News and Views on STAT3 Psychopathology
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OPINION article Front. Genet., 26 November 2021 | https://doi.org/10.3389/fgene.2021.791201
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Expression of miR-124, miR-532-5p, and miR-9-5p alters in tissues from depression patients or animal models, activating STAT3 and mediating disruption of neuronal differentiation and proliferation in depression.
“the expression of miR-124, miR-532-5p, and miR-9-5p alters in tissues from depression patients/animal models, activating signal transducer and activator of transcription 3 (STAT3) and mediating the disruption of neuronal differentiation and proliferation in depression.259–262”
From Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential (2023) · cites this paper as [261]
The Introduction discusses STAT3 and emotional behavior in mice, and the Discussion addresses biomarkers in depression, but neither links the named miRNAs to STAT3. Searches for miR-124, miR-532-5p, miR-9-5p, and neuronal differentiation or proliferation found no passage addressing the claimed mechanism. Our copy has no page numbers for these sections. (LLM, conf=0.76)
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Cites
A molecular atlas of cell types and zonation in the brain vasculature
Vanlandewijck, M., He, L., Mäe, M. A., Andrae, J., Ando, K., Del Gaudio, F., Nahar, K., Lebouvier, T., Laviña, B., Gouveia, L., et al. (2018) · Nature · doi:10.1038/nature25739 · Cited by 2,074 · see citing works
Varatharaj, A., Thomas, N., Ellul, M. A., Davies, N. W. S., Pollak, T. A., Tenorio, E. L., Sultan, M., Easton, A., Breen, G., Zandi, M., et al. (2020) · The Lancet Psychiatry · doi:10.1016/s2215-0366(20)30287-x · Cited by 1,246 · see citing works
Troyer, E. A., Kohn, J. N., & Hong, S. (2020) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2020.04.027 · Cited by 964 · see citing works
Biomarkers in Psychiatry: Concept, Definition, Types and Relevance to the Clinical Reality
García-Gutiérrez, M. S., Navarrete, F., Sala, F., Gasparyan, A., Austrich-Olivares, A., & Manzanares, J. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00432 · Cited by 331 · see citing works
STAT3 Hyper-IgE Syndrome—an Update and Unanswered Questions
Tsilifis, C., Freeman, A. F., & Gennery, A. R. (2021) · Journal of Clinical Immunology · doi:10.1007/s10875-021-01051-1 · Cited by 160 · see citing works
The Role of Biomarkers in Psychiatry.
Lozupone, M., la Montagna, M., D'Urso, F., Daniele, A., Greco, A., Seripa, D., Logroscino, G., Bellomo, A., & Panza, F. (2019) · Advances in Experimental Medicine and Biology · doi:10.1007/978-3-030-05542-4_7 · Cited by 49 · see citing works
Reisinger, S. N., Sideromenos, S., Horváth, O., Derdak, S. V., Cicvaric, A., Monje, F. J., Bilban, M., Häring, M., Glat, M. J., & Pollak, D. D. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-00904-2 · Cited by 23 · see citing works
The structure of first-cousin marriages in Brazil
Otto, P. A., Lemes, R. B., de Farias, A. A., Weller, M., Lima, S. O. A., Albino, V. A., Marques-Alves, Y. K., Pardono, E., Bocángel, M. A. P., & Santos, S. (2020) · Scientific Reports · doi:10.1038/s41598-020-72366-z · Cited by 8 · see citing works
Sadok, S. H., Borges-Medeiros, R. L., & de Oliveira, J. R. M. (2021) · Journal of Molecular Neuroscience · doi:10.1007/s12031-021-01904-9 · Cited by 1 · see citing works
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Yuan, M., Yang, B., Rothschild, G., Mann, J. J., Sanford, L. D., Tang, X., Huang, C., Wang, C., & Zhang, W. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01519-z · Cited by 246 · see citing works
Gomes, I. J. L., Pereira, C. C. S., Soares, M. L. C., Barbosa, A. C. P., Meira, A. C. R., de Barros, P. V. M., & de Oliveira, J. R. M. (2024) · Brazilian Journal of Health Review · doi:10.34119/bjhrv7n1-470
- Authors
- Sadok, S. H., Borges-Medeiros, R. L., Macêdo, P. V. B., de Oliveira, J. R. M., & High IgE Consortium
- Affiliations
- Universidade Federal de Pernambuco (BR)
- Venue
- Frontiers in Genetics
- Publisher
- Frontiers Media SA
- Published
- 2021-11-26
- Volume
- 12
- ISSN
- 1664-8021 (ISSN-L)
- PMC
- PMC8662990
- OpenAlex
- W3216214775
- Cited by
- 2
- References
- 9
- Citations by year
- 2024: 1 · 2023: 1
- FWCI
- 0.18
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Genetics (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Universidade Federal de Pernambuco
- Topics
- Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- STAT3, psychopathology, mental illness
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