The DOI matches its Crossref record; 134 of the 134 references it cites were found in a registry or an index.
Micronuclei in genotoxicity assessment: from genetics to epigenetics and beyond
Open accessAbstract
Micronuclei (MN) are extra-nuclear bodies that contain damaged chromosome fragments and/or whole chromosomes that were not incorporated into the nucleus after cell division. MN can be induced by defects in the cell repair machinery and accumulation of DNA damages and chromosomal aberrations. A variety of genotoxic agents may induce MN formation leading to cell death, genomic instability, or cancer development. In this review, the genetic and epigenetic mechanisms of MN formation after various clastogenic and aneugenic effects on cell division and cell cycle are described. The knowledge accumulated in literature on cytotoxicity of various genotoxins is precisely reflected and individual sensitivity to MN formation due to single gene polymorphisms is discussed. The importance of rapid MN scoring with respect to the cytokinesis-block micronucleus assay is also evaluated.
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Cites
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Cited by
Zhang, C., Chen, L., Peng, D., Jiang, A., He, Y., Zeng, Y., Xie, C., Zhou, H., Luo, X., Liu, H., et al. (2020) · Molecular Cell · doi:10.1016/j.molcel.2020.06.017 · Cited by 331
Kesari, K. K., Agarwal, A., & Henkel, R. (2018) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-018-0431-1 · Cited by 294
Metformin: prevention of genomic instability and cancer: a review
Najafi, M., Cheki, M., Rezapoor, S., Geraily, G., Motevaseli, E., Carnovale, C., Clementi, E., & Shirazi, A. (2018) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2018.01.007 · Cited by 75
Kim, S., Han, D., Ryu, J., Kim, K., & Kim, Y. H. (2021) · Environmental Research · doi:10.1016/j.envres.2021.111784 · Cited by 37
La Maestra, S., Micale, R. T., Ferretti, M., Izzotti, A., & Gaggero, L. (2020) · Scientific Reports · doi:10.1038/s41598-020-65620-x · Cited by 14
Metadata
- Authors
- Luzhna, L., Kathiria, P., & Kovalchuk, O.
- Venue
- Frontiers in Genetics
- Publisher
- Frontiers Media SA
- Published
- 2013
- Volume
- 4
- Pages
- 131-131
- ISSN
- 1664-8021 (ISSN-L)
- OpenAlex
- W2103013707
- Cited by
- 450
- References
- 134
- FWCI
- 3.93
- Type
- journal article
- Language
- en
- Open access
- gold
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- Luzhna, L., Kathiria, P., & Kovalchuk, O. (2013). Micronuclei in genotoxicity assessment: from genetics to epigenetics and beyond. Frontiers in Genetics. https://doi.org/10.3389/fgene.2013.00131
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
