The DOI matches its Crossref record; 386 of the 386 references it cites were found in a registry or an index.
Endometriosis-associated infertility: From pathophysiology to tailored treatment
Open accessAbstract
Despite the clinically recognized association between endometriosis and infertility, the mechanisms implicated in endometriosis-associated infertility are not fully understood. Endometriosis is a multifactorial and systemic disease that has pleiotropic direct and indirect effects on reproduction. A complex interaction between endometriosis subtype, pain, inflammation, altered pelvic anatomy, adhesions, disrupted ovarian reserve/function, and compromised endometrial receptivity as well as systemic effects of the disease define endometriosis-associated infertility. The population of infertile women with endometriosis is heterogeneous, and diverse patients’ phenotypes can be observed in the clinical setting, thus making difficult to establish a precise diagnosis and a single mechanism of endometriosis related infertility. Moreover, clinical management of infertility associated with endometriosis can be challenging due to this heterogeneity. Innovative non-invasive diagnostic tools are on the horizon that may allow us to target the specific dysfunctional alteration in the reproduction process. Currently the treatment should be individualized according to the clinical situation and to the suspected level of impairment. Here we review the etiology of endometriosis related infertility as well as current treatment options, including the roles of surgery and assisted reproductive technologies.
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Cited by
Impact of endometriosis on the ovarian follicles
Casalechi, M., Di Stefano, G., Fornelli, G., Somigliana, E., & Viganò, P. (2024) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2023.102430 · Cited by 31
Impact of surgery for endometriosis on the outcomes of in vitro fertilization
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“Furthermore, the cellular dissemination hypothesis proposes that endometrial cells spread via blood or lymphatic pathways, accounting for rare cases of extra-abdominal endometriosis [3,4].”
Metadata
- Authors
- Bonavina, G., & Taylor, H. S.
- Venue
- Frontiers in Endocrinology
- Publisher
- Frontiers Media SA
- Published
- 2022-10-26
- Volume
- 13
- Pages
- 1020827-1020827
- ISSN
- 1664-2392 (ISSN-L)
- OpenAlex
- W4307553503
- Cited by
- 319
- References
- 386
- FWCI
- 41.28
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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