Sarcopenia and menopause: The role of estradiol
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decrease in quality and muscle function) occurs. This muscle dysfunction, caused by decreased proliferation of muscle satellite cells, increased levels of inflammatory markers, and altered levels of sex hormones, exposes women to a raised incidence of sarcopenia. In this regard, hormonal balance and, in particular, estradiol, seems to be essential in skeletal muscle function. The role of the estradiol on satellite cells and the release of inflammatory cytokines in menopausal women are reviewed. In particular, estradiol has a beneficial effect on the skeletal muscle by stimulating satellite cell proliferation. Skeletal muscle can respond to estrogenic hormonal control due to the presence of specific receptors for estradiol at the level of muscle fibers. Additionally, estradiol can limit inflammatory stress damage on skeletal muscle. In this review, we primarily focused on the role of estradiol in sarcopenia and on the possibility of using Estradiol Replacement Therapy, which combined with nutritional and physical activity programs, can counteract this condition representing a valid tool to treat sarcopenia in women.
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Age-related decreases in sex steroid hormones in both men and women are implicated as critical factors in the development of sarcopenia.
“Along with mitochondrial alteration, age-related decreases in sex steroid hormones in both men and women have been implicated as critical factors in the development of sarcopenia (21, 22).”
From From mitochondria to sarcopenia: role of 17β-estradiol and testosterone (2023) · cites this paper as [21]
Reduction of estradiol concentrations attenuated satellite cell proliferation, and the ability to maintain muscle mass and strength.
“It was reported that reduction of estradiol concentrations attenuated satellite cell proliferation, and the ability to maintain muscle mass and strength (43).”
From The role of obesity in sarcopenia and the optimal body composition to prevent against sarcopenia and obesity (2023) · cites this paper as [43]
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References 46 · Cited by 238
- Authors
- Geraci, A., Calvani, R., Ferri, E., Marzetti, E., Arosio, B., & Cesari, M.
- Affiliations
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
- Stockholm University (SE)
- Università Cattolica del Sacro Cuore (IT)
- University of Milan (IT)
- Corresponding author
- Geraci, Annalisa
- Venue
- Frontiers in Endocrinology
- Publisher
- Frontiers Media SA
- Published
- 2021-05-19
- Volume
- 12
- Pages
- 682012-682012
- ISSN
- 1664-2392 (ISSN-L)
- PMC
- PMC8170301
- OpenAlex
- W3160416967
- Cited by
- 238
- References
- 46
- Citations by year
- 2026: 52 · 2025: 71 · 2024: 48 · 2023: 38 · 2022: 22 · 2021: 6
- FWCI
- 3.80
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Endocrinology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- PubliCatt (Università Cattolica del Sacro Cuore) (submittedVersion, cc-by)
- Topics
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Keywords
- sarcopenia, menopause, estradiol, skeletal muscle function, satellite cells, satellite cell proliferation, inflammatory cytokines, estrogen receptor, estradiol replacement therapy, sex hormones, muscle quality, women
- MeSH terms
- Estradiol, Female, Humans, Inflammation, Menopause, Stem Cells, Muscle, Skeletal, Sarcopenia
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