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Cited by 33

The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.

Effects of the ketogenic diet on bone health: A systematic review

Garofalo, Vincenzo, Barbagallo, Federica, Cannarella, Rossella, Calogero, Aldo Eugenio, La Vignera, Sandro, Condorelli, Rosita Angela·2023·Frontiers in Endocrinology
DOI 10.3389/fendo.2023.1042744
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Abstract

Objective: To carry out a systematic review of published studies to evaluate the relationship between different type of ketogenic diet (KD) and bone health as supported by the scientific literature. Methods: The study involved all articles that assessed the relationship between the use of KD for the treatment of overweight or obesity and bone health. The quality assessment was evaluated with using the Cambridge Quality Checklists. The search strategy included the following combination of Medical Subjects Headings terms and keywords: “osteoporosis”, ”bone health, ”bone function”, ”bone mineral density”, and “ketogenic diet”. Results: Seven trials were identified and reviewed. No significant changes in bone mass density (BMD) were observed after KD. The results showed no significant effect on bone resorption by measuring urinary N-telopeptide levels, on bone formation by measuring bone-specific alkaline phosphatase, or alterations in overall bone turnover in patients who followed KD. Only in female subject after a 10% weight loss, bone resorption increases while new bone synthesis decreases, but without increasing the risk of osteoporosis. Finally, patients on KD lost significantly more weight than controls, associated with an increase in serum vitamin D levels and a reduction in plasma parathyroid hormone (PTH) levels. Conclusion: No human studies have currently been conducted with adequate and powerful experimental designs to definitively understand the impact of KD therapy on bone health.

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Research works printed but not linked: 31

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Cited by

Metadata

Authors
Garofalo, V., Barbagallo, F., Cannarella, R., Calogero, A. E., La Vignera, S., & Condorelli, R. A.
Venue
Frontiers in Endocrinology
Publisher
Frontiers Media SA
Published
2023-02-02
Volume
14
ISSN
1664-2392
DOI
10.3389/fendo.2023.1042744
Cited by
33
References
6
Licence
creativecommons.org/licenses/by/4.0/ (vor)

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