The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
BTNL2, a Butyrophilin-Like Molecule That Functions to Inhibit T Cell Activation
Open accessAbstract
B7 family members regulate T cell activation and tolerance. Although butyrophilin proteins share sequence homology with the B7 molecules, it is unclear whether they have any function in immune responses. In the present study, we characterize an MHC class II gene-linked butyrophilin family member, butyrophilin-like 2 (BTNL2), the mutation of which has been recently associated with the inflammatory autoimmune diseases sarcoidosis and myositis. Mouse BTNL2 is a type I transmembrane protein with two pairs of Ig-like domains separated by a heptad peptide sequence. BTNL2 mRNA is highly expressed in lymphoid tissues as well as in intestine. To characterize the function of BTNL2, we produced a BTNL2-Ig fusion protein. It recognized a putative receptor whose expression on B and T cells was significantly enhanced after activation. BTNL2-Ig inhibited T cell proliferation and TCR activation of NFAT, NF-κB, and AP-1 signaling pathways. BTNL2 is thus the first member of the butyrophilin family that regulates T cell activation, which has implications in immune diseases and immunotherapy.
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Janeway, C. A., & Medzhitov, R. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.083001.084359 · Cited by 8,394
Nishimura, H., Nose, M., Hiai, H., Minato, N., & Honjo, T. (1999) · Immunity · doi:10.1016/s1074-7613(00)80089-8 · Cited by 2,749
ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28
Hutloff, A., Dittrich, A. M., Beier, K. C., Eljaschewitsch, B., Kraft, R., Anagnostopoulos, I., & Kroczek, R. A. (1999) · Nature · doi:10.1038/16717 · Cited by 1,482
The B7 family member B7-H3 preferentially down-regulates T helper type 1–mediated immune responses
Suh, W.-K., Gajewska, B. U., Okada, H., Gronski, M. A., Bertram, E. M., Dawicki, W., Duncan, G. S., Bukczynski, J., Plyte, S., Elia, A., et al. (2003) · Nature Immunology · doi:10.1038/ni967 · Cited by 576
Murine B7-H3 is a negative regulator of T cells
Prasad, D. V. R., Nguyen, T., Li, Z., Yang, Y., Duong, J., Wang, Y., & Dong, C. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.4.2500 · Cited by 368 · cited 3×
“Human B7-H3 was first found to be a positive costimulator (15); recent studies by others suggested that mouse B7-H3 may serve as a negative regulator in T cell activation (16, 17).”
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Valeyre, D., Prasse, A., Nunes, H., Uzunhan, Y., Brillet, P.-Y., & Müller-Quernheim, J. (2014) · The Lancet · doi:10.1016/s0140-6736(13)60680-7 · Cited by 1,087
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Nielsen, M. M., Witherden, D. A., & Havran, W. L. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2017.101 · Cited by 479
Lebrero-Fernández, C., Bergström, J. H., Pelaseyed, T., & Bas-Forsberg, A. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00001 · Cited by 371
Yin–Yang of costimulation: crucial controls of immune tolerance and function
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Metadata
- Authors
- Nguyen, T., Liu, X. K., Zhang, Y., & Dong, C.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-06
- Volume
- 176
- Issue
- 12
- Pages
- 7354-7360
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1506942171
- Cited by
- 195
- References
- 5
- FWCI
- 3.39
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Nguyen, T., Liu, X. K., Zhang, Y., & Dong, C. (2006). BTNL2, a Butyrophilin-Like Molecule That Functions to Inhibit T Cell Activation. The Journal of Immunology. https://doi.org/10.4049/jimmunol.176.12.7354
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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