkun, A., & Yorulmaz, R. (2026) · Troia Medical Journal · doi:10.55665/troiamedj.1862825
Biomimetic Neurostimulation for the Enhancement of Lower-Limb Explosive Performance: A Pilot Study
Danilov, I. V., & Ābele, A. (2026) · Journal of Functional Morphology and Kinesiology · doi:10.3390/jfmk11040398
Zhang, X., Wu, Y., Han, J., Zhao, Z., Yao, Y., Sun, Y., & 王新志 (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1950139
Metadata
- Authors
- Walters, G. C., & Usachev, Y. M.
- Affiliations
- University of Iowa (US)
- Corresponding author
- Walters, Grant C.
- Usachev, Yuriy M.
- Venue
- Frontiers in Cell and Developmental Biology
- Publisher
- Frontiers Media SA
- Published
- 2023-01-24
- Volume
- 11
- Pages
- 1094356-1094356
- ISSN
- 2296-634X (ISSN-L)
- PMC
- PMC9902777
- OpenAlex
- W4317907766
- Cited by
- 105
- References
- 336
- Citations by year
- 2026: 35 · 2025: 37 · 2024: 22 · 2023: 11
- FWCI
- 2.77
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Cell and Developmental Biology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institutes of Health (NS125884)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Keywords
- mitochondrial calcium uniporter, mitochondrial calcium uptake, mitochondrial calcium release, calcium buffering, neuronal excitability, synaptic transmission, neurodegeneration, mitochondrial dysfunction, epilepsy, Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, reactive oxygen species, apoptosis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
