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Obesity and Circulating Levels of Vitamin D before and after Weight Loss Induced by a Very Low-Calorie Ketogenic Diet
Open accessAbstract
Background: Vitamin D plays a pivotal role in calcium and phosphorus metabolism, also influencing bone tissue. Several studies have reported that vitamin D blood levels were significantly lower in people with obesity, probably due to its uptake by the adipose tissue. Clinical studies that investigated the changes of circulating levels of vitamin D following weight loss reported controversial data. A very low-calorie ketogenic diet is acknowledged as a reliable treatment to achieve a rapid weight loss. Therefore, we investigated the effect of weight loss, consequent to a very low-calorie ketogenic diet, on vitamin D blood concentrations. Methods: A cohort of 31 people with obesity underwent a very low-calorie ketogenic diet for 10–12 weeks. The serum concentrations of vitamin D, parathormone, calcium and phosphorous were measured before and after weight loss; they were compared to a control group of 20 non-obese, non-diabetic, age- and gender-matched persons. Results: Patients with obesity had a higher habitual intake of vitamin D than the control group (p < 0.05). However, the vitamin D blood levels of the obese group were significantly lower than those of the control group (p < 0.005) and they increased after weight loss (p < 0.001). At baseline, vitamin D blood concentrations of the persons with obesity were significantly correlated with both fat mass–kg (r = −0.40; p < 0.05) and body mass index (r = −0.47; p < 0.01). Following very low-calorie ketogenic diet, the change in vitamin D serum concentrations was correlated only with the change in fat mass–kg (r = −0.43; p < 0.01). Conclusion: This study confirmed that patients with obesity have lower vitamin D levels that normalize after significant weight loss, supporting the hypothesis that vitamin D is stored in the adipose tissue and released following weight loss.
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Vitamin D is stored in adipose tissue and released after weight loss.
“Thus, this study supports the hypothesis that vitamin D is stored in adipose tissue and released after weight loss.”
From Ketogenic Diet as Medical Prescription in Women with Polycystic Ovary Syndrome (PCOS) (2023) · cites this paper as [44]
In 31 subjects with obesity, vitamin D levels increased after 10-12 weeks of VLCKD and the increase correlated with reduction in body weight and especially fat mass.
“Subjects with obesity had lower vitamin D levels, and at the end of the 10–12 weeks dietary intervention, the increase in vitamin D levels correlated with the reduction in body weight and especially fat mass [44].”
From Ketogenic Diet as Medical Prescription in Women with Polycystic Ovary Syndrome (PCOS) (2023) · cites this paper as [44]
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Ketogenic Diet as Medical Prescription in Women with Polycystic Ovary Syndrome (PCOS)
Barrea, L., Verde, L., Camajani, E., Cernea, S., Frias-Toral, E., Lamabadusuriya, D., Ceriani, F., Savastano, S., Colao, A., & Muscogiuri, G. (2023) · Current Nutrition Reports · doi:10.1007/s13668-023-00456-1 · Cited by 62
Metadata
- Authors
- Buscemi, S., Buscemi, C., Corleo, D., De Pergola, G., Caldarella, R., Meli, F., Randazzo, C., Milazzo, S., Barile, A. M., Rosafio, G., Settipani, V., Gurrera, S., Borzì, A. M., & Ciaccio, M.
- Affiliations
- Azienda Ospedaliera Universitaria Policlinico "Paolo Giaccone" di Palermo (IT)
- Department of Biomedical Science and Human Oncology, School of Medicine, Policlinico, University of Bari, 70124 Bari, Italy
- Corresponding author
- Buscemi, Silvio
- ORCID
- Venue
- Nutrients
- Publisher
- MDPI AG
- Published
- 2021-05-27
- Volume
- 13
- Issue
- 6
- Pages
- 1829
- ISSN
- 2072-6643 (ISSN-L)
- PMC
- PMC8226843
- OpenAlex
- W3164088268
- Cited by
- 32
- References
- 26
- Citations by year
- 2026: 2 · 2025: 8 · 2024: 6 · 2023: 9 · 2022: 6 · 2021: 1
- FWCI
- 3.66
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Nutrients (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Nova Science Publishers (Nova Science Publishers, Inc.) (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Vitamin D Research Studies
- Health Sciences › Medicine › Physiology (medical) › Diet and metabolism studies
- Health Sciences › Nursing › Nutrition and Dietetics › Vitamin K Research Studies
- Keywords
- vitamin D, obesity, very low-calorie ketogenic diet, weight loss, serum vitamin D levels, parathyroid hormone, calcium and phosphorus metabolism, body mass index, fat mass
- MeSH terms
- Adipose Tissue, Adult, Female, Humans, Male, Middle Aged, Obesity, Parathyroid Hormone, Vitamin D, Cohort Studies, Weight Loss, Diet, Ketogenic
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