The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Murine Butyrophilin-Like 1 and Btnl6 Form Heteromeric Complexes in Small Intestinal Epithelial Cells and Promote Proliferation of Local T Lymphocytes
Open accessAbstract
To date, few molecular conduits mediating the cross-talk between intestinal epithelial cells and intraepithelial lymphocytes (IELs) have been described. We recently showed that butyrophilin-like (Btnl) 1 can attenuate the epithelial response to activated IELs, resulting in reduced production of proinflammatory mediators, such as IL-6 and CXCL1. We here report that like Btnl1, murine Btnl6 expression is primarily confined to the intestinal epithelium. Although Btnl1 can exist in a cell surface-expressed homomeric form, we found that it additionally forms heteromeric complexes with Btnl6, and that the engagement of Btnl1 is a prerequisite for surface expression of Btnl6 on intestinal epithelial cells. In an IEL-epithelial cell coculture system, enforced epithelial cell expression of Btnl1 significantly enhanced the proliferation of IELs in the absence of exogenous activation. The effect on proliferation was dependent on the presence of IL-2 or IL-15 and restricted to IELs upregulating CD25. In the γδ T-cell subset, the Btnl1-Btnl6 complex, but not Btnl1, specifically elevated the proliferation of IELs bearing the Vγ7Vδ4 receptor. Thus, our results show that murine epithelial cell-specific Btnl proteins can form intrafamily heterocomplexes and suggest that the interaction between Btnl proteins and IELs regulates the expansion of IELs in the intestinal mucosa.
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Sarcoidosis is associated with a truncating splice site mutation in BTNL2
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Butyrophilin 3A1 binds phosphorylated antigens and stimulates human γδ T cells
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Interferon-γ acts directly on CD8+ T cells to increase their abundance during virus infection
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BTNL2, a Butyrophilin-Like Molecule That Functions to Inhibit T Cell Activation
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Metadata
- Authors
- Lebrero-Fernández, C., Bergström, J. H., Pelaseyed, T., & Bas-Forsberg, A.
- Venue
- Frontiers in Immunology
- Publisher
- Frontiers Media SA
- Published
- 2016-01-19
- Volume
- 7
- Pages
- 1-1
- ISSN
- 1664-3224 (ISSN-L)
- OpenAlex
- W2245890504
- Cited by
- 371
- References
- 36
- FWCI
- 28.94
- Type
- journal article
- Language
- en
- Open access
- gold
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- CoChat. (2026). Citation check: Murine Butyrophilin-Like 1 and Btnl6 Form Heteromeric Complexes in Small Intestinal Epithelial Cells and Promote Proliferation of Local T Lymphocytes. https://app.cochat.ai/papers/10.3389/fimmu.2016.00001
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- Lebrero-Fernández, C., Bergström, J. H., Pelaseyed, T., & Bas-Forsberg, A. (2016). Murine Butyrophilin-Like 1 and Btnl6 Form Heteromeric Complexes in Small Intestinal Epithelial Cells and Promote Proliferation of Local T Lymphocytes. Frontiers in Immunology. https://doi.org/10.3389/fimmu.2016.00001
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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