The DOI matches its Crossref record; 80 of the 80 references it cites were found in a registry or an index.
Cholecystokinin—From Local Gut Hormone to Ubiquitous Messenger
Open accessAbstract
Cholecystokinin (CCK) was discovered 1928 in jejunal extracts as a gallbladder contraction factor. It was later shown to be member of a peptide family which are all ligands for the CCK1 and CCK2 receptors. CCK peptides are known to be synthetized in small intestinal endocrine I-cells and cerebral neurons. But in addition, CCK is expressed in several endocrine glands (pituitary cells, thyroid C-cells, pancreatic islets, the adrenals, the testes); in peripheral nerves; in cortical and medullary kidney cells; in cardial myocytes; and in cells of the immune system. CCK peptides stimulate pancreatic enzyme secretion and growth, gallbladder contraction, gut motility, satiety, and inhibit acid secretion from the stomach. Moreover, they are major neurotransmitters in the brain and the periphery. CCK peptides also stimulate calcitonin, insulin, and glucagon secretion, and they may act as natriuretic peptides in the kidneys. CCK peptides are derived from proCCK with a C-terminal bioactive YMGWMDFamide sequence, in which the Y-residue is partly O-sulfated. The plasma forms are CCK-58, -33, -22, and -8, whereas the small CCK-8 and -5 are potent neurotransmitters. Over the last decades, CCK-expression has also been encountered in tumors (neuroendocrine tumors, cerebral astrocytomas, gliomas, acoustic neuromas, and specific pediatric tumors). Recently, a metastastic islet cell tumor was found to cause a specific CCKoma syndrome, suggesting that circulating CCK may be a useful tumor marker.
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Self-citationRehfeld, J. F. (1978) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)34793-2 · Cited by 807
Self-citationAbdominal Vagotomy Blocks the Satiety Effect of Cholecystokinin in the Rat
Smith, G. P., Jerome, C., Cushin, B. J., Eterno, R., & Simansky, K. J. (1981) · Science · doi:10.1126/science.7268408 · Cited by 804
Liddle, R. A., Goldfine, I. D., Rosen, M. S., Taplitz, R. A., & Williams, J. A. (1985) · Journal of Clinical Investigation · doi:10.1172/jci111809 · Cited by 745
Evidence for coexistence of dopamine and CCK in meso-limbic neurones
Hökfelt, T., Rehfeld, J. F., Skirboll, L., Ivemark, B., Goldstein, M., & Markey, K. (1980) · Nature · doi:10.1038/285476a0 · Cited by 707
Self-citationA HORMONE MECHANISM FOR GALL-BLADDER CONTRACTION AND EVACUATION
Ivy, A. C., & Oldberg, E. (1928) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1928.86.3.599 · Cited by 691
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Self-citationCholecystokinin elicits Satiety in Rats with Open Gastric Fistulas
GIBBS, J., YOUNG, R. C., & SMITH, G. P. (1973) · Nature · doi:10.1038/245323a0 · Cited by 534
Expression cloning and characterization of the canine parietal cell gastrin receptor.
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Cited by
Recent advances in neuropeptide signaling in Drosophila, from genes to physiology and behavior
Nässel, D. R., & Zandawala, M. (2019) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2019.02.003 · Cited by 355
Fukui, H., Xu, X., & Miwa, H. (2018) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm18071 · Cited by 128
Rehfeld, J. F., Knop, F. K., Asmar, A., Madsbad, S., Holst, J. J., & Asmar, M. (2018) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365521.2018.1530297 · Cited by 62
Self-citationGether, I. M., Nexøe-Larsen, C., & Knop, F. K. (2019) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2018-01008 · Cited by 56
Nesti, L., Mengozzi, A., & Tricò, D. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00144 · Cited by 53
Metadata
- Authors
- Rehfeld, J. F.
- Venue
- Frontiers in Endocrinology
- Publisher
- Frontiers Media SA
- Published
- 2017-04-13
- Volume
- 8
- Pages
- 47-47
- ISSN
- 1664-2392 (ISSN-L)
- OpenAlex
- W2606711325
- Cited by
- 265
- References
- 80
- FWCI
- 9.39
- Type
- journal article
- Language
- en
- Open access
- gold
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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