An integrated pan-cancer analysis of PSAT1: A potential biomarker for survival and immunotherapy
Open accessAbstract
Phosphoserine aminotransferase 1 (PSAT1) may be an oncogene that plays an important role in various cancer types. However, there are still many gaps in the expression of PSAT1 gene and its biological impact in different types of tumors. Here, we performed an integrated pan-cancer analysis to explore the potential molecular mechanisms of PSAT1 in cancers. We found that most human tumors express higher levels of PSAT1 than normal tissues, and that higher PSAT1 expression is associated with worse prognosis in Lung adenocarcinoma (LUAD), Pan-kidney cohort (KIPAN) and breast invasive carcinoma (BRCA), etc. In BRCA cases, the prognosis of patients with altered PSAT1 was worse than that of patients without alteration. In addition, PSAT1 hypermethylation is associated with T cell dysfunction and shortened survival time in BRCA. The Gene Set Enrichment Analysis (GSEA) analysis showed that PSAT1 can be enriched into the classic signaling pathways of cancer such as mTORC1 signaling, MYC targets and JAK STAT3. Further analysis demonstrated that PSAT1 was enriched in immune related signaling pathways in LUAD and BRCA. The results of immunoassay showed that PSAT1 was associated with immune cell infiltration in multiple cancer species. Furthermore, expression of PSAT1 was correlated with both tumor mutational burden (TMB) and microsatellite instability (MSI) in BRCA. Additionally, a remarkable correlation was found between PSAT1 expression and TMB in LUAD, and the expression of PSAT1 was negatively correlated with the Tumor Immune Dysfunction and Exclusion (TIDE) value, suggesting a good effect of immunotherapy. Together, these data suggest that PSAT1 expression is associated with the clinical prognosis, DNA methylation, gene mutations, and immune cell infiltration, contributing to clarify the role of PSAT1 in tumorigenesis from a variety of perspectives. What's more, PSAT1 may be a new biomarker for survival and predicting the efficacy of immunotherapy for LUAD and BRCA.
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High expression of genes coding for these enzymes and their transcriptional regulators is strongly associated with shortened patient survival in different types of malignancies.
“The high expression of genes coding for all of these enzymes and their transcriptional regulators is strongly associated with a shortened patient survival in different types of malignancies [66,67,68,69,70,71,72,73,74].”
From 20-Hydroxyecdysone Confers Antioxidant and Antineoplastic Properties in Human Non-Small Cell Lung Cancer Cells (2023) · cites this paper as [70]
The up-regulation of glycolysis and one-carbon metabolism, and increased expression of corresponding enzymes, are usually observed in various neoplasms and are associated with metastasis, resistance to therapy, and poor prognosis.
“The up-regulation of glycolysis and one-carbon metabolism, and the increased expression of genes coding for corresponding enzymes, are usually observed in various neoplasms and are associated with metastasis, resistance to therapy, and poor prognosis.”
From 20-Hydroxyecdysone Confers Antioxidant and Antineoplastic Properties in Human Non-Small Cell Lung Cancer Cells (2023) · cites this paper as [70]
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1 retracted
Dai, J., Wei, R., Zhang, P., & Kong, B. (2019) · Journal of Translational Medicine · doi:10.1186/s12967-019-1932-1 · Cited by 58 · see citing works
RetractedCerami, E., Gao, J., Dogrusoz, U., Gross, B. E., Sumer, S. O., Aksoy, B. A., Jacobsen, A., Byrne, C. J., Heuer, M. L., Larsson, E., et al. (2012) · Cancer Discovery · doi:10.1158/2159-8290.cd-12-0095 · Cited by 17,455 · see citing works
Tissue-based map of the human proteome
Uhlén, M., Fagerberg, L., Hallström, B. M., Lindskog, C., Oksvold, P., Mardinoglu, A., Sivertsson, Å., Kampf, C., Sjöstedt, E., Asplund, A., et al. (2015) · Science · doi:10.1126/science.1260419 · Cited by 15,286 · see citing works
Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal
Gao, J., Aksoy, B. A., Dogrusoz, U., Dresdner, G., Gross, B., Sumer, S. O., Sun, Y., Jacobsen, A., Sinha, R., Larsson, E., et al. (2013) · Science Signaling · doi:10.1126/scisignal.2004088 · Cited by 15,160 · see citing works
Signatures of T cell dysfunction and exclusion predict cancer immunotherapy response
Jiang, P., Gu, S., Pan, D., Fu, J., Sahu, A., Hu, X., Li, Z., Traugh, N., Bu, X., Li, B., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0136-1 · Cited by 5,179 · see citing works
ReactomePA: an R/Bioconductor package for reactome pathway analysis and visualization
Yu, G., & He, Q. (2015) · Molecular BioSystems · doi:10.1039/c5mb00663e · Cited by 1,941 · see citing works
Turning foes to friends: targeting cancer-associated fibroblasts
Chen, X., & Song, E. (2018) · Nature Reviews Drug Discovery · doi:10.1038/s41573-018-0004-1 · Cited by 1,884 · see citing works
Self-citationLandscape of Microsatellite Instability Across 39 Cancer Types
Bonneville, R., Krook, M. A., Kautto, E. A., Miya, J., Wing, M. R., Chen, H., Reeser, J. W., Yu, L., & Roychowdhury, S. (2017) · JCO Precision Oncology · doi:10.1200/po.17.00073 · Cited by 1,474 · see citing works
Protter: interactive protein feature visualization and integration with experimental proteomic data
Omasits, U., Ahrens, C. H., Müller, S., & Wollscheid, B. (2013) · Bioinformatics · doi:10.1093/bioinformatics/btt607 · Cited by 1,352 · see citing works
The role of m6A, m5C and Ψ RNA modifications in cancer: Novel therapeutic opportunities
Nombela, P., Miguel‐López, B., & Blanco, S. (2021) · Molecular Cancer · doi:10.1186/s12943-020-01263-w · Cited by 494 · see citing works
Open Targets Platform: new developments and updates two years on
Carvalho‐Silva, D., Pierleoni, A., Pignatelli, M., Ong, C. K., Fumis, L., Karamanis, N., Carmona, M., Faulconbridge, A., Hercules, A., McAuley, E., et al. (2018) · Nucleic Acids Research · doi:10.1093/nar/gky1133 · Cited by 449 · see citing works
LKB1 loss links serine metabolism to DNA methylation and tumorigenesis
Kottakis, F., Nicolay, B. N., Roumane, A., Karnik, R., Gu, H., Nagle, J. M., Boukhali, M., Hayward, M. C., Li, Y. Y., Chen, T., et al. (2016) · Nature · doi:10.1038/nature20132 · Cited by 348 · see citing works
Enhanced serine production by bone metastatic breast cancer cells stimulates osteoclastogenesis
Pollari, S., Käkönen, S.-M., Edgren, H., Wolf, M., Kohonen, P., Sara, H., Guise, T., Nees, M., & Kallioniemi, O. (2011) · Breast Cancer Research and Treatment · doi:10.1007/s10549-010-0848-5 · Cited by 269 · see citing works
Immune Infiltration in Human Cancer: Prognostic Significance and Disease Control
Fridman, W. H., Galon, J., Dieu‐Nosjean, M., Cremer, I., Fisson, S., Damotte, D., Pagès, F., Tartour, É., & Sautès‐Fridman, C. (2010) · Current topics in microbiology and immunology · doi:10.1007/82_2010_46 · Cited by 258 · see citing works
PERK is a critical metabolic hub for immunosuppressive function in macrophages
Raines, L. N., Zhao, H., Wang, Y., Chen, H.-Y., Gallart‐Ayala, H., Hsueh, P., Cao, W., Koh, Y., Almonte-Loya, A., Liu, P.-S., et al. (2022) · Nature Immunology · doi:10.1038/s41590-022-01145-x · Cited by 243 · see citing works
Vié, N., Copois, V., Mollévi, C., Denis, V., Bec, N., Robert, B., Fraslon, C., Conseiller, E., Molina, F., Larroque, C., et al. (2008) · Molecular Cancer · doi:10.1186/1476-4598-7-14 · Cited by 201 · see citing works
Remón, J., Passiglia, F., Ahn, M., Barlési, F., Forde, P. M., Garon, E. B., Gettinger, S. N., Goldberg, S. B., Herbst, R. S., Horn, L., et al. (2020) · Journal of Thoracic Oncology · doi:10.1016/j.jtho.2020.03.006 · Cited by 168 · see citing works
The Role of Immune Escape and Immune Cell Infiltration in Breast Cancer
Steven, A., & Seliger, B. (2018) · Breast Care · doi:10.1159/000486585 · Cited by 164 · see citing works
Gao, S., Ge, A., Xu, S., You, Z., Ning, S., Zhao, Y., & Pang, D. (2017) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-017-0648-4 · Cited by 148 · see citing works
Transient pseudo-isotachophoresis for sample concentration in capillary electrophoresis
Shihabi, Z. K. (2002) · Electrophoresis · doi:10.1002/1522-2683(200206)23:11 · Cited by 144 · see citing works
Cancer-associated fibroblasts: how do they contribute to metastasis?
Kwa, M. Q., Herum, K. M., & Brakebusch, C. (2019) · Clinical & Experimental Metastasis · doi:10.1007/s10585-019-09959-0 · Cited by 144 · see citing works
DNA methylation profiles of long- and short-term glioblastoma survivors
Shinawi, T., Hill, V. K., Krex, D., Schackert, G., Gentle, D., Morris, M. R., Wei, W., Cruickshank, G. S., Maher, E. R., & Latif, F. (2013) · Epigenetics · doi:10.4161/epi.23398 · Cited by 129 · see citing works
PSAT1 regulates cyclin D1 degradation and sustains proliferation of non‐small cell lung cancer cells
Yang, Y., Wu, J., Cai, J., He, Z., Yuan, J. X., Zhu, X., Li, Y., Li, M., & Guan, H. (2014) · International Journal of Cancer · doi:10.1002/ijc.29150 · Cited by 107 · see citing works
Men, C., Chai, H., Song, X., Li, Y., Du, H., & Ren, Q. (2017) · Journal of Gynecologic Oncology · doi:10.3802/jgo.2017.28.e83 · Cited by 84 · see citing works
Liu, B., Jia, Y., Cao, Y., Wu, S., Jiang, H., Sun, X., Ma, J., Yin, X., Mao, A., & Shang, M. (2016) · Cellular Physiology and Biochemistry · doi:10.1159/000445633 · Cited by 75 · see citing works
Self-citationMetcalf, S. A., Dougherty, S. M., Kruer, T. L., Hasan, N., Biyik‐Sit, R., Reynolds, L., & Clem, B. F. (2019) · Clinical & Experimental Metastasis · doi:10.1007/s10585-019-10000-7 · Cited by 66 · see citing works
Overexpression of PSAT1 promotes metastasis of lung adenocarcinoma by suppressing the IRF1-IFNγ axis
Chan, Y.-C., Chang, Y., Chuang, H.-H., Yang, Y., Lin, Y., Huang, M.-S., Hsiao, M., Yang, C., & Hua, K. (2020) · Oncogene · doi:10.1038/s41388-020-1160-4 · Cited by 58 · see citing works
Marchi, T. D., Timmermans, M. A. M., Sieuwerts, A. M., Smid, M., Look, M. P., Grebenchtchikov, N. I., Sweep, F. C. G. J., Smits, J. G., Magdolen, V., van Deurzen, C. H. M., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-02296-w · Cited by 49 · see citing works
Phosphoserine Aminotransferase, the Second Step-Catalyzing Enzyme for Serine Biosynthesis
Basurko, M.-J., Marche, M., Darriet, M., & CASSAIGNE, A. (1999) · IUBMB Life · doi:10.1080/713803557 · Cited by 48 · see citing works
Overexpression of PSAT1 regulated by G9A sustains cell proliferation in colorectal cancer
Wang, H., Cui, L., Li, D., Fan, M., Liu, Z., Liu, C., Pan, S., Zhang, L., Zhang, H., & Zhao, Y. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-0147-5 · Cited by 45 · see citing works
Self-citationQian, C., Xia, Y., Ren, Y., Yin, Y., & Deng, A. (2017) · Oncology Letters · doi:10.3892/ol.2017.7211 · Cited by 32 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Targeting serine-glycine-one-carbon metabolism as a vulnerability in cancers
Sun, W. Y., Liu, R., Gao, X., Lin, Z., Tang, H., Cui, H., & Zhao, E. (2023) · Biomarker Research · doi:10.1186/s40364-023-00487-4 · Cited by 82 · see citing works
Self-citationThe role of serine metabolism in lung cancer: From oncogenesis to tumor treatment
Zhou, X., Tian, C., Cao, Y., Zhao, M., & Wang, K. (2023) · Frontiers in Genetics · doi:10.3389/fgene.2022.1084609 · Cited by 30 · see citing works
Self-citationBrouwer, N. P. M., Webbink, L., Haddad, T. S., Rutgers, N., van Vliet, S., Wood, C. S., Jansen, P. W. T. C., Lafarge, M. W., de Wilt, J. H. W., Hugen, N., et al. (2023) · The Journal of Pathology · doi:10.1002/path.6196 · Cited by 28 · see citing works
Shuvalov, O., Kirdeeva, Y., Fefilova, E., Netsvetay, S., Zorin, M., Vlasova, Y., Fedorova, O., Daks, A., Parfenyev, S., & Barlev, N. (2023) · Metabolites · doi:10.3390/metabo13050656 · Cited by 21 · see citing works
Pouliquen, D., Gall‐Tros̆elj, K., & Anto, R. J. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15061612 · Cited by 20 · see citing works
Liu, Y., Xun, W., Zhao, T., Huang, M.-L., Sun, L., Wen, G., Kang, X., Wang, J., & Han, T. (2024) · Communications Biology · doi:10.1038/s42003-024-07051-2 · Cited by 19 · see citing works
Qassab, M. A., Chaarani, N., Hamou, A., Harb, R., Jradi, A., Zeineddine, M., Ghadieh, H. E., Khattar, Z. A., Azar, S., Kanaan, A., et al. (2026) · FASEB bioAdvances · doi:10.1096/fba.2025-00218 · Cited by 21 · see citing works
Liu, Y., Du, Z., Li, T., Zhang, J., Cheng, Y., Huang, J., Yang, J., Wen, L., Tian, M., Yang, M., et al. (2023) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2023.176162 · Cited by 14 · see citing works
Citarella, A., Besharat, Z. M., Coppola, L., Sabato, C., Autilio, T. M., Vicentini, E., Bimonte, V. M., Catanzaro, G., Pediconi, N., Fabi, A., et al. (2025) · Environmental Pollution · doi:10.1016/j.envpol.2025.126422 · Cited by 14 · see citing works
Sarad, K., Jankowska, U., Skupień-Rabian, B., Babler, A., Kramann, R., Dulak, J., & Jaźwa, A. (2024) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-024-05028-7 · Cited by 13 · see citing works
Serine metabolism in tumor progression and immunotherapy
Huang, D., Cai, H., & Huang, H. (2025) · Discover Oncology · doi:10.1007/s12672-025-02358-w · Cited by 13 · see citing works
Nicu, A.-T., Ionel, I. P., Stoica, I., Burlibaşa, L., & Jinga, V. (2024) · Biomedicines · doi:10.3390/biomedicines12051041 · Cited by 11 · see citing works
Li, H., Wu, C., Chang, W., Zhong, L., Gao, W., Zeng, M., Wen, Z., Mai, S., & Chen, Y. (2023) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2810243 · Cited by 10 · see citing works
Samuels, M. E., Karakostas, C., Besta, S., Betrán, A. L., Tsilingiri, K., Turner, C., Nia, R. S., Poudine, N., Goodyear, R. J., Jones, W., et al. (2025) · Molecular Cancer · doi:10.1186/s12943-025-02346-2 · Cited by 8 · see citing works
Su, P., Yang, Y., & Zheng, H. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1779543 · Cited by 8 · see citing works
PSAT1 inhibits MTORC1 activation by preventing RRAG heterodimer formation in lung adenocarcinoma
Liu, Y., Cheng, Z., Zhang, J., Zhang, Y., Zhao, T., Sun, L., Wen, G., Han, T., & Wang, J. (2025) · Autophagy · doi:10.1080/15548627.2025.2535765 · Cited by 6 · see citing works
Sun, Q., Sun, R., He, B., Meng, H., Jin, J., & He, J. (2025) · Drug Development Research · doi:10.1002/ddr.70097 · Cited by 6 · see citing works
A PSAT1 buff of YBX1 transcriptionally sustains HLA-E-mediated evasion of NK immunity
Zhang, Y., Ren, H., Ma, C., Shi, C., Yang, R., Wang, C., Feng, P., Zhang, B., Liu, C., Niu, Z., et al. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2505658122 · Cited by 5 · see citing works
Shi, H., Wang, M., Huang, Y., Liu, Z., Li, L., & Wan, L. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e31705 · Cited by 5 · see citing works
Self-citationVoor, S. F., Cooper, A. J. L., & Pinto, J. T. (2025) · Analytical Biochemistry · doi:10.1016/j.ab.2025.115989 · Cited by 4 · see citing works
Identification and Validation of Serum Biomarkers to Improve Colorectal Cancer Diagnosis
Yoon, M. L., Chun, H., Lee, H., Seo, W., Lee, J. Y., & Yoon, J. H. (2024) · Cancer Medicine · doi:10.1002/cam4.70460 · Cited by 4 · see citing works
PSAT1 inhibits ferroptosis in osteosarcoma cells by activating the Xct/GPX4 signaling axis
Wang, P., Xiao, J., Zeng, J., Yang, F., Lin, M., Tao, L., Liu, H., & Zhan, H. (2025) · Scientific Reports · doi:10.1038/s41598-025-09568-w · Cited by 4 · see citing works
Barnabas, G. D., Bhat, T. A., Goebeler, V., Leclair, P., Azzam, N., Melong, N., Anderson, C., Gom, A., An, S., Ergin, E. K., et al. (2025) · EMBO Molecular Medicine · doi:10.1038/s44321-025-00212-8 · Cited by 4 · see citing works
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Jiang, D., Wang, C., Zhao, Y., & Li, Y. (2026) · Frontiers in Oncology · doi:10.3389/fonc.2026.1676560 · Cited by 3 · see citing works
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Han, X., Liu, J.-N., Sun, N.-X., Zhang, Y.-X., Bai, H.-B., Song, W.-G., Hu, X., Liang, H., Miao, X., He, Y.-M., et al. (2025) · BMC Veterinary Research · doi:10.1186/s12917-025-04736-6 · Cited by 2 · see citing works
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Alatawi, S. M., & AlZamzami, W. (2024) · PLoS ONE · doi:10.1371/journal.pone.0309456 · Cited by 2 · see citing works
Liao, Z., Jia, P., Li, Y., Zheng, Z., & Zhang, J. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1464259 · Cited by 1 · see citing works
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Murali, R., Singaraj, S., Govindh, I., Singh, P., Sundaram, S., Srinivas, S., Gopisetty, G., Chandramoorthy, H. C. K., & Gandhirajan, R. K. (2025) · Next research. · doi:10.1016/j.nexres.2025.100660 · Cited by 1 · see citing works
Huang, X., Yan, J., Peng, S., Zhou, Y., & Chen, S. (2025) · Tissue and Cell · doi:10.1016/j.tice.2025.103091 · Cited by 1 · see citing works
Zheng, Y., Li, L., Bing, L., Yang, Y., Zhang, Y., Lin, Y., Huang, W., & Zhang, R. (2024) · Research Square · doi:10.21203/rs.3.rs-3888711/v1
Self-citationBarnabas, G. D., Bhat, T. A., Goebeler, V., Leclair, P., Azzam, N., Melong, N., Anderson, C., Gom, A., An, S., Ergin, E. K., et al. (2024) · medRxiv · doi:10.1101/2024.07.04.24309923
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Kokošar, J., Turkay, Ç., Avsec, L., Štajdohar, M. R., & Zupan, B. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.05.14.654136
Gao, J., Yang, Y., Chang, X., Wang, X., Zhang, Z., Shi, S., Liu, Y., Su, J., Chen, Z., Sun, R., et al. (2026) · Cancer Cell International · doi:10.1186/s12935-026-04171-z
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Wang, S., Wang, Q., Wang, Y., & Shao, X. (2026) · The Tohoku Journal of Experimental Medicine · doi:10.1620/tjem.2025.j170
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Chen, Q., Hu, H., Peng, Y., Liu, H., Jiang, Y., Feng, Q., & Li, B. (2026) · Biology · doi:10.3390/biology15201811
- Authors
- Feng, M., Cui, H., Tu, W., Li, L., Gao, Y., Chen, L., Li, D., Chen, X., Xu, F., Zhou, C., & Cao, Y.
- Affiliations
- Fudan University Shanghai Cancer Center (CN)
- Corresponding author
- Xu, Fengfeng
- Zhou, Changshuai
- Cao, Yiqun
- Venue
- Frontiers in Genetics
- Publisher
- Frontiers Media SA
- Published
- 2022-08-29
- Volume
- 13
- Pages
- 975381-975381
- ISSN
- 1664-8021 (ISSN-L)
- PMC
- PMC9465327
- OpenAlex
- W4293425990
- Cited by
- 37
- References
- 31
- Citations by year
- 2026: 7 · 2025: 14 · 2024: 8 · 2023: 8
- FWCI
- 3.14
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Genetics (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Ferroptosis and cancer prognosis
- Keywords
- PSAT1, pan-cancer analysis, prognostic factors, immunotherapy response, lung adenocarcinoma, invasive breast cancer, DNA methylation, tumor immune cell infiltration, tumor mutational burden, microsatellite instability, TIDE score, mTORC1 signaling, MYC target genes, JAK/STAT3 signaling, oncogenes
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