The DOI matches its Crossref record; 206 of the 206 references it cites were found in a registry or an index.
Aging conundrum: A perspective for ovarian aging
Open accessAbstract
Progressive loss of physiological integrity and accumulation of degenerative changes leading to functional impairment and increased susceptibility to diseases are the main features of aging. The ovary, the key organ that maintains female reproductive and endocrine function, enters aging earlier and faster than other organs and has attracted extensive attention from society. Ovarian aging is mainly characterized by the progressive decline in the number and quality of oocytes, the regulatory mechanisms of which have yet to be systematically elucidated. This review discusses the hallmarks of aging to further highlight the main characteristics of ovarian aging and attempt to explore its clinical symptoms and underlying mechanisms. Finally, the intervention strategies related to aging are elaborated, especially the potential role of stem cells and cryopreservation of embryos, oocytes, or ovarian tissue in the delay of ovarian aging.
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“The age-related reproductive aging is a natural and irreversible physiological process, especially for oocytes [2].”
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NADase CD38 is a key determinant of ovarian aging
Yang, Q., Chen, W., Cong, L., Wang, M., Li, H., Wang, H., Luo, X., Zhu, J., Zeng, X., Zhu, Z., et al. (2023) · Nature Aging · doi:10.1038/s43587-023-00532-9 · Cited by 108
Aging hallmarks of the primate ovary revealed by spatiotemporal transcriptomics
Lu, H., Jing, Y., Zhang, C., Ma, S., Zhang, W., Huang, D., Zhang, B., Zuo, Y., Qin, Y., Liu, G., et al. (2023) · Protein & Cell · doi:10.1093/procel/pwad063 · Cited by 74
New insight into the role of macrophages in ovarian function and ovarian aging
Tang, M., Zhao, M., & Shi, Y. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1282658 · Cited by 52
Systemic low-dose anti-fibrotic treatment attenuates ovarian aging in the mouse
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Uterine Aging and Reproduction: Dealing with a Puzzle Biologic Topic
Tinelli, A., Andjić, M., Morciano, A., Pecorella, G., Malvası, A., D’Amato, A., & Sparić, R. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms25010322 · Cited by 40
Metadata
- Authors
- Wu, J., Liu, Y., Song, Y., Wang, L., Ai, J., & Li, K.
- Affiliations
- Tongji Hospital (CN)
- Corresponding author
- Wang, Lingjuan
- Ai, Jihui
- Li, Kezhen
- Venue
- Frontiers in Endocrinology
- Publisher
- Frontiers Media SA
- Published
- 2022-08-19
- Volume
- 13
- Pages
- 952471-952471
- ISSN
- 1664-2392 (ISSN-L)
- PMC
- PMC9437485
- OpenAlex
- W4292336387
- Cited by
- 73
- References
- 206
- Citations by year
- 2026: 19 · 2025: 18 · 2024: 19 · 2023: 16 · 2022: 1
- FWCI
- 2.68
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Endocrinology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
- Keywords
- ovarian aging, oocyte quality, hallmarks of aging, female reproductive aging, stem cells, oocyte cryopreservation, ovarian tissue cryopreservation
- MeSH terms
- Animals, Female, Oocytes, Ovary, Reproduction, Cryopreservation
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