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Cited by 76Research on Leishmaniasis StudiesLeprosy Research and TreatmentParasitic Diseases Research and Treatment

Histological Disorganization of Spleen Compartments and Severe Visceral Leishmaniasis

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Hermida, Micely d'El-Rei, de Melo, Caroline Vilas Boas, Lima, Isadora dos Santos, Oliveira, Geraldo Gileno de Sá, dos-Santos, Washington L. C.·2018·Frontiers in Cellular and Infection Microbiology
DOI 10.3389/fcimb.2018.00394PMC PMC6243053
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Abstract

The spleen is a secondary lymphoid organ responsible for immune surveillance against blood-circulating pathogens. Absence of the spleen is associated with increased susceptibility to systemic spread and fatal infection by different pathogens. Severe forms of visceral leishmaniasis are associated with disorganization of spleen compartments where cell interactions essential for splenic immunological function take place. White pulp atrophies, secondary lymphoid follicles and marginal zones vanish, and the boundaries separating white and red pulp blur. Leukocyte populations are reduced or disappear or are replaced by plasma cells. In this paper, we review the published data on spleen disorganization in severe forms of visceral leishmaniasis and propose a histological classification to help the exchange of information among research groups.

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  • As splenomegaly develops, the pink vascular spaces of the spleen and lymphoid follicles are encroached upon by infiltrating neutrophils, resulting in obstruction of venous outflow and abnormal enlargement.

    “As splenomegaly developed, the pink vascular spaces of the spleen and lymphoid follicles were encroached upon by infiltrating neutrophils [46]. This results in the obstruction of venous outflow of blood and abnormal enlargement in size.”

    From Age, sex and Alzheimer’s disease: a longitudinal study of 3xTg-AD mice reveals sex-specific disease trajectories and inflammatory responses mirrored in postmortem brains from Alzheimer’s patients (2024) · cites this paper as [46]

    The ‘Spleen disorganization in VL’ section (page unavailable) describes spleen enlargement and progressive disruption of lymphoid follicles. It identifies macrophages and plasma cells in the affected compartments, but does not say that infiltrating neutrophils encroach on vascular spaces or follicles, or that they obstruct venous outflow. Its mention of increased neutrophils concerns blood counts in dogs, not splenic infiltration. (LLM, conf=0.88)

    Experimental — accuracy not yet measured

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Cited by

Sorted by citations

Authors
Hermida, M. D.-R., de Melo, C. V. B., Lima, I. D. S., Oliveira, G. G. D. S., & dos-Santos, W. L. C.
Affiliations
Instituto Gonçalo Moniz (BR)
ORCID
Venue
Frontiers in Cellular and Infection Microbiology
Publisher
Frontiers Media SA
Published
2018-11-13
Volume
8
Pages
394-394
ISSN
2235-2988 (ISSN-L)
DOI
10.3389/fcimb.2018.00394
PMC
PMC6243053
OpenAlex
W2901292332
Cited by
76
References
0
Citations by year
2026: 9 · 2025: 8 · 2024: 15 · 2023: 6 · 2022: 13 · 2021: 15 · 2020: 6 · 2019: 4
FWCI
1.12
Type
journal article
Language
en
Open access
Licence
Locations
  • Frontiers in Cellular and Infection Microbiology (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
  • Americanae (AECID Library) (submittedVersion, other-oa)
  • Arca - Repositório Institucional da Fiocruz (submittedVersion, other-oa)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (AUXPE-CAPES-FAPESB 2072/2013/PROCESSO #23038.006718/2013-19, 23038, 2072/2013)
  • Governo Brasil
  • Conselho Nacional de Desenvolvimento Científico e Tecnológico (400905/2013-2)
  • Fundação de Amparo à Pesquisa do Estado da Bahia (PET0053/2013)
  • Fundação Oswaldo Cruz (PROEP grant 400905/2013-2)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Research on Leishmaniasis Studies
  • Health Sciences › Medicine › Infectious Diseases › Leprosy Research and Treatment
  • Health Sciences › Medicine › Infectious Diseases › Parasitic Diseases Research and Treatment
Keywords
visceral leishmaniasis, spleen histology, marginal zone, secondary lymphoid follicles, leukocyte depletion, plasma cells, histological classification, immune surveillance
MeSH terms
Animals, Chronic Disease, Humans, Leishmaniasis, Visceral, Leukocytes, Spleen, Leishmania infantum

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