The DOI matches its Crossref record; 263 of the 263 references it cites were found in a registry or an index.
Reassessing the Host Defense Peptide Landscape
Open accessAbstract
Current research has demonstrated that small cationic amphipathic peptides have strong potential not only as antimicrobials, but also as antibiofilm agents, immune modulators, and anti-inflammatories. Although traditionally termed antimicrobial peptides (AMPs) these additional roles have prompted a shift in terminology to use the broader term host defense peptides (HDPs) to capture the multi-functional nature of these molecules. In this review, we critically examined the role of AMPs and HDPs in infectious diseases and inflammation. It is generally accepted that HDPs are multi-faceted mediators of a wide range of biological processes, with individual activities dependent on their polypeptide sequence. In this context, we explore the concept of chemical space as it applies to HDPs and hypothesize that the various functions and activities of this class of molecule exist on independent but overlapping activity landscapes. Finally, we outline several emerging functions and roles of HDPs and highlight how an improved understanding of these processes can potentially be leveraged to more fully realize the therapeutic promise of HDPs.
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Self-citationMolecular mechanisms of antibiotic resistance
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Cited by
Innate Inspiration: Antifungal Peptides and Other Immunotherapeutics From the Host Immune Response
Mercer, D. K., & O'Neil, D. A. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.02177 · Cited by 50
Metadata
- Authors
- Haney, E. F., Straus, S. K., & Hancock, R. E. W.
- Venue
- Frontiers in Chemistry
- Publisher
- Frontiers Media SA
- Published
- 2019-02-04
- Volume
- 7
- Pages
- 43-43
- ISSN
- 2296-2646 (ISSN-L)
- OpenAlex
- W2914213905
- Cited by
- 359
- References
- 263
- FWCI
- 34.69
- Type
- journal article
- Language
- en
- Open access
- gold
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- Haney, E. F., Straus, S. K., & Hancock, R. E. W. (2019). Reassessing the Host Defense Peptide Landscape. Frontiers in Chemistry. https://doi.org/10.3389/fchem.2019.00043
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
