The DOI matches its Crossref record; 126 of the 127 references it cites were found in a registry or an index.
Five Layers of Receptor Signaling in γδ T-Cell Differentiation and Activation
Open accessAbstract
The contributions of γδ T-cells to immunity to infection or tumors critically depend on their activation and differentiation into effectors capable of secreting cytokines and killing infected or transformed cells. These processes are molecularly controlled by surface receptors that capture key extracellular cues and convey downstream intracellular signals that regulate γδ T-cell physiology. The understanding of how environmental signals are integrated by γδ T-cells is critical for their manipulation in clinical settings. Here, we discuss how different classes of surface receptors impact on human and murine γδ T-cell differentiation, activation, and expansion. In particular, we review the role of five receptor types: the T-cell receptor (TCR), costimulatory receptors, cytokine receptors, NK receptors, and inhibitory receptors. Some of the key players are the costimulatory receptors CD27 and CD28, which differentially impact on pro-inflammatory subsets of γδ T-cells; the cytokine receptors IL-2R, IL-7R, and IL-15R, which drive functional differentiation and expansion of γδ T-cells; the NK receptor NKG2D and its contribution to γδ T-cell cytotoxicity; and the inhibitory receptors PD-1 and BTLA that control γδ T-cell homeostasis. We discuss these and other receptors in the context of a five-step model of receptor signaling in γδ T-cell differentiation and activation, and discuss its implications for the manipulation of γδ T-cells in immunotherapy.
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“IL-12 and IL-18 promote IFN-γ production, while IL-1β and IL-23 drive them towards IL-17-producing cells (14).”
From Comparing Mouse and Human Tissue-Resident γδ T Cells (2022) · cites this paper as [14]
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Cites
1 retracted
IL-21 Regulates the Differentiation of a Human γδ T Cell Subset Equipped with B Cell Helper Activity
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Research works printed but not linked: 1
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Early Immune Pathology and Persistent Dysregulation Characterise Severe COVID-19
Bergamaschi, L., Mescia, F., Turner, L., Hanson, A., Kotagiri, P., Dunmore, B. J., Ruffieux, H., Sa, A. D., Huhn, O., Morgan, M. D., et al. (2020) · Immunity · doi:10.1016/j.immuni.2021.05.010 · Cited by 334
“Similar, though less well defined, bystander phenomena occur in CD4, MAIT, and gd T cell responses (Holzapfel et al., 2014; Ribeiro et al., 2015; Ussher et al., 2018).”
Shandilya, S., Kumar, S., Jha, N. K., Kesari, K. K., & Ruokolainen, J. (2021) · Journal of Advanced Research · doi:10.1016/j.jare.2021.09.005 · Cited by 310
NF-kappaB: Two Sides of the Same Coin
Pires, B. R. B., Silva, R. C. M. C., Ferreira, G. M., & Abdelhay, E. S. F. W. (2018) · Genes · doi:10.3390/genes9010024 · Cited by 243
Almeida, A. R. M., Correia, D. V., Fernandes‐Platzgummer, A., da Silva, C. L., da Silva, M. G., Anjos, D. R., & Silva‐Santos, B. (2016) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-16-0597 · Cited by 238
“In contrast, key inhibitory and exhaustion-associated molecules such as PD-1, CTLA-4, or CD94 (24) were expressed either at very low levels or not expressed at all (Fig.”
BackgroundSelf-citationLawand, M., Déchanet‐Merville, J., & Dieu‐Nosjean, M. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00761 · Cited by 240
Metadata
- Authors
- Ribeiro, S. T., Ribot, J. C., & Silva-Santos, B.
- Affiliations
- University of Lisbon (PT)
- ORCID
- Ribot, Julie C.
- Venue
- Frontiers in Immunology
- Publisher
- Frontiers Media SA
- Published
- 2015-01-26
- Volume
- 6
- Pages
- 15-15
- ISSN
- 1664-3224 (ISSN-L)
- PMC
- PMC4306313
- OpenAlex
- W2027271725
- Semantic Scholar
- d2d3632814aa56e04fe85192b8fcd093a630672b
- Cited by
- 116
- References
- 127
- Citations by year
- 2026: 5 · 2025: 9 · 2024: 7 · 2023: 4 · 2022: 15 · 2021: 21 · 2020: 15 · 2019: 13 · 2018: 13 · 2017: 8 · 2016: 4 · 2015: 2
- FWCI
- 0.85
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Immunology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion, other-oa)
- Funders
- Fundação para a Ciência e a Tecnologia (SFRH/BD/84123/2012)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immune Cell Function and Interaction
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Keywords
- γδ T cells, receptor signaling, T cell activation, T cell differentiation, costimulatory receptors, CD27, CD28, cytokine receptors, interleukin-2 receptor, IL-7 receptor, IL-15 receptor, NK cell receptors, NKG2D, cytotoxicity, inhibitory receptors, PD-1, BTLA, T cell homeostasis, immunotherapy
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