The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Splenic Macrophage Subsets and Their Function during Blood-Borne Infections
Open accessAbstract
The spleen is one of the major immunological sites for maintaining blood homeostasis. Previous studies showed that heterogeneous splenic macrophage populations contribute in complimentary ways to control blood-borne infections and induce effective immune responses. Marginal metallophilic macrophages (MMMΦs) and marginal zone macrophages (MZMΦs) are cells with great ability to internalize blood-borne pathogens such as virus or bacteria. Their localization adjacent to T- and B-cell-rich splenic areas favors the rapid contact between these macrophages and cells from adaptive immunity. Indeed, MMMΦs and MZMΦs are considered important bridges between innate and adaptive immunity. Although red pulp macrophages (RpMΦs) are mainly considered scavengers for senescent erythrocytes, several data indicate a role for RpMΦs in control of infections such as blood-stage malaria as well as in the induction of innate and adaptive immunity. Here, we review current data on how different macrophage subsets recognize and help eliminate blood-borne pathogens, and, in turn, how the inflammatory microenvironment in different phases of infection (acute, chronic, and after pathogen clearance) influences macrophage function and survival.
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Cites
A Toll-like receptor recognizes bacterial DNA
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“As stated previously, RpMΦs form a vast network inside the Rp, and although there is no consensus about the origin of RpMΦs, recent data indicate that these MΦs are maintained by local proliferation during physiological conditions (31).”
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Role for Spi-C in the development of red pulp macrophages and splenic iron homeostasis
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“Evidencing RpMΦs crucial role in neutralizing toxic effects of hemoglobin, these MΦs have high levels of intracellular heme due to RBC phagocytosis (2) and of free hemoglobin through the scavenger receptor CD163 (49).”
Heme-mediated SPI-C induction promotes monocyte differentiation into iron-recycling macrophages
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“Of note, development of RpMΦs relies on the expression of the transcription factor Spi-C, which is induced by free heme from RBC degradation (32).”
BackgroundCD47 functions as a molecular switch for erythrocyte phagocytosis
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Deciphering spatial domains from spatial multi-omics with SpatialGlue
Long, Y., Ang, K. S., Sethi, R., Liao, S., Heng, Y., van Olst, L., Ye, S., Zhong, C., Xu, H., Zhang, D., et al. (2024) · Nature Methods · doi:10.1038/s41592-024-02316-4 · Cited by 223
A new genetic strategy for targeting microglia in development and disease
McKinsey, G. L., Lizama, C. O., Keown-Lang, A. E., Niu, A., Santander, N., Larpthaveesarp, A., Chee, E., Gonzalez, F. F., & Arnold, T. D. (2020) · eLife · doi:10.7554/elife.54590 · Cited by 176
Wang, H., Li, S., Cui, Z., Qin, T., Shi, H., Ma, J., Li, L., Yu, G., Jiang, T., & Li, C. (2021) · Malaria Journal · doi:10.1186/s12936-021-03786-z · Cited by 36
Metadata
- Authors
- Borges da Silva, H., Fonseca, R., Pereira, R. M., Cassado, A. D. A., Álvarez, J. M., & D’Império Lima, M. R.
- Venue
- Frontiers in Immunology
- Publisher
- Frontiers Media SA
- Published
- 2015-09-22
- Volume
- 6
- Pages
- 480-480
- ISSN
- 1664-3224 (ISSN-L)
- OpenAlex
- W1444346221
- Cited by
- 202
- References
- 8
- FWCI
- 5.77
- Type
- journal article
- Language
- en
- Open access
- gold
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- Borges da Silva, H., Fonseca, R., Pereira, R. M., Cassado, A. D. A., Álvarez, J. M., & D’Império Lima, M. R. (2015). Splenic Macrophage Subsets and Their Function during Blood-Borne Infections. Frontiers in Immunology. https://doi.org/10.3389/fimmu.2015.00480
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