The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Bacterial Outer Membrane Vesicles and Vaccine Applications
Open accessAbstract
Vaccines based on outer membrane vesicles (OMV) were developed more than 20 years ago against Neisseria meningitidis serogroup B. These nano-sized structures exhibit remarkable potential for immunomodulation of immune responses and delivery of meningococcal antigens or unrelated antigens incorporated into the vesicle structure. This paper reviews different applications in OMV Research and Development (R&D) and provides examples of OMV developed and evaluated at the Finlay Institute in Cuba. A Good Manufacturing Practice (GMP) process was developed at the Finlay Institute to produce OMV from N. meningitidis serogroup B (dOMVB) using detergent extraction. Subsequently, OMV from N. meningitidis, serogroup A (dOMVA), serogroup W (dOMVW), and serogroup X (dOMVX) were obtained using this process. More recently, the extraction process has also been applied effectively for obtaining OMV on a research scale from Vibrio cholerae (dOMVC), Bordetella pertussis (dOMVBP), Mycobacterium smegmatis (dOMVSM), and BCG (dOMVBCG). The immunogenicity of the OMV has been evaluated for specific antibody induction, and together with functional bactericidal and challenge assays in mice has shown their protective potential. dOMVB has been evaluated with non-neisserial antigens, including with a herpes virus type 2 glycoprotein, ovalbumin, and allergens. In conclusion, OMV are proving to be more versatile than first conceived and remain an important technology for development of vaccine candidates.
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Cited by
Cell Membrane Coating Nanotechnology
Fang, R. H., Kroll, A. V., Gao, W., & Zhang, L. (2018) · Advanced Materials · doi:10.1002/adma.201706759 · Cited by 1,885
Bacterial outer membrane vesicles suppress tumor by interferon-γ-mediated antitumor response
Kim, O. Y., Park, H. T., Dinh, N. T. H., Choi, S. J., Lee, J., Kim, J. H., Lee, S.-W., & Gho, Y. S. (2017) · Nature Communications · doi:10.1038/s41467-017-00729-8 · Cited by 616
Bacterial outer membrane vesicles as a platform for biomedical applications: An update
Li, M., Zhou, H., Yang, C., Wu, Y., Zhou, X., Liu, H., & Wang, Y. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.04.031 · Cited by 370
Veith, P. D., Chen, Y.-Y., Chen, D., O’Brien-Simpson, N. M., Cecil, J. D., Holden, J. A., Lenzo, J. C., & Reynolds, E. C. (2015) · Journal of Proteome Research · doi:10.1021/acs.jproteome.5b00878 · Cited by 41
Metadata
- Authors
- Acevedo, R., Fernández, S., Zayas, C., Acosta, A., Sarmiento, M. E., Ferro, V. A., Rosenqvist, E., Campa, C., Cardoso, D., Garcia, L., & Perez, J. L.
- Venue
- Frontiers in Immunology
- Publisher
- Frontiers Media SA
- Published
- 2014-03-24
- Volume
- 5
- Pages
- 121-121
- ISSN
- 1664-3224 (ISSN-L)
- OpenAlex
- W1992007086
- Cited by
- 254
- References
- 35
- FWCI
- 15.60
- Type
- journal article
- Language
- en
- Open access
- gold
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- Acevedo, R., Fernández, S., Zayas, C., Acosta, A., Sarmiento, M. E., Ferro, V. A., Rosenqvist, E., Campa, C., Cardoso, D., Garcia, L., & Perez, J. L. (2014). Bacterial Outer Membrane Vesicles and Vaccine Applications. Frontiers in Immunology. https://doi.org/10.3389/fimmu.2014.00121
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