The DOI matches its Crossref record; 214 of the 214 references it cites were found in a registry or an index.
Drosophila melanogaster: A Model Organism to Study Cancer
Open accessAbstract
Cancer is a multistep disease driven by the activation of specific oncogenic pathways concomitantly with the suppression of tumor suppressor genes that act as sentinels to control physiological growth. The conservation of most of these signaling pathways in Drosophila, and the ability to easily manipulate them genetically, has made the fruit fly a useful model organism to study cancer biology. In this review we outlined the basic mechanisms and signaling pathways conserved between humans and flies responsible of inducing uncontrolled growth and cancer development. Second, we described classic and novel Drosophila models used to study different cancers, with the objective to discuss their strengths and limitations on their use to understand growth cell autonomously and within organs, and their use for drug screens aimed at the discover of therapeutic approaches.
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Cites
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Cited by
RasV12; scrib−/− Tumors: A Cooperative Oncogenesis Model Fueled by Tumor/Host Interactions
Dillard, C., Reis, J. G. T., & Rusten, T. E. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22168873 · Cited by 34
Shared enhancer gene regulatory networks between wound and oncogenic programs
Floc'hlay, S., Balaji, R., Stanković, D., Christiaens, V. M., Bravo González-Blas, C., De Winter, S., Hulselmans, G. J., De Waegeneer, M., Quan, X., Koldere, D., et al. (2023) · eLife · doi:10.7554/elife.81173 · Cited by 27
Metadata
- Authors
- Mirzoyan, Z., Sollazzo, M., Allocca, M., Valenza, A. M., Grifoni, D., & Bellosta, P.
- Venue
- Frontiers in Genetics
- Publisher
- Frontiers Media SA
- Published
- 2019-03-01
- Volume
- 10
- Pages
- 51-51
- ISSN
- 1664-8021 (ISSN-L)
- OpenAlex
- W2919287201
- Cited by
- 317
- References
- 214
- FWCI
- 8.67
- Type
- journal article
- Language
- en
- Open access
- gold
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- Mirzoyan, Z., Sollazzo, M., Allocca, M., Valenza, A. M., Grifoni, D., & Bellosta, P. (2019). Drosophila melanogaster: A Model Organism to Study Cancer. Frontiers in Genetics. https://doi.org/10.3389/fgene.2019.00051
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
