Mitochondrial calcium cycling in neuronal function and neurodegeneration

Mitochondrial Calcium Dysregulation Contributes to Dendrite Degeneration Mediated by PD/LBD-Associated LRRK2 Mutants

Verma, M., Callio, J., Otero, P. A., Sekler, I., Wills, Z. P., & Chu, C. T. (2017) · The Journal of Neuroscience · doi:10.1523/jneurosci.3791-16.2017 · Cited by 128

Letm1, the mitochondrial Ca 2+ /H + antiporter, is essential for normal glucose metabolism and alters brain function in Wolf–Hirschhorn syndrome

Jiang, D., Zhao, L., Clish, C. B., & Clapham, D. E. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1308558110 · Cited by 127

The mitochondrial permeability transition pore regulates Parkinson's disease development in mutant α-synuclein transgenic mice

Martin, L. J., Semenkow, S., Hanaford, A. R., & Wong, M. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.11.008 · Cited by 126

Genetic Convergence Brings Clarity to the Enigmatic Red Line in ALS

Cook, C. N., & Petrucelli, L. (2019) · Neuron · doi:10.1016/j.neuron.2019.02.032 · Cited by 126

Mitochondrial Ca2+ Signaling in Health, Disease and Therapy

Modesti, L., Danese, A., Vitto, V. A. M., Ramaccini, D., Aguiari, G., Gafà, R., Lanza, G., Giorgi, C., & Pinton, P. (2021) · Cells · doi:10.3390/cells10061317 · Cited by 123

The Interplay between Ca2+ Signaling Pathways and Neurodegeneration

Ureshino, R. P., Erustes, A. G., Bassani, T. B., Wachilewski, P., Guarache, G. C., Nascimento, A. C., Costa, A. J., Smaili, S. S., & Pereira, G. J. S. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20236004 · Cited by 122

Stimulation-Evoked Increases in Cytosolic [Ca2+] in Mouse Motor Nerve Terminals Are Limited by Mitochondrial Uptake and Are Temperature-Dependent

David, G., & Barrett, E. F. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-19-07290.2000 · Cited by 118

Molecular Cloning of a Sixth Member of the K+-dependent Na+/Ca2+ Exchanger Gene Family, NCKX6

Cai, X., & Lytton, J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m310908200 · Cited by 116

Parkinson’s disease-associated LRRK2-G2019S mutant acts through regulation of SERCA activity to control ER stress in astrocytes

Lee, J. H., Han, J., Kim, H., Park, S. M., Joe, E.-H., & Jou, I. (2019) · Acta Neuropathologica Communications · doi:10.1186/s40478-019-0716-4 · Cited by 113

The effect of ruthenium red on the uptake and release of Ca2+ by mitochondria

Rossi, C. S., Vasington, F. D., & Carafoli, E. (1973) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(73)91322-3 · Cited by 112

Mitochondrial diseases and epilepsy

Bindoff, L. A., & Engelsen, B. A. (2012) · Epilepsia · doi:10.1111/j.1528-1167.2012.03618.x · Cited by 110

Ca2+ handling at the mitochondria-ER contact sites in neurodegeneration

Lim, D., Dematteis, G., Tapella, L., Genazzani, A. A., Calí, T., Brini, M., & Verkhratsky, A. (2021) · Cell Calcium · doi:10.1016/j.ceca.2021.102453 · Cited by 109

Unresolved questions from the analysis of mice lacking MCU expression

Murphy, E., Pan, X., Nguyen, T. T. M., Liu, J., Holmström, K. M., & Finkel, T. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2014.04.144 · Cited by 108

Dissection of Mitochondrial Ca2+ Uptake and Release Fluxes in Situ after Depolarization-Evoked [Ca2+]i Elevations in Sympathetic Neurons

Colegrove, S. L., Albrecht, M. A., & Friel, D. D. (2000) · The Journal of General Physiology · doi:10.1085/jgp.115.3.351 · Cited by 107

Mitochondria and Neurotransmission: Evacuating the Synapse

Hollenbeck, P. J. (2005) · Neuron · doi:10.1016/j.neuron.2005.07.017 · Cited by 107

Dysregulation of Intracellular Calcium Signaling in Alzheimer's Disease

Александровна, П. Е., Pchitskaya, E. I., & Борисович, Б. И. (2018) · Antioxidants and Redox Signaling · doi:10.1089/ars.2018.7506 · Cited by 106

Mitochondrial Calcium Deregulation in the Mechanism of Beta-Amyloid and Tau Pathology

Esteras, N., & Abramov, A. Y. (2020) · Cells · doi:10.3390/cells9092135 · Cited by 106

Regulation of dendritic development by calcium signaling

Redmond, L., & Ghosh, A. (2005) · Cell Calcium · doi:10.1016/j.ceca.2005.01.009 · Cited by 104

Mitochondrial Clearance of Cytosolic Ca2+in Stimulated Lizard Motor Nerve Terminals Proceeds without Progressive Elevation of Mitochondrial Matrix [Ca2+]

David, G. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-17-07495.1999 · Cited by 103

Excitatory Dendritic Mitochondrial Calcium Toxicity: Implications for Parkinson’s and Other Neurodegenerative Diseases

Verma, M., Wills, Z. P., & Chu, C. T. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00523 · Cited by 103

Amyloid β Oligomers Increase ER-Mitochondria Ca2+ Cross Talk in Young Hippocampal Neurons and Exacerbate Aging-Induced Intracellular Ca2+ Remodeling

Calvo-Rodríguez, M., Hernando-Pérez, E., Núñez, L., & Villalobos, C. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00022 · Cited by 103

Memantine for dementia

Areosa, S. A., Sherriff, F., & McShane, R. H. (2005) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003154.pub3 · Cited by 103

Store-Operated Ca2+Entry in Sensory Neurons: Functional Role and the Effect of Painful Nerve Injury

Gemes, G., Bangaru, M. L. Y., Wu, H.-E., Tang, Q., Weihrauch, D., Koopmeiners, A. S., Cruikshank, J. M., Kwok, W., & Hogan, Q. H. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.5053-10.2011 · Cited by 103

Tau inhibits mitochondrial calcium efflux and makes neurons vulnerable to calcium-induced cell death

Britti, E., Ros, J., Esteras, N., & Abramov, A. Y. (2019) · Cell Calcium · doi:10.1016/j.ceca.2019.102150 · Cited by 101

The cytosolic N-terminus of presenilin-1 potentiates mouse ryanodine receptor single channel activity

Rybalchenko, V., Hwang, S., Rybalchenko, N., & Koulen, P. (2007) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2007.06.023 · Cited by 99

Defining the molecular mechanisms of the mitochondrial permeability transition through genetic manipulation of F-ATP synthase

Carrer, A., Tommasin, L., Šileikytė, J., Ciscato, F., Filadi, R., Urbani, A., Forte, M. A., Rasola, A., Szabó, I., Carraro, M., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-25161-x · Cited by 96

Donut-Like Topology of Synaptic Vesicles with a Central Cluster of Mitochondria Wrapped into Membrane Protrusions: A Novel Structure–Function Module of the Adult Calyx of Held

Wimmer, V. C., Horstmann, H., Groh, A., & Kuner, T. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.3268-05.2006 · Cited by 93

Mitochondrial Ca2+ uptake by the MCU facilitates pyramidal neuron excitability and metabolism during action potential firing

Groten, C. J., & MacVicar, B. A. (2022) · Communications Biology · doi:10.1038/s42003-022-03848-1 · Cited by 93

Inhibition of the mitochondrial calcium uniporter rescues dopaminergic neurons in pink1−/− zebrafish

Soman, S. K., Keatinge, M., Moein, M., Costa, M. D., Mortiboys, H., Skupin, A., Sugunan, S., Bazała, M. A., Kuźnicki, J., & Bandmann, O. (2016) · European Journal of Neuroscience · doi:10.1111/ejn.13473 · Cited by 91

Mitochondrial DNA Mutation-Elicited Oxidative Stress, Oxidative Damage, and Altered Gene Expression in Cultured Cells of Patients with MERRF Syndrome

Wu, S., Ma, Y., Wu, Y., Chen, Y.-C., & Wei, Y. (2010) · Molecular Neurobiology · doi:10.1007/s12035-010-8123-7 · Cited by 90

Mitochondrial Ca2+Buffering Regulates Synaptic Transmission Between Retinal Amacrine Cells

Medler, K. F., & Gleason, E. L. (2002) · Journal of Neurophysiology · doi:10.1152/jn.00627.2001 · Cited by 90

Calcium: the Darth Vader of ALS

Appel, S. H., Beers, D. R., Siklós, L., Engelhardt, J., & Mosier, D. R. (2001) · Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders · doi:10.1080/146608201300079418 · Cited by 88

The mitochondrial Ca2+ uptake regulator, MICU1, is involved in cold stress-induced ferroptosis

Nakamura, T., Ogawa, M., Kojima, K., Takayanagi, S., Ishihara, S., Hattori, K., Naguro, I., & Ichijo, H. (2021) · EMBO Reports · doi:10.15252/embr.202051532 · Cited by 87

Roles for Mitochondrial and Reverse Mode Na+/Ca2+Exchange and the Plasmalemma Ca2+ATPase in Post-Tetanic Potentiation at Crayfish Neuromuscular Junctions

Zhong, N., Beaumont, V., & Zucker, R. S. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-24-09598.2001 · Cited by 86

Calcium signaling in neuroglia

Lim, D., Semyanov, A. V., Genazzani, A. A., & Verkhratsky, A. (2021) · International review of cytology · doi:10.1016/bs.ircmb.2021.01.003 · Cited by 86

Target Cell-Specific Involvement of Presynaptic Mitochondria in Post-Tetanic Potentiation at Hippocampal Mossy Fiber Synapses

Lee, D., Lee, K.-H., Ho, W., & Lee, S. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.3985-07.2007 · Cited by 85

Inhibitors of the mitochondrial calcium uniporter for the treatment of disease

Woods, J. J., & Wilson, J. J. (2019) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2019.11.006 · Cited by 84

Changes in [Ca 2+ ] i and membrane currents during impaired mitochondrial metabolism in dissociated rat hippocampal neurons

Nowicky, A. V., & Duchen, M. R. (1998) · The Journal of Physiology · doi:10.1111/j.1469-7793.1998.131bu.x · Cited by 84

The mitochondrial Na+/Ca2+ exchanger

Palty, R., & Sekler, I. (2012) · Cell Calcium · doi:10.1016/j.ceca.2012.02.010 · Cited by 83

Reconstitution, identification, purification, and immunological characterization of the 110-kDa Na+/Ca2+ antiporter from beef heart mitochondria.

Li, W., Shariat‐Madar, Z., Powers, M. A., Sun, X. C., Lane, R. D., & Garlid, K. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)37140-6 · Cited by 82

Comparative Impact of Voltage-Gated Calcium Channels and NMDA Receptors on Mitochondria-Mediated Neuronal Injury

Stanika, R. I., Villanueva, I., Kazanina, G., Andrews, S. B., & Pivovarova, N. B. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.6008-11.2012 · Cited by 81

Correlated Calcium Uptake and Release by Mitochondria and Endoplasmic Reticulum of CA3 Hippocampal Dendrites after Afferent Synaptic Stimulation

Pivovarova, N. B., Pozzo‐Miller, L. D., Hongpaisan, J., & Andrews, S. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-24-10653.2002 · Cited by 81

Mitochondrial Ca2+Cycling Facilitates Activation of the Transcription Factor NFAT in Sensory Neurons

Kim, M., & Usachev, Y. M. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.3384-09.2009 · Cited by 79

Regulation of ATP production: dependence on calcium concentration and respiratory state

Fink, B. D., Bai, F., Yu, L. P., & Sivitz, W. I. (2017) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00086.2017 · Cited by 79

Mitochondrial Ca2+Uptake Regulates the Excitability of Myenteric Neurons

Berghe, P. V., Kenyon, J. L., & Smith, T. K. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-16-06962.2002 · Cited by 79

Effects of antiepileptic drugs on mitochondrial functions, morphology, kinetics, biogenesis, and survival

Finsterer, J., & Scorza, F. A. (2017) · Epilepsy Research · doi:10.1016/j.eplepsyres.2017.07.003 · Cited by 75

Presynaptic Mitochondria in Functionally Different Motor Neurons Exhibit Similar Affinities for Ca2+But Exert Little Influence as Ca2+Buffers at Nerve Firing RatesIn Situ

Chouhan, A. K., Zhang, J., Zinsmaier, K. E., & Macleod, G. T. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.4701-09.2010 · Cited by 74

A new mouse line with reduced GluA2 Q/R site RNA editing exhibits loss of dendritic spines, hippocampal CA1-neuron loss, learning and memory impairments and NMDA receptor-independent seizure vulnerability

Konen, L. M., Wright, A. L., Royle, G. A., Morris, G. P., Lau, B. K., Seow, P. W., Zinn, R., Milham, L. T., Vaughan, C. W., & Vissel, B. (2020) · Molecular Brain · doi:10.1186/s13041-020-0545-1 · Cited by 74

Focal Cerebral Ischemia and Reperfusion Induce Brain Injury Through α2δ-1–Bound NMDA Receptors

Luo, Y., Ma, H., Zhou, J., Li, L., Chen, S.-R., Zhang, J., Chen, L., & Pan, H. (2018) · Stroke · doi:10.1161/strokeaha.118.022330 · Cited by 74

Modulating Ca2 clearance from neurons

Thayer, S. A. (2002) · Frontiers in bioscience · doi:10.2741/a838 · Cited by 73

The mechanism of MICU-dependent gating of the mitochondrial Ca2+uniporter

Garg, V., Suzuki, J., Paranjpe, I., Unsulangi, T., Boyman, L., Milescu, L. S., Lederer, W. J., & Kirichok, Y. (2021) · eLife · doi:10.7554/elife.69312 · Cited by 73

Calcium-Dependent Inhibition of L, N, and P/Q Ca2+Channels in Chromaffin Cells: Role of Mitochondria

Hernández-Guijo, J. M., Maneu-Flores, V. E., Ruíz‐Nuño, A., Villarroya, M., Garcı́a, A. G., & Gandı́a, L. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-08-02553.2001 · Cited by 73

Calcium‐induced precipitate formation in brain mitochondria: composition, calcium capacity, and retention

Kristián, T., Pivovarova, N. B., Fiskum, G. M., & Andrews, S. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04626.x · Cited by 72

Mitochondrial Calcium Uptake Modulates Synaptic Vesicle Endocytosis in Central Nerve Terminals

Marland, J. R. K., Hasel, P., Bonnycastle, K., & Cousin, M. A. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.686956 · Cited by 72

Restriction of mitochondrial calcium overload by mcu inactivation renders neuroprotective effect in Zebrafish models of Parkinson's disease

Soman, S. K., Bazała, M. A., Keatinge, M., Bandmann, O., & Kuźnicki, J. (2019) · Biology Open · doi:10.1242/bio.044347 · Cited by 72

The cell-permeable mitochondrial calcium uniporter inhibitor Ru265 preserves cortical neuron respiration after lethal oxygen glucose deprivation and reduces hypoxic/ischemic brain injury

Novorolsky, R. J., Nichols, M. T., Kim, J. S., Pavlov, E. V., Woods, J. J., Wilson, J. J., & Robertson, G. S. (2020) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x20908523 · Cited by 72

MCUb Induction Protects the Heart From Postischemic Remodeling

Huo, J., Lü, S., Kwong, J. Q., Bround, M. J., Grimes, K. M., Sargent, M. A., Brown, M. E., Davis, M. E., Bers, D. M., & Molkentin, J. D. (2020) · Circulation Research · doi:10.1161/circresaha.119.316369 · Cited by 72

N-Acetylcysteine Prevents the Spatial Memory Deficits and the Redox-Dependent RyR2 Decrease Displayed by an Alzheimer’s Disease Rat Model

More, J., Galusso, N., Veloso, P., Montecinos, L., Finkelstein, J. P., Sánchez, G., Bull, R., Valdés, J. L., Hidalgo, C., & Paula-Lima, A. C. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00399 · Cited by 71

Identification and functional validation of FDA-approved positive and negative modulators of the mitochondrial calcium uniporter

Mario, A. D., Tosatto, A., Hill, J. M., Kriston-Vizi, J., Ketteler, R., Reane, D. V., Cortopassi, G. A., Szabadkai, G., Rizzuto, R., & Mammucari, C. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109275 · Cited by 71

Mitochondrial ROS control neuronal excitability and cell fate in frontotemporal dementia

Esteras, N., Kopach, O., Maiolino, M., Lariccia, V., Amoroso, S., Qamar, S., Wray, S., Rusakov, D. A., Jaganjac, M., & Abramov, A. Y. (2021) · Alzheimer s & Dementia · doi:10.1002/alz.12394 · Cited by 70

Aspects of calcium-activated chloride currents: A neuronal perspective

Scott, R. H., Sutton, K. G., Griffin, A., Stapleton, S. R., & Currie, K. (1995) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(95)00018-c · Cited by 70

The Mitochondrial Ca2+ uniporter is a central regulator of interorganellar Ca2+ transfer and NFAT activation

Yoast, R. E., Emrich, S. M., Zhang, X., Xin, P., Arige, V., Pathak, T., Benson, J. C., Johnson, M. T., Abdelnaby, A. E., Lakomski, N., et al. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.101174 · Cited by 69

Quantitative Analysis of Mitochondrial Ca2+ Uptake and Release Pathways in Sympathetic Neurons

Colegrove, S. L., Albrecht, M. A., & Friel, D. D. (2000) · The Journal of General Physiology · doi:10.1085/jgp.115.3.371 · Cited by 68

Cytosolic Calcium Coordinates Mitochondrial Energy Metabolism with Presynaptic Activity

Chouhan, A. K., Ivannikov, M. V., Lu, Z., Sugimori, M., Llinás, R. R., & Macleod, G. T. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.1301-11.2012 · Cited by 68

Gabapentin Administration Reduces Reactive Gliosis and Neurodegeneration after Pilocarpine-Induced Status Epilepticus

Rossi, A., Angelo, M. F., Villarreal, A., Lukin, J., & Ramos, A. J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0078516 · Cited by 68

Pharmacological inhibition of the mitochondrial Ca2+ uniporter: Relevance for pathophysiology and human therapy

Márta, K., Hasan, P., Rodríguez-Prados, M., Paillard, M., & Hajnóczky, G. (2020) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2020.09.014 · Cited by 68

Ion and inhibitor binding of the double-ring ion selectivity filter of the mitochondrial calcium uniporter

Cao, C., Wang, S., Cui, T., Su, X., & Chou, J. J. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1620316114 · Cited by 67

The Ψ m depolarization that accompanies mitochondrial Ca 2+ uptake is greater in mutant SOD1 than in wild-type mouse motor terminals

Nguyen, K. T. V., Garcia-Chacon, L. E., Barrett, J. N., Barrett, E. F., & David, G. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0810934106 · Cited by 65

Cardiac arrhythmia and neuroexcitability gene variants in resected brain tissue from patients with sudden unexpected death in epilepsy (SUDEP)

Friedman, D. J., Kannan, K. S., Faustin, A., Shroff, S., Thomas, C., Heguy, A., Serrano, J., Snuderl, M., & Devinsky, O. (2018) · npj Genomic Medicine · doi:10.1038/s41525-018-0048-5 · Cited by 65

EMRE is essential for mitochondrial calcium uniporter activity in a mouse model

Liu, J. C., Syder, N. C., Ghorashi, N. S., Willingham, T. B., Parks, R. J., Sun, J., Fergusson, M. M., Liu, J., Holmström, K. M., Menazza, S., et al. (2020) · JCI Insight · doi:10.1172/jci.insight.134063 · Cited by 65

Excitotoxicity Revisited: Mitochondria on the Verge of a Nervous Breakdown

Plotegher, N., Filadi, R., Pizzo, P., & Duchen, M. R. (2021) · Trends in Neurosciences · doi:10.1016/j.tins.2021.01.001 · Cited by 65

Mitochondria as regulators of stimulus-evoked calcium signals in neurons

Friel, D. D. (2000) · Cell Calcium · doi:10.1054/ceca.2000.0172 · Cited by 64

Mitochondrial calcium uniporter deletion prevents painful diabetic neuropathy by restoring mitochondrial morphology and dynamics

George, D., Hackelberg, S., Jayaraj, N. D., Ren, D., Edassery, S. L., Rathwell, C. A., Miller, R. E., Malfait, A., Savas, J. N., Miller, R. J., et al. (2021) · Pain · doi:10.1097/j.pain.0000000000002391 · Cited by 64

Deletion of mitochondrial calcium uniporter incompletely inhibits calcium uptake and induction of the permeability transition pore in brain mitochondria

Hamilton, J., Brustovetsky, T., Rysted, J., Lin, Z., Usachev, Y. M., & Brustovetsky, N. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.002926 · Cited by 63

Accumulation of Exogenous Amyloid- Beta Peptide in Hippocampal Mitochondria Causes Their Dysfunction: A Protective Role for Melatonin

Rosales‐Corral, S., Acuña-Castroviejo, D., Tan, D. X., López-Armas, G. D. C., Cruz-Ramos, J. A., Munoz, R., Melnikov, V., Manchester, L. C., & Reiter, R. J. (2012) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2012/843649 · Cited by 61

Cytosolic, but not matrix, calcium is essential for adjustment of mitochondrial pyruvate supply

Szibor, M., Gizatullina, Z. Z., Gainutdinov, T. M., Endres, T., Dębska–Vielhaber, G., Kunz, M., Karavasili, N., Hallmann, K., Schreiber, F., Bamberger, A., et al. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.011902 · Cited by 61

Mitochondrial Free Ca2+ Levels and Their Effects on Energy Metabolism in Drosophila Motor Nerve Terminals

Ivannikov, M. V., & Macleod, G. T. (2013) · Biophysical Journal · doi:10.1016/j.bpj.2013.03.064 · Cited by 60

Extrusion of Ca2+ from mouse motor terminal mitochondria via a Na+–Ca2+ exchanger increases post‐tetanic evoked release

Garcia-Chacon, L. E., Nguyen, K. T. V., David, G., & Barrett, E. F. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.110841 · Cited by 58

Inhibiting the Mitochondrial Calcium Uniporter during Development Impairs Memory in Adult Drosophila

Drago, I., & Davis, R. L. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.08.017 · Cited by 58

Selective mitochondrial Ca 2+ uptake deficit in disease endstage vulnerable motoneurons of the SOD1 G93A mouse model of amyotrophic lateral sclerosis

Fuchs, A., Kutterer, S., Mühling, T., Duda, J., Schütz, B., Liss, B., Keller, B. U., & Roeper, J. (2013) · The Journal of Physiology · doi:10.1113/jphysiol.2012.247981 · Cited by 58

Tamoxifen-induced knockdown of the mitochondrial calcium uniporter in Thy1-expressing neurons protects mice from hypoxic/ischemic brain injury

Nichols, M. T., Pavlov, E. V., & Robertson, G. S. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-0607-9 · Cited by 56

Resolving the Micro-Macro Disconnect to Address Core Features of Seizure Networks

Farrell, J. S., Nguyen, Q.-A., & Soltész, I. (2019) · Neuron · doi:10.1016/j.neuron.2019.01.043 · Cited by 56

Regulation of Mitochondrial Ca 2+ Uptake

Murphy, E., & Steenbergen, C. (2020) · Annual Review of Physiology · doi:10.1146/annurev-physiol-031920-092419 · Cited by 56

Dysfunction of Mitochondrial Ca2+ Regulatory Machineries in Brain Aging and Neurodegenerative Diseases

Jung, H., Kim, S. Y., Cecen, F. S. C., Cho, Y., & Kwon, S. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.599792 · Cited by 56

Aberrant activity of mitochondrial NCLX is linked to impaired synaptic transmission and is associated with mental retardation

Stavsky, A., Stoler, O., Kostić, M., Katoshevski, T., Assali, E. A., Azoulay, I. S., Amitai, Y., Prokisch, H., Leiz, S., Daumer‐Haas, C., et al. (2021) · Communications Biology · doi:10.1038/s42003-021-02114-0 · Cited by 55

Uncontrolled mitochondrial calcium uptake underlies the pathogenesis of neurodegeneration in MICU1-deficient mice and patients

Singh, R., Bartók, Á., Paillard, M., Tyburski, A. L., Elliott, M. B., & Hajnóczky, G. (2022) · Science Advances · doi:10.1126/sciadv.abj4716 · Cited by 55

Malignancies after mitoxantrone for multiple sclerosis

Buttmann, M., Seuffert, L., Mäder, U., & Toyka, K. V. (2016) · Neurology · doi:10.1212/wnl.0000000000002745 · Cited by 55

Quantitative estimate of mitochondrial [Ca2+] in stimulated motor nerve terminals

David, G., Talbot, J. D., & Barrett, E. F. (2003) · Cell Calcium · doi:10.1016/s0143-4160(02)00229-4 · Cited by 54

Targeting mitochondrial calcium pathways as a potential treatment against Parkinson’s disease

Dey, K., Bazała, M. A., & Kuźnicki, J. (2020) · Cell Calcium · doi:10.1016/j.ceca.2020.102216 · Cited by 53

Astrocytic Calcium and cAMP in Neurodegenerative Diseases

Sobolczyk, M., & Boczek, T. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.889939 · Cited by 53

α2δ-1 switches the phenotype of synaptic AMPA receptors by physically disrupting heteromeric subunit assembly

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