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Cited by 110Nuclear Receptors and SignalingT-cell and B-cell ImmunologyPsoriasis: Treatment and Pathogenesis

Role of the Orphan Nuclear Receptor NR4A Family in T-Cell Biology

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Odagiu, Livia, May, Julia, Boulet, Salix, Baldwin, Troy A., Labrecque, Nathalie·2021·Frontiers in Endocrinology
DOI 10.3389/fendo.2020.624122PMC PMC7883379
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Abstract

The nuclear orphan receptors NR4A1, NR4A2, and NR4A3 are immediate early genes that are induced by various signals. They act as transcription factors and their activity is not regulated by ligand binding and are thus regulated via their expression levels. Their expression is transiently induced in T cells by triggering of the T cell receptor following antigen recognition during both thymic differentiation and peripheral T cell responses. In this review, we will discuss how NR4A family members impact different aspects of the life of a T cell from thymic differentiation to peripheral response against infections and cancer.

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  • NR4A1 and other NR4A family members have an immunomodulatory role in mature cell types, most commonly in T cells and macrophages.

    “NR4A1 and other NR4A family members are known for their immunomodulatory role in mature cell types, most commonly in T cell and macrophages [83,84].”

    From Clonal hematopoiesis and inflammation – the perpetual cycle (2023) · cites this paper as [84]

    The “NR4As and Peripheral CD4+ T Cell Responses” section describes immunomodulatory functions of NR4A1 and other NR4A members in mature T cells, including maintenance of Treg identity. The paper mentions macrophages as cells helped by CD4+ T cells, but does not establish an NR4A role in macrophages or the claim that T cells and macrophages are the most common cell types for that role. Page numbers were not available in our copy. (LLM, conf=0.85)

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Authors
Odagiu, L., May, J., Boulet, S., Baldwin, T. A., & Labrecque, N.
Affiliations
  • Hôpital Maisonneuve-Rosemont (CA)
  • University of Alberta (CA)
Corresponding author
  • Baldwin, Troy A.
  • Labrecque, Nathalie
ORCID
Venue
Frontiers in Endocrinology
Publisher
Frontiers Media SA
Published
2021-02-01
Volume
11
Pages
624122-624122
ISSN
1664-2392 (ISSN-L)
DOI
10.3389/fendo.2020.624122
PMC
PMC7883379
OpenAlex
W3127186093
Cited by
110
References
135
Citations by year
2026: 20 · 2025: 22 · 2024: 19 · 2023: 26 · 2022: 15 · 2021: 8
FWCI
2.57
Type
journal article
Language
en
Open access
Licence
Locations
  • Frontiers in Endocrinology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Canadian Institutes of Health Research (MOP 142333, PJT 168910, PS 156104)
  • Natural Sciences and Engineering Research Council of Canada (RGPIN-2015-06645)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nuclear Receptors and Signaling
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Keywords
orphan nuclear receptor, Nur77, Nurr1, NR4A3, T cells, thymic differentiation, T cell receptor signaling, immediate early genes, transcription factors, antiviral immunity, antitumor immunity, tumor immunology
MeSH terms
Animals, DNA-Binding Proteins, Humans, Receptors, Antigen, T-Cell, Receptors, Steroid, Receptors, Thyroid Hormone, T-Lymphocytes, Thymus Gland, Signal Transduction, Nuclear Receptor Subfamily 4, Group A, Member 1, Nuclear Receptor Subfamily 4, Group A, Member 2

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