Development of Therapeutic-Grade Small Interfering RNAs by Chemical Engineering
Bramsen, Jesper B., Kjems, Jørgen·2012·Frontiers in Genetics
Cites (266)
Items 201–278 of 278
- Toll‐like receptor (TLR) 3 immune modulation by unformulated small interfering RNA or DNA and the role of CD14 (in TLR‐mediated effects)Cordula Weber, Christian Müller, Anja Podszuweit, Carmen Montino, Jörg Vollmer, Alexandra Forsbach · 2012 · Immunology
- A Status Update of Modified Oligonucleotides for Chemotherapeutics ApplicationsYogesh S. Sanghvi · 2011 · Current Protocols in Nucleic Acid Chemistry
- High doses of siRNAs induce eri-1 and adar-1 gene expression and reduce the efficiency of RNA interference in the mouseJie Hong, Zhikang Qian, Shuiyuan Shen, Taishan Min, Chang Tan, Jianfeng Xu, Yingchun Zhao, Weida Huang · 2005 · Biochemical Journal
- Integrated Magnetic Bionanocomposites through Nanoparticle-Mediated Assembly of FerritinSudhanshu Srivastava, Bappaditya Samanta, Brian J. Jordan · 2007 · Journal of the American Chemical Society
- Gene Silencing Activity of siRNA Molecules Containing Phosphorodithioate SubstitutionsXianbin Yang, Małgorzata Sierant, Magdalena Janicka, Łukasz Pęczek, Carlos Martinez, Tom Hassell, Na Li, Xin Li, Tianzhi Wang, Barbara Nawrot · 2012 · ACS Chemical Biology
- LNA (LOCKED NUCLEIC ACID) AND THE DIASTEREOISOMERIC α-L-LNA: CONFORMATIONAL TUNING AND HIGH-AFFINITY RECOGNITION OF DNA/RNA TARGETSJesper Wengel, Michael Åxman Petersen, Kathrine E. Nielsen, Gitte A. Jensen, Anders E. Håkansson, Ravindra Kumar, Mads D. Sørensen, Vivek K. Rajwanshi, Torsten Bryld, Jens Peter Jacobsen · 2001 · Nucleosides Nucleotides & Nucleic Acids
- Biochemical properties of phosphonoacetate and thiophosphonoacetate oligodeoxyribonucleotidesDavid M. Sheehan · 2003 · Nucleic Acids Research
- The siRNA sequence and guide strand overhangs are determinants of in vivo duration of silencingWalter R. Strapps, Victoria Pickering, Gladys T. Muiru, Julie Rice, Stacey Orsborn, Barry A. Polisky, Alan B. Sachs, Steven R. Bartz · 2010 · Nucleic Acids Research
- TLR3-mediated NF-κB signaling in human esophageal epithelial cellsDiana M. Lim, Sneha Narasimhan, Carmen Z. Michaylira, Mei‐Lun Wang · 2009 · American Journal of Physiology-Gastrointestinal and Liver Physiology
- Small Interfering RNAs Induce Target-Independent Inhibition of Tumor Growth and Vasculature Remodeling in a Mouse Model of Hepatocellular CarcinomaMathieu Bergé, Philippe Bonnin, Eric Sulpice, José Vilar, David Allanic, Jean‐Sébastien Silvestre, Bernard I Levy, Gordon C. Tucker, Gérard Tobelem, Tatyana Merkulova‐Rainon · 2010 · American Journal Of Pathology
- In Situ Analysis of Single-Stranded and Duplex siRNA Integrity in Living CellsKoen Raemdonck, Katrien Remaut, Bart Lucas, Niek N. Sanders, Jo Demeester, Stefaan C. De Smedt · 2006 · Biochemistry
- Chemically Modified Short Interfering Hybrids (siHYBRIDS): Nanoimmunoliposome DeliveryIn VitroandIn Vivofor RNAi of HER-2Richard I. Hogrefe, Alexandre V. Lebedev, Gerald Zon, Kathleen F. Pirollo, Antonina S. Rait, Qi Zhou, Wei Yu, Esther H. Chang · 2006 · Nucleosides Nucleotides & Nucleic Acids
- Synthesis of 2′-O-modified adenosine building blocks and application for RNA interferenceDalibor Odadzic, Jesper B. Bramsen, Romualdas Smičius, Claus Bus, Jørgen Kjems, Joachim W. Engels · 2007 · Bioorganic & Medicinal Chemistry
- Synthesis, Structure, and Biological Activity of Dumbbell-Shaped Nanocircular RNAs for RNA InterferenceNaoko Abe, Hiroshi Abe, Chisato Nagai, Mitsuru Harada, Hiroto Hatakeyama, Hideyoshi Harashima, Takahito Ohshiro, Mizuki Nishihara, Kazuhiro Furukawa, Mizuo Maeda et al. · 2011 · Bioconjugate Chemistry
- Intracellular stability of 2′-OMe-4′-thioribonucleoside modified siRNA leads to long-term RNAi effectMayumi M. Takahashi, Chisato Nagai, Hiroto Hatakeyama, Noriaki Minakawa, Hideyoshi Harashima, Akira Matsuda · 2012 · Nucleic Acids Research
- Study of Modification Pattern–RNAi Activity Relationships by Using siRNAs Modified with 4′‐ThioribonucleosidesShuichi Hoshika, Noriaki Minakawa, Aki Shionoya, Keiko Imada, Naoki Ogawa, Akira Matsuda · 2007 · ChemBioChem
- Naked siLNA-Mediated Gene Silencing of Lung Bronchoepithelium EGFP Expression After Intravenous AdministrationSys Zoffmann Glud, Jesper B. Bramsen, Frederik Dagnæs‐Hansen, Jesper Wengel, Kenneth Alan Howard, Jens Randel Nyengaard, Jørgen Kjems · 2009 · Oligonucleotides
- RNAse A‐like enzymes in serum inhibit the anti‐neoplastic activity of siRNA targeting polo‐like kinase 1Jörg Haupenthal, Christina Baehr, Stefan Zeuzem, Albrecht Piiper · 2007 · International Journal of Cancer
- Determinants of Cytokine Induction by Small Interfering RNA in Human Peripheral Blood Mononuclear CellsMaryam Zamanian-Daryoush, João Trindade Marques, Michael Paul Gantier, Mark A. Behlke, Matthias John, Patricia A. Rayman, James Harold Finke, Bryan R.G. Williams · 2008 · Journal of Interferon & Cytokine Research
- Comprehensive analysis of sequence-specific stability of siRNAJunmei Hong, Yuanyu Huang, Jun Li, Yi Fan, Jie Zheng, Huang Huang, Na Wei, Yongqiang Shan, Mingrui An, Hongyan Zhang et al. · 2010 · The FASEB Journal
- RNA-based therapiesIrena Melnikova · 2007 · Nature Reviews Drug Discovery
- Structural Characterization and Biological Evaluation of Small Interfering RNAs Containing Cyclohexenyl NucleosidesKoen Nauwelaerts, Michael Fisher, Matheus Froeyen, Eveline Lescrinier, Arthur A. Van Aerschot, Xu D, Robert K. DeLong, Hyumin Kang, Rudolph L. Juliano, Piet A. Herdewijn · 2007 · Journal of the American Chemical Society
- Synthesis, Gene Silencing, and Molecular Modeling Studies of 4′-C-Aminomethyl-2′-O-methyl Modified Small Interfering RNAsKiran R. Gore, Ganesh N. Nawale, S. Harikrishna, Vinita G. Chittoor-Vinod, Sushil Kumar Pandey, Claudia Höbartner, Swati Patankar, Pushpangadan Indira Pradeepkumar · 2012 · The Journal of Organic Chemistry
- Atelocollagen-mediated Systemic Delivery Prevents Immunostimulatory Adverse Effects of siRNA in MammalsShinichiro Inaba, Shunji Nagahara, Naoki Makita, Yuzo Tarumi, Takuji Ishimoto, Seiichi Matsuo, Kenji Kadomatsu, Yoshifumi Takei · 2011 · Molecular Therapy
- The effects of thiophosphate substitutions on native siRNA gene silencingZheng-Yin Li, Haibo Mao, Deborah A. Kallick, David G. Gorenstein · 2005 · Biochemical and Biophysical Research Communications
- Biological effects of hexitol and altritol-modified siRNAs targeting B-RafMICHAEL S. FISHER, Mikhail Abramov, Arthur A. Van Aerschot, Jef Rozenski, Vidula Dixit, Rudy L. Juliano, Piet A. Herdewijn · 2009 · European Journal of Pharmacology
- Modified siRNA Structure With a Single Nucleotide Bulge Overcomes Conventional siRNA-mediated Off-target SilencingPooja Dua, Jae Wook Yoo, Soyoun Kim, Dong-ki Lee · 2011 · Molecular Therapy
- Chemically modified siRNA prolonged RNA interference in renal diseaseYoshitsugu Takabatake, Yoshitaka Isaka, Masayuki Mizui, Hiroshi Kawachi, Shiro Takahara, Enyu Imai · 2007 · Biochemical and Biophysical Research Communications
- Comprehensive evaluation of canonical versus Dicer-substrate siRNA in vitro and in vivoDonald J. Foster, Scott A. Barros, Rick Duncan, Sarfraz Shaikh, William L. Cantley, Amy Dell, Elena Bulgakova, Jonathan O′Shea, Nate Taneja, Satya Kuchimanchi et al. · 2012 · RNA
- Both Strands of siRNA Have Potential to Guide Posttranscriptional Gene Silencing in Mammalian CellsJunxia Wei, Jie Yang, Jifeng Sun, Lintao Jia, Yong Zhang, Huizhong Zhang, Xia Li, Yan–Ling Meng, Li-Bo Yao, Angang Yang · 2009 · PLoS ONE
- Fully 2′‐Deoxy‐2′‐Fluoro Substituted Nucleic Acids Induce RNA Interference in Mammalian Cell CultureRichard Blidner, Robert P. Hammer, Mandi J. Lopez, SANDRA O. ROBINSON, W. Todd Monroe · 2007 · Chemical Biology & Drug Design
- Erratum: RNA-based therapiesIrena Melnikova · 2008 · Nature Reviews Drug Discovery
- Stability of 3′ double nucleotide overhangs that model the 3′ ends of siRNAAMANDA S. O’TOOLE, STACY MILLER, Martin J. Serra · 2005 · RNA
- siRNA binding proteins of microglial cells: PKR is an unanticipated ligandZhiren Zhang, Toni Weinschenk, Ke‐Tai Guo, Hermann J. Schluesener · 2005 · Journal of Cellular Biochemistry
- Deciphering the Code of Innate Immunity Recognition of siRNAsMouldy Sioud · 2008 · Methods in molecular biology
- Predicting siRNA potency with random forests and support vector machinesLiangjiang Wang, Caiyan Huang, Jack Y. Yang · 2010 · BMC Genomics
- Sequences derived from self-RNA containing certain natural modifications act as suppressors of RNA-mediated inflammatory immune responsesSibylle Tluk, Marion Jurk, Alexandra Forsbach, Risini D. Weeratna, Ulrike Samulowitz, ARTHUR M. KRIEG, Stefan Bauer, J. Vollmer · 2009 · International Immunology
- Synthesis and biological activity of phosphonoacetate- and thiophosphonoacetate-modified 2′-O-methyl oligoribonucleotidesRichard Threlfall, Adrián Gabriel Torres, Angelika A. Krivenko, Michael John Gait, Marvin H. Caruthers · 2011 · Organic & Biomolecular Chemistry
- Small Interfering RNAs Induce Macrophage Migration Inhibitory Factor Production and Proliferation in Breast Cancer Cells via a Double-Stranded RNA-Dependent Protein Kinase-Dependent MechanismMichelle E. Armstrong, Michael Paul Gantier, Lili Li, Wen Yuan Chung, Amanda H McCann, John Andrew Baugh, Seamas C. Donnelly · 2008 · The Journal of Immunology
- Antisense oligonuclotides with oxetane-constrained cytidine enhance heteroduplex stability, and elicit satisfactory RNase H response as well as showing improved resistance to both exo and endonucleasesElectronic supplementary information (ESI) available: RNA cleavage kinetics. See http://www.rsc.org/suppdata/ob/b2/b210163g/Pushpangadan Indira Pradeepkumar, Nariman V. Amirkhanov, JYOTI B. CHATTOPADHYAYA · 2002 · Organic & Biomolecular Chemistry
- Comparing 2-nt 3' overhangs against blunt-ended siRNAs: a systems biology based studyPreetam Ghosh, Robert Dullea, James E Fischer, Tom Turi, Ronald W. Sarver, Chaoyang Zhang, Kalyan Basu, Sajal Kumar Das, Bradley W. Poland · 2009 · BMC Genomics
- Solid-Phase Synthesis of Modified RNAs Containing Amide-Linked Oligoribonucleosides at Their 3′-End and Their Application to siRNAReiko Iwase, Takaaki Toyama, Kengo Nishimori · 2007 · Nucleosides Nucleotides & Nucleic Acids
- Minimizing off-target effects by using diced siRNAs for RNA interference.Jason W. Myers, Jen‐Tsan Chi, Delquin Gong, Marci E. Schaner, Patrick O. Brown, James E. Ferrell · 2006 · Europe PMC (PubMed Central)
- Is RNAi Dead?Arthur Μ. Krieg · 2011 · Molecular Therapy
- Antisense—down, but not outCarol Potera · 2007 · Nature Biotechnology
- Differential repression of human and mouse TERT genes during cell differentiationShuwen Wang, Yuanjun Zhao, Chunguang Hu, Jiyue Zhu · 2009 · Nucleic Acids Research
- Rb/E2F1 Regulates the Innate Immune Receptor Toll-Like Receptor 3 in Epithelial CellsManabu Taura, Mary Ann Suico, Kosuke Koyama, Kensei Komatsu, Rui Miyakita, Chizuru Matsumoto, Eriko Kudo, Ryusho Kariya, Hiroki Goto, Shunsuke Kitajima et al. · 2012 · Molecular and Cellular Biology
- Involvement of Activation of PKR in HBx-siRNA-Mediated Innate Immune Effects on HBV InhibitionQiuju Han, Cai Zhang, Jian Zhang, Zhigang Tian · 2011 · PLoS ONE
- Unique Gene‐Silencing and Structural Properties of 2′‐Fluoro‐Modified siRNAsMuthiah Manoharan, Akin Akinc, Rajendra K. Pandey, June Qin, Philipp Hadwiger, Matthias John, Kathy Mills, Klaus Charissé, Martin A. Maier, Lubomir V. Nechev et al. · 2011 · Angewandte Chemie
- Self-splicing of a group I intron reveals partitioning of native and misfolded RNA populations in yeastScott A. Jackson, Sujatha P. Koduvayur, Sarah A. Woodson · 2006 · RNA
- RNA interference by 2′,5′-linked nucleic acid duplexes in mammalian cellsThazha P. Prakash, Bryan A. Kraynack, Brenda F. Baker, Eric E. Swayze, Balkrishen Bhat · 2006 · Bioorganic & Medicinal Chemistry Letters
- Functionally Enhanced siRNA Targeting TNFα Attenuates DSS-induced Colitis and TLR-mediated Immunostimulation in MiceSandra M. Ocampo, Carolina Romero, Anna Maria Aviñó, Juan F. Burgueño, Miguel Angel Gassull, Jordi Bermúdez, Ramón Eritja, Ester Fernández, Jose Carlos Perales · 2011 · Molecular Therapy
- RNAi momentum fizzles as pharma shifts prioritiesCharles Schmidt · 2011 · Nature Biotechnology
- Approximate Bayesian feature selection on a large meta-dataset offers novel insights on factors that effect siRNA potencyJochen W. Klingelhoefer, Loukas Moutsianas, Chris C. Holmes · 2009 · Bioinformatics
- 2'- O -Methyl–Modified Anti- MDR1 Fork-siRNA Duplexes Exhibiting High Nuclease Resistance and Prolonged Silencing ActivityNatalya S. Petrova, Mariya I. Meschaninova, Alya G. Venyaminova, Зенкова Марина Аркадьевна, Valentin V. Vlassov, Elena L. Chernolovskaya · 2010 · Oligonucleotides
- Immunostimulatory Potential of Silencing RNAs Can Be Mediated by a Non-Uridine-Rich Toll-Like Receptor 7 MotifMarion Jurk, Ghania Chikh, Bettina Schulte, Andrea Kritzler, Denise Richardt‐Pargmann, Catherine Lampron, Rachel Luu, Arthur Μ. Krieg, Alain P. Vicari, Jörg Vollmer · 2011 · Nucleic Acid Therapeutics
- The road to therapeutic RNA interference (RNAi): Tackling the 800 pound siRNA delivery gorilla.Bryan R. Meade, Steven F. Dowdy · 2009 · PubMed
- Increased potency and longevity of gene silencing using validated Dicer substrates.Eli Hefner, Kay H. Clark, C Whitman, Mark A. Behlke, Scott D. Rose, A. S. Peek, T Rubio · 2008 · PubMed Central
- Drug giants turn their backs on RNA interferenceHeidi K. Ledford · 2010 · Nature
- Silencing Gene Expression with Dicer-Generated siRNA PoolsJason W. Myers, James E. Ferrell · 2005 · Humana Press eBooks
- FDA approves fomivirsen, famciclovir, and Thalidomide. Food and Drug Administration.Liz Highleyman · 1998 · PubMed
- Competition Between siRNA Duplexes: Impact of RNA-Induced Silencing Complex Loading Efficiency and Comparison Between Conventional-21 bp and Dicer-Substrate siRNAsMarcel Tanudji, Dorothy A. Machalek, Greg M. Arndt, Laurent P. Rivory · 2009 · Oligonucleotides
- Adenosine Modification May Be Preferred for Reducing siRNA Immune StimulationRaymond V. Fucini, Henry J. Haringsma, Patricia Deng, W. Michael Flanagan, Aarron T. Willingham · 2012 · Nucleic Acid Therapeutics
- Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7V. Hornung, M. Guenthner-Biller, C. Bourquin, A. Ablasser, M. Schlee, S. Uematsu, A. Noronha, M. Manoharan, Shizuo Akira, A. de Fougerolles et al. · 2005
- Competition potency of siRNA is specified by the 5′-half sequence of the guide strandJae Wook Yoo, Soyoun Kim, Dong-ki Lee · 2007 · Biochemical and Biophysical Research Communications
- Immunostimulatory properties and antiviral activity of modified HBV-specific siRNAsDuckhyang Shin, Soo In Kim, Mahnhoon Park, Meehyein Kim · 2007 · Biochemical and Biophysical Research Communications
- Degradation of hammerhead ribozymes by human ribonucleasesLirong Qiu, Andre Luis Moreira, Gilla Kaplan, Ruth Levitz, J.-Y. Wang, Chen Xu, Karl Drlica · 1998 · Molecular and General Genetics MGG
- A systematic analysis of the silencing effects of an active siRNA at all single-nucleotide mismatched target sitesQiu Du · 2005 · Nucleic Acids Research
- Synthesis and Biological Activity of Phosphonocarboxylate DNAChristina M. Yamada, Douglas J. Dellinger, Marvin H. Caruthers · 2007 · Nucleosides Nucleotides & Nucleic Acids
- 21. Efficient In Vivo Delivery of siRNA to Liver by Conjugation of Alpha-Tocopherol2008 · Molecular Therapy
- In vivo screening of modified siRNAs for non-specific antiviral effect in a small fish model: number and localization in the strands are importantBrian Dall Schyth, Jesper B. Bramsen, Malgorzata Maria Pakula, Sekar Larashati, Jørgen Kjems, Jesper Wengel, Niels Lorenzen · 2012 · Nucleic Acids Research
- Contributions of 3′-overhang to the dissociation of small interfering RNAs from the PAZ domain: Molecular dynamics simulation studyHui Sun Lee, Soo Nam Lee, Chul Hyun Joo, Heuiran Lee, Hansaem Lee, Seung Yong Yoon, Yoo Kyum Kim, Han Choe · 2006 · Journal of Molecular Graphics and Modelling
- High-Dose siRNAs Upregulate Mouse Eri-1 at both Transcription and Posttranscription LevelsYingnan Bian, Wei Lan Zhou, Yingchun Zhao, Xiaoping Li, Wei Geng, Ruixin Hao, Qing Kun Yang, Weida Huang · 2011 · PLoS ONE
- Stimulation of the XPB ATP-dependent helicase by the beta subunit of TFIIEYin Chun Lin · 2005 · Nucleic Acids Research
- Structural and Binding Study of Modified siRNAs with the Argonaute 2 PAZ Domain by NMR SpectroscopyMohitosh Maiti, Koen Nauwelaerts, Eveline Lescrinier, Piet A. Herdewijn · 2011 · Chemistry - A European Journal
- Informatics Approach to the Rational Design of siRNA LibrariesJerry Osagie Ebalunode, Charles Jagun, Weifan Zheng · 2010 · Methods in molecular biology
- RNA interference induced by siRNAs modified with 4′-thioribonucleosidesShuichi Hoshika, Noriaki Minakawa, Akira Matsuda · 2005 · Nucleic Acids Symposium Series
- Immunostimulatory Potential of Silencing RNAs Can Be Mediated by a Non-Uridine-Rich Toll-Like Receptor 7 MotifMarion Jurk, Ghania Chikh, Bettina Schulte, Andrea Kritzler, Denise Richardt‐Pargmann, Catherine Lampron, Rachel Luu, Arthur Μ. Krieg, Alain P. Vicari, Jörg Vollmer · 2011 · Oligonucleotides