The mitochondrial basis of aging

The Hallmarks of Aging

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Aging: a theory based on free radical and radiation chemistry

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Inflamm‐aging: An Evolutionary Perspective on Immunosenescence

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Pleiotropy, natural selection, and the evolution of senescence.

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Circulating mitochondrial DAMPs cause inflammatory responses to injury

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Identification and Characterization of MAVS, a Mitochondrial Antiviral Signaling Protein that Activates NF-κB and IRF3

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The Loss of Skeletal Muscle Strength, Mass, and Quality in Older Adults: The Health, Aging and Body Composition Study

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Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

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Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

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The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy

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Premature ageing in mice expressing defective mitochondrial DNA polymerase

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The Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson’s Disease

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Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis

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Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging

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Mitochondrial dysfunction in the elderly: possible role in insulin resistance

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Exercise Metabolism and the Molecular Regulation of Skeletal Muscle Adaptation

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Mitochondrial DNA stress primes the antiviral innate immune response

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Extension of murine life span by overexpression of catalase targeted to mitochondria

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NAD+ Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus

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Antioxidants prevent health-promoting effects of physical exercise in humans

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FoxOs Are Critical Mediators of Hematopoietic Stem Cell Resistance to Physiologic Oxidative Stress

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Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging

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Mitochondrial Dynamics in the Regulation of Nutrient Utilization and Energy Expenditure

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Nicotinamide Mononucleotide, a Key NAD+ Intermediate, Treats the Pathophysiology of Diet- and Age-Induced Diabetes in Mice

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Telomere dysfunction induces metabolic and mitochondrial compromise

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Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation

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The NAD+/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling

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Mitochondrial pathology and apoptotic muscle degeneration in <i>Drosophila parkin</i> mutants

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Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure

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MITOCHONDRIAL DNA MUTATIONS AS AN IMPORTANT CONTRIBUTOR TO AGEING AND DEGENERATIVE DISEASES

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Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells

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Rates of Behavior and Aging Specified by Mitochondrial Function During Development

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Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts

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The role of exercise and PGC1α in inflammation and chronic disease

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The Cell Non-Autonomous Nature of Electron Transport Chain-Mediated Longevity

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Mitonuclear protein imbalance as a conserved longevity mechanism

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Mitochondrial Import Efficiency of ATFS-1 Regulates Mitochondrial UPR Activation

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A mitochondrial specific stress response in mammalian cells

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Feedback between p21 and reactive oxygen production is necessary for cell senescence

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Intracellular α-ketoglutarate maintains the pluripotency of embryonic stem cells

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Apoptotic Caspases Suppress mtDNA-Induced STING-Mediated Type I IFN Production

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A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity

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NIX is required for programmed mitochondrial clearance during reticulocyte maturation

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A new pathway for mitochondrial quality control: Mitochondrial-derived vesicles

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The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy

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Apoptotic Caspases Prevent the Induction of Type I Interferons by Mitochondrial DNA

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Metabolic Regulation of Hematopoietic Stem Cells in the Hypoxic Niche

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Mito-Morphosis: Mitochondrial Fusion, Fission, and Cristae Remodeling as Key Mediators of Cellular Function

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Mitochondrial threshold effects

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Detection of a specific mitochondrial DNA deletion in tissues of older humans

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Coordination of mitophagy and mitochondrial biogenesis during ageing in C. elegans

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Defective Mitophagy in XPA via PARP-1 Hyperactivation and NAD+/SIRT1 Reduction

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Measuring In Vivo Mitophagy

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Transcriptional coactivator PGC-1α controls the energy state and contractile function of cardiac muscle

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Ras Proteins Induce Senescence by Altering the Intracellular Levels of Reactive Oxygen Species

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Regulation of mitochondrial biogenesis in skeletal muscle by CaMK

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A PGC-1α isoform induced by resistance training regulates skeletal muscle hypertrophy

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Canonical Nlrp3 Inflammasome Links Systemic Low-Grade Inflammation to Functional Decline in Aging

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A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence

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A Mitochondrial Superoxide Signal Triggers Increased Longevity in Caenorhabditis elegans

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Stem cells and the impact of ROS signaling

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PGC1α and mitochondrial metabolism – emerging concepts and relevance in ageing and neurodegenerative disorders

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An early age increase in vacuolar pH limits mitochondrial function and lifespan in yeast

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Signaling pathways controlling skeletal muscle mass

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New roles for mitochondrial proteases in health, ageing and disease

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Asymmetric apportioning of aged mitochondria between daughter cells is required for stemness

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Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence

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A mitochondrial UPR-mediated metabolic checkpoint regulates hematopoietic stem cell aging

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The matrix peptide exporter HAF-1 signals a mitochondrial unfolded protein response by activating the transcription factor ZC376.7 in C. elegans

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The PINK1-Parkin pathway promotes both mitophagy and selective respiratory chain turnover in vivo

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Bmi1 regulates mitochondrial function and the DNA damage response pathway

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Mitochondrial and Nuclear Accumulation of the Transcription Factor ATFS-1 Promotes OXPHOS Recovery during the UPRmt

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Mistargeted mitochondrial proteins activate a proteostatic response in the cytosol

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SIRT3 Reverses Aging-Associated Degeneration

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Impaired insulin/IGF1 signaling extends life span by promoting mitochondrial L-proline catabolism to induce a transient ROS signal

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Sirtuin 4 is a lipoamidase regulating pyruvate dehydrogenase complex activity

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Mitochondrial Dysfunction Leads to Nuclear Genome Instability via an Iron-Sulfur Cluster Defect

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The accumulation of misfolded proteins in the mitochondrial matrix is sensed by PINK1 to induce PARK2/Parkin-mediated mitophagy of polarized mitochondria

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The three ‘P’s of mitophagy: PARKIN.; PINK1.; and post-translational modifications

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Muscle Mitohormesis Promotes Longevity via Systemic Repression of Insulin Signaling

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Low oxygen concentration extends the lifespan of cultured human diploid cells

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Inhibition of p21‐mediated ROS accumulation can rescue p21‐induced senescence

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Mitochondrial UPR-regulated innate immunity provides resistance to pathogen infection

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A cytosolic network suppressing mitochondria-mediated proteostatic stress and cell death

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Exercise training increases mitochondrial biogenesis in the brain

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