The DOI matches its Crossref record; 177 of the 177 references it cites were found in a registry or an index.
Regulation of Adaptive Immunity; The Role of Interleukin-10
Open accessAbstract
Since the discovery of interleukin-10 (IL-10) in the 1980s, a large body of work has led to its recognition as a pleiotropic immunomodulatory cytokine that affects both the innate and adaptive immune systems. IL-10 is produced by a wide range of cell types, but for the purposes of this review we shall focus on IL-10 secreted by CD4(+) T cells. Here we describe the importance of IL-10 as a mediator of suppression used by both FoxP3(+) and FoxP3(-) T regulatory cells. Moreover, we discuss the molecular events leading to the induction of IL-10 secretion in T helper cell subsets, where it acts as a pivotal negative feedback mechanism. Finally we discuss how a greater understanding of this principle has allowed for the design of more efficient, antigen-specific immunotherapy strategies to exploit this natural phenomenon clinically.
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Cites
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Cited by
Tumor-Associated Macrophages: From Mechanisms to Therapy
Noy, R., & Pollard, J. W. (2014) · Immunity · doi:10.1016/j.immuni.2014.06.010 · Cited by 4,089
“TGF-b inhibits cytotoxic T lymphocyte, Th1, and Th2 CD4+ T cells (Oh and Li, 2013), whereas IL-10 inhibits Th1 and Th2 CD4+ T cell helper functions (Ng et al., 2013).”
BackgroundRoles of the immune system in cancer: From tumor initiation to metastatic progression
Gonzalez, H., Hagerling, C., & Werb, Z. (2018) · Genes & Development · doi:10.1101/gad.314617.118 · Cited by 2,111
Britton, G. J., Contijoch, E. J., Mogno, I., Vennaro, O. H., Llewellyn, S. R., Ng, R., Li, Z., Mortha, A., Merad, M., Das, A., et al. (2019) · Immunity · doi:10.1016/j.immuni.2018.12.015 · Cited by 549
Self-citationCarlini, V., Noonan, D. M., Abdalalem, E., Goletti, D., Sansone, C., Calabrone, L., & Albini, A. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1161067 · Cited by 543
Anti-Inflammatory Activity of Natural Products
Azab, A., Nassar, A., & Azab, A. (2016) · Molecules · doi:10.3390/molecules21101321 · Cited by 462
Metadata
- Authors
- Ng, T. H. S., Britton, G. J., Hill, E. V., Verhagen, J., Burton, B. R., & Wraith, D. C.
- Venue
- Frontiers in Immunology
- Publisher
- Frontiers Media SA
- Published
- 2013
- Volume
- 4
- Pages
- 129-129
- ISSN
- 1664-3224 (ISSN-L)
- OpenAlex
- W1998387067
- Cited by
- 354
- References
- 177
- FWCI
- 11.17
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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