Cited by 282Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and MetabolismRegulation of Appetite and Obesity

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Cytokines and Abnormal Glucose and Lipid Metabolism

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Shi, Jie, Fan, Jiangao, Su, Qing, Yang, Zhen·2019·Frontiers in Endocrinology

DOI 10.3389/fendo.2019.00703PMC PMC6833922

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Abstract

Clear evidence indicates that cytokines, for instance, adipokines, hepatokines, inflammatory cytokines, myokines, and osteokines, contribute substantially to the development of abnormal glucose and lipid metabolism. Some cytokines play a positive role in metabolism action, while others have a negative metabolic role linking to the induction of metabolic dysfunction. The mechanisms involved are not fully understood, but are associated with lipid accumulation in organs and tissues, especially in the adipose and liver tissue, changes in energy metabolism, and inflammatory signals derived from various cell types, including immune cells. In this review, we describe the roles of certain cytokines in the regulation of metabolism and inter-organ signaling in regard to the pathophysiological aspects. Given the disease-related changes in circulating levels of relevant cytokines, these factors may serve as biomarkers for the early detection of metabolic disorders. Moreover, based on preclinical studies, certain cytokines that can induce improvements in glucose and lipid metabolism and immune response may emerge as novel targets of broader and more efficacious treatments and prevention of metabolic disease.

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Authors: Shi, J., Fan, J., Su, Q., & Yang, Z.
Affiliations: Shanghai Jiao Tong University (CN)
Corresponding author: Su, Qing
Yang, Zhen
ORCID: Shi, Jie
Su, Qing
Yang, Zhen
Venue: Frontiers in Endocrinology
Publisher: Frontiers Media SA
Published: 2019-10-30
Volume: 10
Pages: 703-703
ISSN: 1664-2392 (ISSN-L)
DOI: 10.3389/fendo.2019.00703
PMC: PMC6833922
OpenAlex: W2982649663
Cited by: 282
References: 222
Citations by year: 2026: 27 · 2025: 39 · 2024: 37 · 2023: 52 · 2022: 66 · 2021: 46 · 2020: 14 · 2019: 1
FWCI: 4.61
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Frontiers in Endocrinology (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: National Natural Science Foundation of China (81670743, 81370953)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords: cytokines, adipokines, hepatokines, myokines, osteokines, glucose metabolism, lipid metabolism, metabolic dysfunction, lipid accumulation, energy metabolism, inflammation, immune cells, biomarkers, metabolic disorders, therapeutic target

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Cytokines and Abnormal Glucose and Lipid Metabolism

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