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Cited by 17Diabetes, Cardiovascular Risks, and LipoproteinsPregnancy and preeclampsia studiesGestational Diabetes Research and Management

Prevalence of metabolic syndrome in women after maternal complications of pregnancy: an observational cohort analysis

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Aldridge, Emily, Pathirana, Maleesa, Wittwer, Melanie, Sierp, Susan, Leemaqz, Shalem Y., Roberts, Claire T., Dekker, Gustaaf A., Arstall, Margaret A.·2022·Frontiers in Cardiovascular Medicine
DOI 10.3389/fcvm.2022.853851PMC PMC8963931
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Abstract

Introduction: Certain complications of pregnancy, including hypertensive disorders of pregnancy, gestational diabetes mellitus, intrauterine growth restriction, spontaneous preterm birth, and placental abruption, are established independent risk factors for premature cardiovascular disease in women. Metabolic syndrome, which is associated with an increased risk of cardiovascular disease, may be a suitable alternative to traditional cardiovascular risk calculators that underestimate risk in young women. This study aimed to investigate the prevalence of metabolic syndrome in women who experienced a complicated pregnancy 6 months earlier. Methods: This observational study investigated the prevalence of metabolic syndrome as defined by the International Diabetes Federation in all eligible participants ( n = 247) attending a postpartum lifestyle intervention clinic from August 2018 to June 2021 at the Lyell McEwin Hospital in Adelaide, South Australia. Results: A total of 89 (36%) participants met the criteria for metabolic syndrome at a mean follow up time of 7 months postpartum. Almost 90% of the cohort were abdominally obese, and over two thirds of the total cohort met at least two of the criteria for metabolic syndrome. Conclusions: Women with a prior history of one of the common major pregnancy complications are at high risk of future cardiovascular and metabolic disease, with many showing either metabolic syndrome or multiple risk factors at only 7 months postpartum. The results indicate that follow-up within 1 year postpartum is an appropriate time to commence preventative strategies, as many women are already showing early signs of disease.

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  • Women with pregnancy complications have a higher risk of developing metabolic syndrome in the future.

    “In addition, women with pregnancy complications have a higher risk of developing metabolic syndrome in the future, which underscores the importance of pregnancy as an important period to measure metabolic health (3).”

    From Maternal nutritional status and the risk of metabolic syndrome in pregnancy: implications for public health nutrition (2026) · cites this paper as [3]

    The Discussion reports metabolic syndrome in 36% of women with a major prior pregnancy complication at six months postpartum and cites a comparison of 34% after hypertensive pregnancy versus 5% after normotensive pregnancy. However, it says the study could not assess whether metabolic syndrome developed after pregnancy or progressed over time; some participants may already have had it before conception. The claim's implication of future development goes beyond those findings. (LLM, conf=0.87)

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Cited by

Sorted by citations

Authors
Aldridge, E., Pathirana, M., Wittwer, M., Sierp, S., Leemaqz, S. Y., Roberts, C. T., Dekker, G. A., & Arstall, M. A.
Affiliations
  • The University of Adelaide (AU)
  • Flinders University (AU)
Corresponding author
Aldridge, Emily
ORCID
Venue
Frontiers in Cardiovascular Medicine
Publisher
Frontiers Media SA
Published
2022-03-14
Volume
9
Pages
853851-853851
ISSN
2297-055X (ISSN-L)
DOI
10.3389/fcvm.2022.853851
PMC
PMC8963931
OpenAlex
W4220861541
Cited by
17
References
7
Citations by year
2026: 6 · 2025: 5 · 2024: 1 · 2023: 3 · 2022: 2
FWCI
2.04
Type
journal article
Language
en
Open access
Licence
Locations
  • Frontiers in Cardiovascular Medicine (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Hospital Research Foundation
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
  • Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
Keywords
metabolic syndrome, pregnancy complications, postpartum women, cardiovascular risk, gestational diabetes mellitus, hypertensive disorders of pregnancy, fetal growth restriction, preterm birth, placental abruption, abdominal obesity, cardiovascular disease prevention

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