The DOI matches its Crossref record; 247 of the 247 references it cites were found in a registry or an index.
New Perspectives on the Use of Phytochemicals as an Emergent Strategy to Control Bacterial Infections Including Biofilms
Open accessAbstract
The majority of current infectious diseases are almost untreatable by conventional antibiotic therapy given the advent of multidrug-resistant bacteria. The degree of severity and the persistence of infections are worsened when microorganisms form biofilms. Therefore, efforts are being applied to develop new drugs not as vulnerable as the current ones to bacterial resistance mechanisms, and also able to target bacteria in biofilms. Natural products, especially those obtained from plants, have proven to be outstanding compounds with unique properties, making them perfect candidates for these much-needed therapeutics. This review presents the current knowledge on the potentialities of plant products as antibiotic adjuvants to restore the therapeutic activity of drugs. Further, the difficulties associated with the use of the existing antibiotics in the treatment of biofilm-related infections are described. To counteract the biofilm resistance problems, innovative strategies are suggested based on literature data. Among the proposed strategies, the use of phytochemicals to inhibit or eradicate biofilms is highlighted. An overview on the use of phytochemicals to interfere with bacterial quorum sensing (QS) signaling pathways and underlying phenotypes is provided. The use of phytochemicals as chelating agents and efflux pump inhibitors is also reviewed.
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Cites
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Biofilms: Microbial Life on Surfaces
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Molecular mechanisms of antibiotic resistance
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The Involvement of Cell-to-Cell Signals in the Development of a Bacterial Biofilm
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Cited by
Borges, A., José, H., Homem, V., & Simões, M. (2020) · Antibiotics · doi:10.3390/antibiotics9020048 · Cited by 184
“These are primarily used to protect themselves from external stresses and pathogen attacks [3].”
BackgroundSelf-citationMorguette, A. E. B., Bartolomeu-Gonçalves, G., Andriani, G. M., Bertoncini, G. E. S., de Castro, I. M., de Almeida Spoladori, L. F., Bertão, A. M. S., Tavares, E. R., Yamauchi, L. M., & Yamada-Ogatta, S. F. (2023) · Plants · doi:10.3390/plants12112147 · Cited by 31
Metadata
- Authors
- Borges, A., Abreu, A., Dias, C., Saavedra, M., Borges, F., & Simões, M.
- Venue
- Molecules
- Publisher
- MDPI AG
- Published
- 2016-07-05
- Volume
- 21
- Issue
- 7
- Pages
- 877
- ISSN
- 1420-3049 (ISSN-L)
- OpenAlex
- W2467458514
- Cited by
- 308
- References
- 247
- FWCI
- 9.18
- Type
- journal article
- Language
- en
- Open access
- gold
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- Borges, A., Abreu, A., Dias, C., Saavedra, M., Borges, F., & Simões, M. (2016). New Perspectives on the Use of Phytochemicals as an Emergent Strategy to Control Bacterial Infections Including Biofilms. Molecules. https://doi.org/10.3390/molecules21070877
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
