Development of Therapeutic-Grade Small Interfering RNAs by Chemical Engineering

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5'-Triphosphate RNA Is the Ligand for RIG-I

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Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs

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Rational siRNA design for RNA interference

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A microRNA in a Multiple-Turnover RNAi Enzyme Complex

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Quantitative Expression of Toll-Like Receptor 1–10 mRNA in Cellular Subsets of Human Peripheral Blood Mononuclear Cells and Sensitivity to CpG Oligodeoxynucleotides

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Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs

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Specificity of microRNA target selection in translational repressionPreprint

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LNA-mediated microRNA silencing in non-human primates

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Single-stranded antisense siRNAs guide target RNA cleavage in RNAi.

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Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate

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Activation of the interferon system by short-interfering RNAs

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RNAi-mediated gene silencing in non-human primates

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siRNAs can function as miRNAsPreprint

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Argonaute2, a Link Between Genetic and Biochemical Analyses of RNAi

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Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA

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Differential Alteration in Intestinal Epithelial Cell Expression of Toll-Like Receptor 3 (TLR3) and TLR4 in Inflammatory Bowel Disease

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Sequence-specific potent induction of IFN-α by short interfering RNA in plasmacytoid dendritic cells through TLR7

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Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs

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MicroRNAs direct rapid deadenylation of mRNA

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ATP Requirements and Small Interfering RNA Structure in the RNA Interference Pathway

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Antisense technologies

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Passenger-Strand Cleavage Facilitates Assembly of siRNA into Ago2-Containing RNAi Enzyme Complexes

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Widespread siRNA “off-target” transcript silencing mediated by seed region sequence complementarity

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Perspective: machines for RNAiPreprint

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Sequence- and target-independent angiogenesis suppression by siRNA via TLR3

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3′ UTR seed matches, but not overall identity, are associated with RNAi off-targets

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RNA-Based Therapeutics: Current Progress and Future Prospects

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Synthetic dsRNA Dicer substrates enhance RNAi potency and efficacy

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Exon skipping and dystrophin restoration in patients with Duchenne muscular dystrophy after systemic phosphorodiamidate morpholino oligomer treatment: an open-label, phase 2, dose-escalation study

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siRNA function in RNAi: A chemical modification analysis

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Guidelines for the selection of highly effective siRNA sequences for mammalian and chick RNA interference

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Position-specific chemical modification of siRNAs reduces “off-target” transcript silencing

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Local Dystrophin Restoration with Antisense Oligonucleotide PRO051

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Evaluation of 2‘-modified oligonucleotides containing 2‘-deoxy gaps as antisense inhibitors of gene expression

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Current prospects for RNA interference-based therapies

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Structural basis for overhang-specific small interfering RNA recognition by the PAZ domain

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The ups and downs of nucleic acid duplex stability: structure-stability studies on chemically-modified DNA:RNA duplexes

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Progress towards in Vivo Use of siRNAs

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mda-5 : An interferon-inducible putative RNA helicase with double-stranded RNA-dependent ATPase activity and melanoma growth-suppressive properties

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Stability of Endogenous and Added RNA in Blood Specimens, Serum, and Plasma

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Structural variations and stabilising modifications of synthetic siRNAs in mammalian cells

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The Promise of MicroRNA Replacement Therapy

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LNA: a versatile tool for therapeutics and genomics

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A conserved siRNA-degrading RNase negatively regulates RNA interference in C. elegans

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In vivo activity of nuclease-resistant siRNAs

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Design of Noninflammatory Synthetic siRNA Mediating Potent Gene Silencing in Vivo

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Nucleation, propagation and cleavage of target RNAs in Ago silencing complexes

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Transfection of small RNAs globally perturbs gene regulation by endogenous microRNAs

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Tolerance for mutations and chemical modifications in a siRNA

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RNA Interference in Mammalian Cells by Chemically-Modified RNA

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Structure of the guide-strand-containing argonaute silencing complex

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Off-target effects by siRNA can induce toxic phenotype

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Interactions between Double-Stranded RNA Regulators and the Protein Kinase DAI

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Nonself RNA-Sensing Mechanism of RIG-I Helicase and Activation of Antiviral Immune Responses

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Sequence, Chemical, and Structural Variation of Small Interfering RNAs and Short Hairpin RNAs and the Effect on Mammalian Gene Silencing

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Antisense oligonucleotides containing locked nucleic acid improve potency but cause significant hepatotoxicity in animals

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Chemical Modification of siRNAs for In Vivo Use

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Fully 2‘-Modified Oligonucleotide Duplexes with Improved in Vitro Potency and Stability Compared to Unmodified Small Interfering RNA

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Current progress of siRNA/shRNA therapeutics in clinical trials

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Synthetic shRNAs as potent RNAi triggers

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An algorithm for selection of functional siRNA sequences

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A human, ATP-independent, RISC assembly machine fueled by pre-miRNAPreprint

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Induction of Inflammatory Cytokines and Interferon Responses by Double-stranded and Single-stranded siRNAs is Sequence-dependent and Requires Endosomal Localization

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RISC is a 5′ phosphomonoester-producing RNA endonucleasePreprint

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Functional Anatomy of a dsRNA Trigger

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Comparison of antisense oligonucleotides and siRNAs in cell culture and in vivo

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Cleavage of the siRNA passenger strand during RISC assembly in human cells

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RNAi in Human Cells

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Design of a genome-wide siRNA library using an artificial neural network

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A structural basis for discriminating between self and nonself double-stranded RNAs in mammalian cells

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siRNA-mediated off-target gene silencing triggered by a 7 nt complementation

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Nucleic acid 3′-end recognition by the Argonaute2 PAZ domain

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Chemical modification of siRNAs to improve serum stability without loss of efficacy

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2′-O-methyl-modified RNAs Act as TLR7 Antagonists

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A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity

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Target mRNA abundance dilutes microRNA and siRNA activity

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An accurate and interpretable model for siRNA efficacy prediction

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Induction of the interferon response by siRNA is cell type– and duplex length–dependent

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Multi-target RNA interference: A disruptive next-generation strategy for precision treatment of rheumatoid arthritis

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Intracellular Reassociation of RNA–DNA Hybrids that Activates RNAi in HIV-Infected Cells

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Targeted SMN Exon Skipping: A Useful Control to Assess In Vitro and In Vivo Splice-Switching Studies

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RNA Nanotechnology

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RNA‐Based Therapeutics: Cutting‐Edge Advances in Clinical Research

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RNA Nanostructures in Physiological Solutions: Multiscale Modeling and Applications

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The chemistry and biology of natural ribomimetics and related compounds

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Nanotechnology Lighting the Way for Gene Therapy in Ophthalmopathy: From Opportunities toward Applications

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Bioengineered RNA Therapy in Patient-Derived Organoids and Xenograft Mouse Models

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Development of Long Asymmetric siRNA Structure for Target Gene Silencing and Immune Stimulation in Mammalian Cells

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Molecular Mechanisms of Innate Immune Sensing of Exogenous RNAs

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Small RNA-mediated prevention, diagnosis and therapies of cancer

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Delivery of Cancer Nanotherapeutics

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Exploring the Dark Matter of the Human Genome Using Oligonucleotide-Based Molecules

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RNAi Validation of Pancreatic Cancer Antigens Identified by Cell Surface Proteomics

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Mechanisms of Oligonucleotide Actions

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Synthetic Technology of Noncoding RNAs Used in Bone Disease Research and Therapeutics

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Nucleic acid-based immune checkpoint blockade: Progress and potential

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Engineering Small Interfering RNAs by Strategic Chemical Modification

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Chemical Modification of Small Interfering RNA

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Therapeutic potential of chemically modified si RNA : Recent trends

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